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  4. Recombinant Mouse Zinc finger protein 423 (Znf423), partial

Recombinant Mouse Zinc finger protein 423 (Znf423), partial

  • 中文名称：
    小鼠Znf423重组蛋白
  • 货号：
    CSB-YP026738MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Znf423重组蛋白
  • 货号：
    CSB-EP026738MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Znf423重组蛋白
  • 货号：
    CSB-EP026738MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Znf423重组蛋白
  • 货号：
    CSB-BP026738MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Znf423重组蛋白
  • 货号：
    CSB-MP026738MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Znf423
  • Uniprot No.：
    Q80TS5
  • 别名：
    Znf423; Ebfaz; Kiaa0760; Nur12; Oaz; Zfp423; Zinc finger protein 423; Early B-cell factor-associated zinc finger protein; Olf1/EBF-associated zinc finger protein; Smad- and Olf-interacting zinc finger protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
  • 基因功能参考文献：
    1. In vivo, vitamin A supplementation prevents obesity, downregulates Gadd45a expression, and reduces GADD45A binding and DNA demethylation in the Zfp423 promoter. PMID: 28992291
    2. ZFP423 to be expressed in the developing cortex and promote RA-dependent neuronal differentiation. PMID: 29305158
    3. Zfp423/ZNF423 has a role in regulating cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors PMID: 28893945
    4. These data identify Zfp423 as a molecular brake on adipocyte thermogenesis. PMID: 27238639
    5. loss of Zfp423 alters expression of several genes encoding key cilium components, including increased expression of Tulp3. Tulp3 is a direct binding target of Zfp423 and reducing the overexpression of Tulp3 in Zfp423-deficient cells suppresses Smoothened translocation defects. PMID: 27727273
    6. Data show that the expression of miR-195a is regulated during adipocyte differentiation and identified Zfp423 as its novel target. PMID: 25903991
    7. the antiadipogenic function of Zfp521 is mostly exerted through repression of Zfp423 and the downstream target PPAR-gamma gene. PMID: 24891617
    8. Zfp423 binds autoregulatory sites in a developmental cell culture model. PMID: 23762491
    9. Maternal obesity enhanced Zfp423 expression and adipogenic differentiation during fetal development, at least partially through reducing DNA methylation in the Zfp423 promoter. PMID: 23884886
    10. Constitutive expression of a C-terminal mutant OAZ that selectively disrupts OAZ-O/E interaction while retaining other activities, exhibits apparently normal OSN differentiation. PMID: 23035080
    11. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. PMID: 22326224
    12. Zfp423(-/-) hemisphere malformations are shaped by both genetic and non-genetic factors to produce distinct phenotypes. PMID: 21729880
    13. ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. PMID: 20547764
    14. Zfp423 as a transcriptional regulator of preadipocyte determination PMID: 20200519
    15. Ebfaz can substitute for the upregulated expression of Evi3 in B-cell disease and has a role in hematopoietic cancer PMID: 15048087
    16. Homozygous Zfp423 null mice are runted and ataxic, the cerebellum is underdeveloped, and the vermis is severely reduced. In the remaining cerebellar structures, the Purkinje cells are poorly developed and mislocalized. PMID: 16943432
    17. Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation. PMID: 17151198
    18. these experiments suggest that OAZ participates in a developmental switch regulating the transition from differentiation to maturation in ORNs. PMID: 17521568
    19. Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia. PMID: 19234145
    20. Neural precursor proliferation is reduced in Zfp423 null cerebellum, especially near the midline. Radial glia are morphologically abnormal. Cell layers appear nearly normal to grossly disorganized. PMID: 17151198

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Within the cerebellum, Zfp423 is expressed in both ventricular and external germinal zones. Transiently expressed in newly differentiating olfactory-receptor neurons.
  • 数据库链接：

    KEGG: mmu:94187

    STRING: 10090.ENSMUSP00000105282

    UniGene: Mm.23452

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