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  4. Recombinant Netrin unc-6 (unc-6), partial

Recombinant Netrin unc-6 (unc-6), partial

  • 中文名称：
    秀丽隐杆线虫unc-6重组蛋白
  • 货号：
    CSB-YP341568CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    秀丽隐杆线虫unc-6重组蛋白
  • 货号：
    CSB-EP341568CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    秀丽隐杆线虫unc-6重组蛋白
  • 货号：
    CSB-EP341568CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    秀丽隐杆线虫unc-6重组蛋白
  • 货号：
    CSB-BP341568CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    秀丽隐杆线虫unc-6重组蛋白
  • 货号：
    CSB-MP341568CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    unc-6
  • Uniprot No.：
    P34710
  • 别名：
    unc-6; F41C6.1Netrin unc-6; Uncoordinated protein 6
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. In particular, it is required for the guidance of axons from neurons, including SubL neurons and AIY interneurons, into the nerve ring. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in dendritic morphogenesis; may act by association with unc-40 at the tips of growing dendrites for interaction with unc-5 on the apposing branch to induce mutual repulsion. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation of synapses between the AVA interneurons and the PHB sensory neurons.
  • 基因功能参考文献：
    1. rom these studies we conclude that FMO-1, FMO-4, FMO-5, and EHBP-1 represent new players downstream of UNC-6/Netrin receptors and Rac GTPases that inhibit growth cone filopodial protrusion in repulsive axon guidance PMID: 28859089
    2. LON-2/glypican acts as a modulator of UNC-40/DCC-mediated guidance to fine-tune axonal responses to UNC-6/netrin signals during migration. PMID: 26148345
    3. Ire-1/xbp-1 pathway of the unfolded protein response is crucial for establishing positional information of UNC-6/Netrin. PMID: 25469499
    4. UNC-116/KHC acts in part with the cell and axon migration molecules UNC-6/Netrin and UNC-40/DCC in this process, but in parallel to SAX-3/Robo. PMID: 23475988
    5. This study demonistrated that Netrin (UNC-6) mediates dendritic self-avoidance PMID: 22426253
    6. We found that the guidance cue UNC-6 (Netrin) is required for both axon and dendrite development. PMID: 21186357
    7. Mutants with impaired growth cone functions, such as unc-6, often exhibit abnormal terminations and inappropriate trajectories at the distal ends of the M2 axons. PMID: 12885562
    8. loss-of-function mutations in clr-1 enhance netrin-dependent axon attraction PMID: 15232111
    9. Data show that UNC-6 and UNC-40 function during axon formation to initiate, maintain and orient asymmetric neuronal growth. PMID: 16520734
    10. Genetic analyses indicate that MIG-10/RIAM/lamellipodin, a cytoplasmic adaptor protein, functions downstream of the attractive guidance cue UNC-6/netrin to direct the ventral migration of the AVM and PVM axons in C. elegans. PMID: 16563765
    11. UNC-6 expressed by the VPC and the VNC cooperatively regulates the complex HSN axon guidance. PMID: 17320069
    12. study show that connectivity between two interneurons, AIY and RIA, in Caenorhabditis elegans is orchestrated by a pair of glial cells that express UNC-6 (netrin) PMID: 17916735
    13. Together, these results characterize an invasive membrane domain in vivo, and reveal a role for UNC-6 (netrin) in polarizing this domain towards its basement membrane target. PMID: 19098902

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane. Note=Epidermal basal lamina.
  • 数据库链接：

    KEGG: cel:CELE_F41C6.1

    STRING: 6239.F41C6.1.2

    UniGene: Cel.6945

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