Recombinant Mouse Zinc finger protein GLI1 (Gli1), partial

1. data suggest a mechanism by which the stem cell niche is adjusted to meet the needs of the intestine via adaptive changes in the number of mesenchymal GLI1-expressing cells PMID: 29875413
2. these data demonstrate the preclinical efficacy of targeting the downstream HDAC1/2-Gli1 acetylation in the treatment of SHH Medulloblastoma. PMID: 28276480
3. Zinc finger protein GLI1 (Gli1) marks mesenchymal progenitors responsible for both normal bone formation and fracture repair. PMID: 29230039
4. FLT3-mutated in contrast to FLT3 wildtype cells or normal human hematopoietic progenitor cells are exquisitely sensitive to combined inhibition by FLT3, PI3K and GLI1/2 overcoming some of the limitations of current FLT3 directed therapy in AML. PMID: 28418873
5. Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma PMID: 28235772
6. Gli1-expressing bone marrow cells are responsible for primary myelofibrosis in a transgenic mouse model. PMID: 28690072
7. Results indicate that GLI1 is important for maintaining the invasive and mesenchymal-like properties of melanoma cells independent of MITF. PMID: 28635133
8. USP21 recruits and stabilises Gli1 at the centrosome. PMID: 27621083
9. High Gli1 expression is associated with leukemia. PMID: 27443289
10. Sufu is upregulated in active Shh responding tissues and accompanies Gli activators translocating into and Gli repressors out of the nucleus. PMID: 27849569
11. NANOG binds to GLI1 and GLI3 proteins and represses Hedgehog-mediated transcription. PMID: 26797124
12. characterization of the contribution to remyelination of a subset of adult neural stem cells, identified by their expression of Gli1, a transcriptional effector of the sonic hedgehog pathway PMID: 26416758
13. the three GLI factors(GLI1, GLI2, and GLI3) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism PMID: 26010061
14. Gli1, a known Ptch activator, preferentially bound the mutant Ptch locus in rhabdomyosarcoma. PMID: 25823816
15. show that combined targeting of GLI and PI3K/AKT/mTOR signaling can have a synergistic therapeutic effect in cells from a subgroup of chronic lymphocytic leukemia patients PMID: 25639866
16. These findings implicate perivascular Gli1(+) mesenchymal stem cells-like cells as a major cellular origin of organ fibrosis. PMID: 25465115
17. Cortical activation of Gli1 protects mice from induction of hepatic encephalopathy. TGFbeta1 suppresses Gli1 in neurons via SMAD3 and promotes the neurologic decline. PMID: 25046848
18. Ptc1-Gli1 signaling deregulation resulting in abnormal loss of glial precursor cells may contribute to a cognition decline in Alzheimer's disease brains. PMID: 25027328
19. Gli1+ cells within the suture mesenchyme are an indispensable mesenchymal stem cell population supporting craniofacial bone turnover and injury healing. PMID: 25799059
20. Study shows that the SHH-Gli axis drives proliferation in response to kainic acid-induced neurodegeneration PMID: 24895267
21. validate our model by successfully predicting expression changes of Gli1 and Ptch1 in mutants at different developmental stages and in different tissues PMID: 25458012
22. Data indicate a specific genetic requirement for Gli proteins in Hedgehog (Hh)-induced embryonal rhabdhomyosarcoma (eRMS) formation. PMID: 24276242
23. GLI1 modulates the inflammatory response during pancreatic tissue remodeling. PMID: 25104358
24. a new mechanism of Gli transcription factor activation and implicate ARHGAP36 dysregulation in the onset and/or progression of GLI-dependent cancers. PMID: 25024229
25. A Gli-dependent cis-regulatory module (CRM), regulation of Grem1 in the mouse limb bud, is reported. PMID: 24700818
26. These data unveil a p53/PCAF/Gli1 circuitry centered on PCAF that limits Gli1-enhanced mitogenic and prosurvival response. PMID: 24013724
27. Findings uncover a novel epigenetic link whereby menin directly represses Gli1 expression, independent of the canonical Hedgehog signaling pathway. PMID: 23928057
28. Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway. PMID: 24072710
29. SULF2 regulates tissue regeneration in part via the activation of a novel WNT-GLI1-CYCLIN D1 pathway. PMID: 23740243
30. these results define a novel role for GLI1 in carcinogenesis acting as a downstream effector of oncogenic KRAS in the tumor microenvironment. PMID: 23482563
31. Gli3 is required in Emx1+ progenitors for the development of the corpus callosum PMID: 23396189
32. aPKC-iota/lambda functions downstream of smoothened to phosphorylate and activate GLI1, resulting in maximal DNA binding and transcriptional activation PMID: 23446420
33. upon Hedgehog input, Gli1 functions collectively with Gli2 and Gli3 in osteogenesis. PMID: 22493482
34. Data demonstrate that the timing of gene expression along with the genetic lineage (Shh or Gli1) within the neural progenitors segregate mDA neurons into distinct spatial domains. PMID: 21713771
35. PACAP prevented the direct activation of the Sonic hedgehog target gene Gli-1. PMID: 21674568
36. In fetal testes prior to Leydig cell differentiation, expression of Gli1 and Gli2 is abolished by Hedgehog inhibitor GANT61. At later stages, GANT61 inhibits Gli1 expression but has no effects on Gli2 expression and fetal Leydig cell appearance. PMID: 21209421
37. Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures. PMID: 21143927
38. Data show that Gli1 is non-redundant in the regulation of T-cell development in the thymus, at multiple developmental stages. PMID: 20935514
39. SNF5 is a key mediator of Hedgehog signaling and that aberrant activation of GLI1 is a previously undescribed targetable mechanism contributing to the growth of malignant rhabdoid tumor cells. PMID: 21076395
40. Gli1 regulates normal and stress hematopoiesis PMID: 20107231
41. Results show that Gli1 and Gli2 are acetylated proteins and that their HDAC-mediated deacetylation promotes transcriptional activation and sustains a positive autoregulatory loop through Hedgehog-induced upregulation of HDAC1. PMID: 20081843
42. regulation of transcriptional activity in nucleus by Dyrk1 PMID: 12138125
43. in mammals, Gli1 is not required for Shh signaling and that Gli2 mediates inappropriate activation of the pathway due to loss of the negative regulator Ptc. PMID: 12361967
44. GLI-1 has a role in mediating bcl-2 transcriptional regulation by the sonic hedgehog signaling pathway PMID: 14555646
45. Shh, functioning via Gli1/2, can specify mesodermal cells into the cardiac muscle lineage PMID: 15793308
46. Gli1 plays a central role in medulloblastoma formation in Ptc1+/- mice and that Gli2 may also contribute to oncogenesis. PMID: 15806168
47. Gli1 is not required to induce Pdgfra expression during embryonic bone development. PMID: 15811134
48. Results demonstrate that SHH-SMO signaling controls renal morphogenesis via transcriptional control of Gli1 and 2, renal patterning and cell cycle regulator genes in a manner that is opposed by GLI3. PMID: 16396903
49. Here we show that Gli is rapidly destroyed by the proteasome and that mouse basal cell carcinoma induction correlates with Gli protein accumulation,We identify two independent destruction signals in Gli1, D(N) and D(C) PMID: 16421275
50. investigation of GLI protein processing and binding of GLI activators and repressor to sonic hedgehog short digits(SHH) target genes provide insight into the molecular mechanisms by which SHH and its GLI family of effectors control renal embryogenesis PMID: 16855389

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KEGG: mmu:14632

STRING: 10090.ENSMUSP00000026474

UniGene: Mm.391450