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  4. Recombinant Mouse Zinc finger and BTB domain-containing protein 1 (Zbtb1)

Recombinant Mouse Zinc finger and BTB domain-containing protein 1 (Zbtb1)

  • 中文名称：
    小鼠Zbtb1重组蛋白
  • 货号：
    CSB-YP845978MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Zbtb1重组蛋白
  • 货号：
    CSB-EP845978MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Zbtb1重组蛋白
  • 货号：
    CSB-EP845978MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Zbtb1重组蛋白
  • 货号：
    CSB-BP845978MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Zbtb1重组蛋白
  • 货号：
    CSB-MP845978MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Zbtb1
  • Uniprot No.：
    Q91VL9
  • 别名：
    Zbtb1; Zinc finger and BTB domain-containing protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-713
  • 氨基酸序列
    MAKPSHSSYV LQQLNNQREW GFLCDCCIAI DDIYFQAHKA VLAACSSYFR MFFMNHQHST AQLNLSNMKI SAECFDLILQ FMYLGKIMTA PSSFEQFKVA MNYLQLYNVP DCLEDIQDAD CSSSKCSSSA SSRQSSKMIF GVRMYEDTVA RNGNEANRWC AEPSSTVNTP HHREPEEESL QLANFPEPLF DVCKKSSVSK LSTPKERVSR RFGRSFTCDS CGFGFSCEKL LDEHVLTCTN RHSYQNTTRA YHRIVDIRDG KDSNIKAELA EKDSSKTFSA QPDKYREDAN QAPDDSASTT GSRKSTVEAG IAGEEKSRAT ETKRIIIKME PEDIPADDMK DFNIIKVTEK DCNESTDNDE LEDEPEEPFY RYYVEEDVGI KKSGRKTLKP RMSISVDERG GLENMRPPNN TSPIQEDAEN ASCELCGLTI TEEDLSSHYL AKHIENICAC GKCGQILVKG RQLQEHAQRC GEPQDLTMNG LGNADEKMDM EENPDEQSEI RDMFVEMLDD FRDNHYQINS IQKKQLFKHS ACPFRCPNCG QRFETENLVV EHMSSCLDQD MFKGAIMEEN ERDHRRKHFC NLCGKGFYQR CHLREHYTVH TKEKQFVCQT CGKQFLRERQ LRLHNDMHKG MARYVCSICD QGNFRKHDHV RHMISHLSGG ETICQVCFQI FPNNEQLEQH MDVHLYTCGI CGAKFNLRKD MRSHYNAKHL KRT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development.
  • 基因功能参考文献：
    1. these results show that Zbtb1 expression prevents activation of a default myeloid program in LMPP cells, ensuring the generation of lymphoid cells PMID: 27542215
    2. these results indicate that Zbtb1 prevents DNA damage in replicating immune progenitors, allowing the generation of B cells, T cells, and myeloid cells. PMID: 27402700
    3. Expression of mRNA encoding transgenic Zbtb1, a predicted transcription repressor, is greatest in hematopoietic stem cells, thymocytes, and pre-B cells, highlighting its essential role in lymphoid development PMID: 22753936
    4. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator. PMID: 22201126
  • 亚细胞定位：
    Nucleus. Nucleus, nucleoplasm.
  • 组织特异性：
    Expressed strongly in thymus and spleen, less in lymph nodes and peripheral blood mononuclear cells (PBMCs) and weakly in bone marrow. Strongly expressed in immature, but weakly in mature bone marrow-lymphocyte B.
  • 数据库链接：

    KEGG: mmu:268564

    STRING: 10090.ENSMUSP00000041955

    UniGene: Mm.77065

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