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  4. Recombinant Mouse Unconventional myosin-Ie (Myo1e), partial

Recombinant Mouse Unconventional myosin-Ie (Myo1e), partial

  • 中文名称：
    小鼠Myo1e重组蛋白
  • 货号：
    CSB-YP516795MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Myo1e重组蛋白
  • 货号：
    CSB-EP516795MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Myo1e重组蛋白
  • 货号：
    CSB-EP516795MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Myo1e重组蛋白
  • 货号：
    CSB-BP516795MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Myo1e重组蛋白
  • 货号：
    CSB-MP516795MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Myo1e
  • Uniprot No.：
    E9Q634
  • 别名：
    Myo1e; Myr3; Unconventional myosin-Ie; Unconventional myosin 1E
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.
  • 基因功能参考文献：
    1. MYO1E interacts directly with the FAK FERM-kinase linker and induce FAK kinase activity and tyrosine 397 phosphorylation. PMID: 28348210
    2. our data suggests that MYO1E contributes to breast tumor malignancy and regulates the differentiation and proliferation state of breast tumor cells. PMID: 27329840
    3. the LSP1-myosin1e bimolecular complex plays a pivotal role in the regulation of actin cytoskeleton remodeling during Fc gamma receptor-driven phagocytosis. PMID: 25717183
    4. Myo1e regulates TLR4-triggered macrophage spreading, chemokine release, and antigen presentation via MHC class II. PMID: 25263281
    5. Myo1e is a key component contributing to the functional integrity of podocytes. PMID: 23977349
    6. Overexpression of Myo1e can enhance podocyte migration ability, endocytosis, and attachment to the glomerular basement membrane PMID: 24339252
    7. These findings suggest that myo1e represents a component of the slit diaphragm complex and may contribute to regulating junctional integrity in kidney podocytes. PMID: 23761676
    8. depletion of Myo1E causes reduced transferrin endocytosis and a significant delay in transferrin trafficking to perinuclear compartments, demonstrating an integral role for Myo1E in these actin-mediated steps PMID: 22675027
    9. myo1e expression in podocytes is necessary for normal glomerular filtration and that podocyte defects are likely to represent the primary pathway leading to glomerular disease associated with Myo1E mutations. PMID: 22811491
    10. Myo1e plays an important role in podocyte function and normal glomerular filtration. PMID: 19005011

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  • 亚细胞定位：
    Cytoplasm. Cell junction. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 组织特异性：
    Detected in kidney glomeruli (at protein level). Detected in utricle.
  • 数据库链接：

    KEGG: mmu:71602

    STRING: 10090.ENSMUSP00000034745

    UniGene: Mm.249311

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