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  4. Recombinant Mouse V-type proton ATPase 116 kDa subunit a isoform 2 (Atp6v0a2), partial

Recombinant Mouse V-type proton ATPase 116 kDa subunit a isoform 2 (Atp6v0a2), partial

  • 中文名称：
    Recombinant Mouse V-type proton ATPase 116 kDa subunit a isoform 2(Atp6v0a2) ,partial
  • 货号：
    CSB-YP002386MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse V-type proton ATPase 116 kDa subunit a isoform 2(Atp6v0a2) ,partial
  • 货号：
    CSB-EP002386MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse V-type proton ATPase 116 kDa subunit a isoform 2(Atp6v0a2) ,partial
  • 货号：
    CSB-EP002386MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse V-type proton ATPase 116 kDa subunit a isoform 2(Atp6v0a2) ,partial
  • 货号：
    CSB-BP002386MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse V-type proton ATPase 116 kDa subunit a isoform 2(Atp6v0a2) ,partial
  • 货号：
    CSB-MP002386MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atp6v0a2
  • Uniprot No.：
    P15920
  • 别名：
    Atp6v0a2; Atp6n1b; Tj6; V-type proton ATPase 116 kDa subunit a isoform 2; V-ATPase 116 kDa isoform a2; Immune suppressor factor J6B7; ISF; Lysosomal H(+)-transporting ATPase V0 subunit a2; ShIF; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.
  • 基因功能参考文献：
    1. The data provide novel evidence showing that a2V can regulate the apoptotic pathways, an essential testicular feature, and is necessary for efficient spermatogenesis. PMID: 26226211
    2. These observations suggest that a2V plays a crucial role in spermatogenesis by regulating testicular immune responses, and its inhibition in males leads to poor pregnancy outcome in females. PMID: 24623332
    3. Report Atp6v0a2 up-regulation/inflammatory response during preimplantation period of pregnancy may lead to successful pregnancy outcome. PMID: 22454532
    4. Deceased expression of Atp6v0a2 in the various immune cell populations of the spleen and blood suggests that the maternal environment is not supportive to fetus and leads to poor pregnancy outcome in the abortion-prone mating model PMID: 22221850
    5. a2V regulates the delicate cytokine and chemokine networks that coordinate the recruitment of macrophages for successful placental development and growth at the feto-maternal interface. PMID: 21593477
    6. Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO. PMID: 20153292
    7. These results suggest that ISF/ShIF confers stromal cells with enhanced supporting activities for HSCs by modulating Wnt-activity and the extracellular matrix. PMID: 16343424
    8. Data demonstrate the crucial role of early endosomal acidification and V-ATPase/ARNO/Arf6 interactions in the regulation of the endocytic degradative pathway. PMID: 16415858
    9. Immunolocalization demonstrated expression of all 'a' subunits in the proximal tubule and in the intercalated cells of the collecting system. PCR detected mRNAs encoding all four 'a' isoforms with a relative abundance in the following order: a4>a2=a1>a3. PMID: 17595521

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Endosome membrane. Note=In kidney proximal tubules, detected in subapical early endosomes.
  • 蛋白家族：
    V-ATPase 116 kDa subunit family
  • 组织特异性：
    Relatively high expression in kidney and liver. Lower levels in the spleen, testis, and skeletal muscle. Also expressed in the thymus.
  • 数据库链接：

    KEGG: mmu:21871

    STRING: 10090.ENSMUSP00000039737

    UniGene: Mm.1158

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