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  4. Recombinant Mouse Usherin (Ush2A), partial

Recombinant Mouse Usherin (Ush2A), partial

  • 中文名称：
    小鼠Ush2A重组蛋白
  • 货号：
    CSB-YP652408MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ush2A重组蛋白
  • 货号：
    CSB-EP652408MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ush2A重组蛋白
  • 货号：
    CSB-BP652408MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ush2A重组蛋白
  • 货号：
    CSB-MP652408MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ush2A
  • Uniprot No.：
    Q2QI47
  • 别名：
    Ush2A; Gm676; Usherin; Usher syndrome type IIa protein homolog; Usher syndrome type-2A protein homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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Ush2A Proteins

靶点详情

  • 功能：
    Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.
  • 基因功能参考文献：
    1. Expressed in the cells of the outer nuclear layer of the retina and in cochlea. PMID: 12160733
    2. Conservation of usherin is seen at the nucleotide and amino acid level when comparing the mouse and human gene sequences. PMID: 12433396
    3. Binding to fibronectin occurs at the LE domain of usherin. PMID: 16114888
    4. In mouse inner ears usherin is present at the base of the differentiating stereocilia, which make up the mechanosensitive hair bundles receptive to sound PMID: 16301217
    5. Whrn connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1. PMID: 16434480
    6. usherin in photoreceptors is tethered via its C terminus to the plasma membrane and its large extracellular domain projects into the periciliary matrix, where they may interact with the connecting cilium to fulfill important structural or signaling roles PMID: 17360538

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  • 亚细胞定位：
    Cell projection, stereocilium membrane; Single-pass type I membrane protein. Photoreceptor inner segment.; [Isoform 2]: Secreted.
  • 组织特异性：
    Present in the testis, epididymis, oviduct, spleen, submaxillary gland, and small and large intestines. Not detected in the brain, skin, lung, skeletal muscle, cardiac muscle, liver or kidney. Expressed in smooth muscle of the colon and the epididymis. Al
  • 数据库链接：

    KEGG: mmu:22283

    STRING: 10090.ENSMUSP00000050454

    UniGene: Mm.331238

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