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  4. Recombinant Mouse Tyrosine-protein kinase Fer (Fer), partial

Recombinant Mouse Tyrosine-protein kinase Fer (Fer), partial

  • 中文名称：
    小鼠Fer重组蛋白
  • 货号：
    CSB-YP008588MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fer重组蛋白
  • 货号：
    CSB-EP008588MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fer重组蛋白
  • 货号：
    CSB-EP008588MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fer重组蛋白
  • 货号：
    CSB-BP008588MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fer重组蛋白
  • 货号：
    CSB-MP008588MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fer
  • Uniprot No.：
    P70451
  • 别名：
    Fer; Fert2Tyrosine-protein kinase Fer; EC 2.7.10.2; Proto-oncogene c-Fer; p94-Fer
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3 according to PubMed:10878010 and PubMed:19159681, but clearly plays a redundant role in STAT3 phosphorylation. According to PubMed:11134346, cells where wild type FER has been replaced by a kinase-dead mutant show no reduction in STAT3 phosphorylation. Phosphorylates TMF1. Isoform 3 lacks kinase activity.
  • 基因功能参考文献：
    1. Sperm from mice targeted with a kinase-inactivating mutation in Fer failed to undergo capacitation-associated increases in tyrosine phosphorylation. PMID: 27226326
    2. levels of FER were elevated in ovarian cancer cell lines relative to those in immortalized normal surface epithelial cells and that suppression of FER attenuated the motility and invasive properties of these cancer cells PMID: 27401557
    3. directed mitochondrial accumulation of FerT endowed nonmalignant cells with tumor-forming ability PMID: 25237066
    4. a critical role of Fer in PDGF-BB-induced STAT3 activation and cell transformation. PMID: 23589302
    5. Fer is a novel inhibitory kinase for neutrophil chemotaxis toward end target chemoattractants through modulation of PI3K activity. PMID: 23355730
    6. FER kinase plays a critical role in oocyte meiotic spindle microtubule dynamics and may have an additional function in GVBD. PMID: 21268181
    7. NRP1 has a role in signaling Sema3A-evoked neuronal death through Fer in cortical neurons PMID: 20133938
    8. Endotoxin-induced leukocyte adhesion and emigration are significantly elevated in Fer-mutant mice relative to wild-type mice and demonstrate an essential role for Fer kinase in regulating inflammation-induced leukocyte emigration. PMID: 11994443
    9. Fer sustains the activation of ERK1/2 and increases the production of VEGF in hypoxic cells PMID: 15567065
    10. FerT coexist in the acroplaxome with phosphorylated cortactin, a regulator of F-actin dynamics PMID: 18985748

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex.; [Isoform 4]: Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Fes/fps subfamily
  • 组织特异性：
    Detected in liver and testis. Isoform 4 is detected only in testis (at protein level). Widely expressed.
  • 数据库链接：

    KEGG: mmu:14158

    STRING: 10090.ENSMUSP00000000129

    UniGene: Mm.151391

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