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  4. Recombinant Mouse Zinc finger protein ZFPM1 (Zfpm1), partial

Recombinant Mouse Zinc finger protein ZFPM1 (Zfpm1), partial

  • 中文名称：
    小鼠Zfpm1重组蛋白
  • 货号：
    CSB-YP026463MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Zfpm1重组蛋白
  • 货号：
    CSB-EP026463MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Zfpm1重组蛋白
  • 货号：
    CSB-EP026463MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Zfpm1重组蛋白
  • 货号：
    CSB-BP026463MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Zfpm1重组蛋白
  • 货号：
    CSB-MP026463MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Zfpm1
  • Uniprot No.：
    O35615
  • 别名：
    Zfpm1; Fog; Fog1Zinc finger protein ZFPM1; Friend of GATA protein 1; FOG-1; Friend of GATA 1; Zinc finger protein multitype 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
  • 基因功能参考文献：
    1. FOG1 is a member of the PR domain containing, zinc finger protein family of transcriptional regulators. PMID: 25162672
    2. the role of FOG-1 in B lymphocytes PMID: 24747299
    3. FOG-1 is required for the formation of all committed Mk- and E-lineage progenitors. It mediates transcriptional megakaryocyte/erythrocyte programming of HSCs as well as their subsequent Mk/E-lineage commitment. PMID: 22068055
    4. Disruption of the GATA1/FOG1/NuRD transcriptional system results in a complex, pleiotropic platelet defect beyond gray platelet syndrome-like macrothrombocytopenia. PMID: 21989988
    5. These results implicate FOG1 and 2 and CTBPs as partners of GATA proteins in the control of adipocyte proliferation and differentiation. PMID: 20705609
    6. role of the hematopoietic transcription factor GATA-1, its cofactor FOG-1, and the associated chromatin remodeling complex NuRD in the developmental silencing of HBG1 and HBG2 gene expression PMID: 20439494
    7. The continuous presence of GATA1, FOG1, and NuRD is required to maintain lineage fidelity throughout megakaryocyte-erythroid ontogeny. PMID: 20065294
    8. Data demonstrate that sumoylation of GATA-1 K137 promotes transcriptional activation only at target genes requiring the coregulator Friend of GATA-1 (FOG-1). PMID: 20064464
    9. Gene expression analysis in primary mutant erythroid cells and megakaryocytes revealed an essential function for NuRD during both the repression and activation of select Gata-1/Fog1 target genes. PMID: 19927129
    10. Homozygous Fog1(R3K5A) mice were found to have splenomegaly, extramedullary erythropoiesis, granulocytosis and thrombocytopaenia secondary to a block in megakaryocyte maturation. PMID: 20010697
    11. Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. PMID: 11940669
    12. may modulate the fate of a bipotential erythroid/megakaryocytic precursor cell. PMID: 12024038
    13. requires an interaction with either GATA-1 or -2 as part of its essential role in early megakaryopoiesis PMID: 12077323
    14. FOG-2, in addition to GATA-4, has a role in early gonadal development and sexual differentiation, and FOG-1 at later fetal stages, while GATA-1 executes its action postnatally PMID: 12213678
    15. plays a role in the control of megakaryocyte-specific gene expression with gata-1: Ets transcription factors also have a role PMID: 12356738
    16. nonredundant requirement for FOG-1 in the outlet tract and atrioventricular valves of the heart that depend on expression in endothelial-derived tissue and presumably reflect cooperation with the GATA-4/5/6 subfamily PMID: 14614148
    17. Transgene expression comparable to the endogenous GATA-1 level resulted in much lower frequency of rescue, indicating that the GATA-1-FOG-1 association is critical for normal embryonic hematopoiesis. PMID: 14656885
    18. the alpha-helix of FOG-ZF3 recognizes a C-terminal portion of the TACC3 coiled-coil PMID: 15234987
    19. Status of differentiation depends on FOG-1 protein. PMID: 15569153
    20. GATA-1 and its cofactor FOG-1 are required for the physical interaction between the beta-globin locus control region (LCR) and the beta-major globin promoter. PMID: 15694345
    21. functional interaction between GATA-4 and a member of the FOG family, presumably FOG-1, is required for proper epithelial-mesenchymal signaling in the developing stomach PMID: 16127717
    22. identification of genes repressed by GATA-1 independent of FOG-1 defines a novel mode of GATA-1-mediated transcriptional regulation PMID: 17339418
    23. during definitive erythropoiesis, gamma-globin gene expression is silenced, in part, by binding a protein complex containing GATA-1, FOG-1, and Mi2 at the -566/-567 GATA sites of the proximal gamma-globin promoters PMID: 18347053
    24. Fog1 mRNA displayed a proximal-distal pattern that parallels that of Gata4, and FOG1 protein was co-expressed with GATA4 in intestinal epithelial cells, implicating FOG1 as the likely mediator of GATA4 function in the small intestine PMID: 18692040
    25. two novel mechanisms for the regulation of GATA1 interaction with FOG1-dependent protein complexes through the production of two translational isoforms with differential interaction profiles and independent nuclear localization controls. PMID: 19654328

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    FOG (Friend of GATA) family
  • 组织特异性：
    Mainly expressed in hematopoietic tissues. Expressed in the spleen, a primary site of hematopoiesis in the adult mouse, as well as in the liver and testis, but not in the heart, brain, lung, kidney, or skeletal muscle. Among hematopoietic cell lines, it i
  • 数据库链接：

    KEGG: mmu:22761

    STRING: 10090.ENSMUSP00000058037

    UniGene: Mm.3105

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