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  4. Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 13 (Ptpn13), partial

Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 13 (Ptpn13), partial

  • 中文名称：
    小鼠Ptpn13重组蛋白
  • 货号：
    CSB-YP734108MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ptpn13重组蛋白
  • 货号：
    CSB-EP734108MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ptpn13重组蛋白
  • 货号：
    CSB-EP734108MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ptpn13重组蛋白
  • 货号：
    CSB-BP734108MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ptpn13重组蛋白
  • 货号：
    CSB-MP734108MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ptpn13
  • Uniprot No.：
    Q64512
  • 别名：
    Ptpn13; Ptp14; Tyrosine-protein phosphatase non-receptor type 13; EC 3.1.3.48; PTP36; Protein tyrosine phosphatase DPZPTP; Protein tyrosine phosphatase PTP-BL; Protein-tyrosine phosphatase RIP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2.
  • 基因功能参考文献：
    1. contributions of Fap1 to tyrosine kinase inhibitors (TKI)resistance, CML blast crisis, and relapse after TKI discontinuation PMID: 26984787
    2. The data show that the levels of PTPN13 and beta-catenin must be strictly regulated by extracellular signaling to regulate hematopoietic stem cells attachment to the bone marrow niche and the balance between proliferation and quiescence. PMID: 26344907
    3. The study presents a detailed kinetics analysis of the interaction between PTP-BL PDZ2 domain and a peptide mimicking the PDZ binding motif of APC. PMID: 24928580
    4. SDCCAG3 forms a complex with PTPN13. Interaction of SDCCAG3 with PTPN13 is mediated via the FERM domain of PTPN13 and via the N-terminus of SDCCAG3. PMID: 23108400
    5. Data indicate that Bcr-abl increases PTPN13 promoter activity in an Icsbp-dependent manner. PMID: 22891763
    6. Since PTPL1 catalytic activity is important for cell transformation, VCP regulation by PTPL1 might be important for tumorigenesis. PMID: 23018179
    7. These findings demonstrate a key role for PTP-BL in 3T3-L1 and mouse embryo fibroblasts-derived adipocyte differentiation that is independent of its enzymatic activity. PMID: 19782949
    8. Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL PMID: 11884147
    9. With delayed kinetics, ephrinB ligands recruit the cytoplasmic PDZ domain containing protein tyrosine phosphatase PTP-BL and are dephosphorylated. PMID: 11983165
    10. FAP-1 has a role in binding to, and consequently inhibition of, Fas export to the cell surface PMID: 12724420
    11. examination of potential role of PTP-BL in the dynamics of the cortical actin cytoskeleton PMID: 12839623
    12. In alternatively spliced variant structural changes have imp[lications in the functional role of PTP-BL PMID: 14725761
    13. a very mild but significant impairment of motor nerve repair was observed in PTP-BL mutant mice PMID: 15226483
    14. Involved in the regulation of the meiotic cell cycle. PMID: 15371306
    15. PTP-BL facilitates both retinal ganglion cell neurite initiation and survival of activated retinal glia PMID: 15932596
    16. Different pools of PTP-BL-containing protein complexes can be discerned in neuronal cells, reflecting distinct molecular microenvironments in which PTP-BL may exert its function. PMID: 16388334
    17. The interferon consensus sequence-binding protein (ICSBP/IRF8) represses PTPN13 gene transcription in differentiating myeloid cells PMID: 18195016

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 组织特异性：
    Expressed predominantly in kidney and, to a lesser extent, in lung, heart, brain and testis.
  • 数据库链接：

    KEGG: mmu:19249

    STRING: 10090.ENSMUSP00000048119

    UniGene: Mm.3414

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