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  4. Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-1 (Cacna2d1), partial

Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-1 (Cacna2d1), partial

  • 中文名称：
    Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-1(Cacna2d1) ,partial
  • 货号：
    CSB-YP004407MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-1(Cacna2d1) ,partial
  • 货号：
    CSB-EP004407MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-1(Cacna2d1) ,partial
  • 货号：
    CSB-EP004407MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-1(Cacna2d1) ,partial
  • 货号：
    CSB-BP004407MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-1(Cacna2d1) ,partial
  • 货号：
    CSB-MP004407MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cacna2d1
  • Uniprot No.：
    O08532
  • 别名：
    Cacna2d1; Cacna2Voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
  • 基因功能参考文献：
    1. Cacna2d1 regulated the intraocular pressure and glaucoma susceptibility. PMID: 29176626
    2. Study identified a critical role for alpha2delta-1 in freeze-lesion-induced developmental cortical malformation pathologies and in mediating the neuroprotective effects of gabapentin (GBP). Genetic deletion of alpha2delta-1 did not eliminate GBP's effects on synaptogenesis, suggesting that GBP can have alpha2delta-1-independent effects. PMID: 29109971
    3. Results show that overexpression of alpha2delta-1 alone in TG mice can enhance excitatory connectivity in neocortex and lead to neural circuit hyperexcitability and episodes of electrographic epileptiform activity, associated with behavioral arrests in transgenic mice. PMID: 28193459
    4. Loss of the Ca(2+) channel alpha2delta-1 subunit function increases the susceptibility for developing diabetes in a sex-dependent manner. PMID: 28115397
    5. Linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Cacna2d1 may contribute to individual differences in von Frey filament response. PMID: 27231153
    6. a TSP4/Cavalpha2delta1-dependent pathway activated by TSP4 or peripheral nerve injury promotes exaggerated presynaptic excitatory input and evoked sensory neuron hyperexcitability and excitatory synaptogenesis. PMID: 27129212
    7. Our findings support a role of peripheral nerve injury-induced alpha2delta1 in enhancing pre-synaptic excitatory PMID: 24151064
    8. These results suggest calcium channel-independent effects of alpha2delta-1 on feeding and implicate alpha2delta-1-thrombospondin interactions known to facilitate excitatory synapse assembly PMID: 24403154
    9. These findings suggest that the alpha(2)delta(4) subunit participates in the modulation of L-type Ca(2+) current regulating neurotransmitter release from photoreceptor terminals PMID: 23296739
    10. alpha2delta-1 is essential for rapid development of mechanical hypersensitivity in a nerve injury model of neuropathic pain. PMID: 24133248
    11. Expression of Cacna2d1 is enhanced in the amygdala in a model of innate anxiety. PMID: 22849384
    12. This study of the rabbit ortholog of dihydropyridine-sensitive calcium channel alpha 2 provides N-terminal sequencing evidence of the cleavage junction of the alpha2 and delta subunits from the preprotein PMID: 1847144
    13. This study demonistrated that Cacna2d1 gene expression in mouse dorsal raphe nucleus PMID: 22534482
    14. The alpha(2) delta(1) subunit, previously described as an L-type auxiliary subunit, complexes with the T-type Ca(v)3.2 (alpha(1H)) subunit in MLO-Y4 cells. PMID: 21638318
    15. Upregulation of alpha(2)/delta subunit of VGCC in the frontal cortex and the limbic forebrain plays a critical role in development of morphine-induced rewarding effect and behavioral sensitization following neuronal plasticity. PMID: 19596051
    16. alpha(2)-delta Type 1 subunit of voltage-gated calcium channels is the major binding protein for pregabalin in the brain and spinal cord. PMID: 16460711
    17. These results indicate that BZDs examined here have the potential to increase L-type HVCC functions mediated via the enhanced expression of alpha2/delta1 subunit after their sustained exposure. PMID: 17949410
    18. The calcium channel alpha2/delta1 subunit in skeletal muscle plays a role in extracellular signalling. The alpha2/delta1 subunit may be crucial for muscle development, muscle repair, and myoblast attachment and migration. PMID: 18063658
    19. mechanism of Cavalpha2delta1-mediated spinal sensitization in which elevated Cavalpha2delta1 causes increased pre-synaptic glutamate release that leads to reduced excitation thresholds of post-synaptic dorsal horn neurons to innocuous stimuli. PMID: 19216737

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Calcium channel subunit alpha-2/delta family
  • 组织特异性：
    Isoform 2A is expressed in skeletal muscle and aorta. Isoform 2B is expressed in brain. Isoform 2C is expressed in heart. Isoform 2D is expressed in heart and smooth muscle. Isoform 2E is expressed in smooth muscle. All five isoforms are expressed in the
  • 数据库链接：

    KEGG: mmu:12293

    STRING: 10090.ENSMUSP00000049457

    UniGene: Mm.159842

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