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  4. Recombinant Mouse VPS10 domain-containing receptor SorCS2 (Sorcs2), partial

Recombinant Mouse VPS10 domain-containing receptor SorCS2 (Sorcs2), partial

  • 中文名称：
    小鼠Sorcs2重组蛋白
  • 货号：
    CSB-YP866808MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sorcs2重组蛋白
  • 货号：
    CSB-EP866808MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sorcs2重组蛋白
  • 货号：
    CSB-EP866808MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sorcs2重组蛋白
  • 货号：
    CSB-BP866808MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sorcs2重组蛋白
  • 货号：
    CSB-MP866808MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sorcs2
  • Uniprot No.：
    Q9EPR5
  • 别名：
    Sorcs2; VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro). Plays a role in the regulation of dendritic spine density in hippocampus neurons. Required for normal neurite branching and extension in response to BDNF. Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation. ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton. Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress.
  • 基因功能参考文献：
    1. Results indicate that hearing loss and hair bundle defects are associated with SorCS2 (Sortilin-related VPS-10 domain containing protein) disruption. PMID: 28346477
    2. SorCS2 is expressed in mesodermally derived tissues such as striated muscle, adipose tissue, ossifying bone and connective tissue. PMID: 26964886
    3. SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis PMID: 15009648
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane. Recycling endosome membrane. Cell junction, synapse, synaptosome. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Cell junction, synapse, postsynaptic density membrane.
  • 蛋白家族：
    VPS10-related sortilin family, SORCS subfamily
  • 组织特异性：
    Detected in Purkinje cells and pyramidal neurons in brain cortex, cerebellum, dentate gyrus, striatum and hippocampus, and in glia cells in dorsal root ganglia (DRG). Not detected in neurons from the dorsal root ganglia. Detected in hair cells and support
  • 数据库链接：

    KEGG: mmu:81840

    STRING: 10090.ENSMUSP00000041828

    UniGene: Mm.34113

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