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  4. Recombinant Mouse Zinc finger protein RFP (Trim27), partial

Recombinant Mouse Zinc finger protein RFP (Trim27), partial

  • 中文名称：
    小鼠Trim27重组蛋白
  • 货号：
    CSB-YP717253MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Trim27重组蛋白
  • 货号：
    CSB-EP717253MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Trim27重组蛋白
  • 货号：
    CSB-EP717253MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Trim27重组蛋白
  • 货号：
    CSB-BP717253MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Trim27重组蛋白
  • 货号：
    CSB-MP717253MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trim27
  • Uniprot No.：
    Q62158
  • 别名：
    Trim27; Rfp; Zinc finger protein RFP; EC 2.3.2.27; RING-type E3 ubiquitin transferase TRIM27; Ret finger protein; Tripartite motif-containing protein 27
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 表达区域：
    -
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.
  • 基因功能参考文献：
    1. Deficiency of TRIM27 significantly impairs dextran sulfate sodium (DSS)-induced STAT3 activation, inflammatory cytokine expression and colitis as well as azoxymethane (AOM)/DSS-induced colitis-associated cancer in mice PMID: 30143645
    2. Trim27 connecting Slx2 may regulate meiotic processes in multiple ways by influencing XY body formation and germ cell proliferation during spermatogenesis. PMID: 27612028
    3. our study suggests that nicotine may induce murine spermatozoal apoptosis via the TNF apoptotic pathway through up-regulation of deubiquitinated RIP1 by Trim27 promoter hypomethylation. PMID: 26607717
    4. TRIM27 inhibits VSV infection-induced type I IFN production by promoting TBK1 degradation. PMID: 26358190
    5. Ret finger protein works as a novel E3 ligase in the Pax7-mediated degradation of MyoD in response to skeletal muscle atrophy. PMID: 25025573
    6. Data showed that Trim27 deficiency decreases apoptosis and protects dopaminergic neurons in MPTP poisoning, suggesting that Trim27 may be an effective potential target during the treatment of Parkinson's disease PMID: 25223908
    7. The neoplasm leading cell specific expression of integrin beta1 was posttranscriptionally regulated by the TRIM27/MRTF-B complex in response to the loss of intercellular adhesion. PMID: 24794433
    8. The ubiquitination-deubiquitination cascade mediated by the TRIM27-USP7 complex plays an important role in TNF-alpha-induced apoptosis. PMID: 24144979
    9. study found that TRIM27 negatively regulates FcepsilonRI activation of KCa3.1 and downstream signaling by ubiquitinating and inhibiting PI3KC2beta; findings identify TRIM27 as an important negative regulator of mast cells in vivo PMID: 22645315
    10. Trim27(-/-) mice (n = 14) were resistant to chemically induced skin cancer development (eight [57.2%] of 14 mice were tumor free) compared with Trim27(+/+) wild-type littermates (n = 13) (one [7.7%] of 13 mice was tumor free). PMID: 22556269
    11. Epc1-induced enhancements of SRF-dependent multinucleation, transactivation of the skeletal alpha-actin promoter, binding of SRF to the serum response element, and muscle-specific gene induction were blocked by RFP. PMID: 21637294
    12. These findings provide a unique mechanism for regulating class II PI3Ks, and identify TRIM27 as a previously undescribed negative regulator of CD4 T cells. PMID: 22128329
    13. results suggest that bHLH transcription factors are regulated by a previously undescribed interaction with RFP, which functions to recruit HDAC and/or Polycomb proteins and thus repress target genes of bHLH proteins PMID: 16007160

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Nucleus, PML body. Endosome.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Expressed strongly in testis. Low levels were detected in spleen, thymus, cerebrum and cerebellum.
  • 数据库链接：

    KEGG: mmu:19720

    STRING: 10090.ENSMUSP00000021761

    UniGene: Mm.314056

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