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  4. Recombinant Mouse Tumor protein 63 (Tp63)

Recombinant Mouse Tumor protein 63 (Tp63)

  • 中文名称：
    小鼠Tp63重组蛋白
  • 货号：
    CSB-YP024091MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tp63重组蛋白
  • 货号：
    CSB-EP024091MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tp63重组蛋白
  • 货号：
    CSB-EP024091MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tp63重组蛋白
  • 货号：
    CSB-BP024091MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tp63重组蛋白
  • 货号：
    CSB-MP024091MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tp63
  • Uniprot No.：
    O88898
  • 别名：
    Tp63; P63; P73l; Tp73l; Trp63; Tumor protein 63; p63; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-680
  • 氨基酸序列
    MNFETSRCAT LQYCPDPYIQ RFIETPAHFS WKESYYRSAM SQSTQTSEFL SPEVFQHIWD FLEQPICSVQ PIELNFVDEP SENGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR KQQVSDSAKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTMPEGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND FNFDMDSRRN KQQRIKEEGE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter. Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
  • 基因功能参考文献：
    1. TAp63 in POMC neurons is one key molecular driver for the sexual dimorphism in energy homeostasis PMID: 29670083
    2. Down-regulation of p63 attenuates liver steatosis in p53 knockout mice and in diet-induced obese mice, whereas the activation of p63 induces lipid accumulation. PMID: 28480888
    3. Low TP63 expression is associated with neoplasms. PMID: 29180475
    4. The results indicate that ZIP10 plays important roles in epidermal development via, at least in part, the ZIP10-zinc-p63 signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis. PMID: 29078349
    5. Notch signaling maintains p63 levels and horizontal basal cell (HBC) dormancy, in contrast to its suppression of p63 expression in other tissues. Additionally, Notch1, but not Notch2, is required to maintain HBC dormancy after selective neuronal degeneration. PMID: 28637720
    6. present study, we provided a role for IDH2 in protection against UVB-induced skin damage and a new connection between IDH2 and DeltaNp63. PMID: 29391208
    7. Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 and IL-33 are key players in the signaling pathways. PMID: 26768665
    8. cells expressing both p63 and p73 exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes. PMID: 27716744
    9. Data suggest that this the selective targeting of genes by tumor suppressor protein p63 (p63) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends. PMID: 28505376
    10. Using a combination of biophysical methods as well as cell and ovary culture experiments the authors explain how TAp63alpha is kept inactive in the absence of DNA damage but causes rapid oocyte elimination in response to a few DNA double strand breaks thereby acting as the key quality control factor in maternal reproduction. PMID: 27021569
    11. p63alpha protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion PMID: 28794159
    12. TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway PMID: 27869165
    13. controls limb development through transcriptional regulation of different target molecules with different roles in the apical ectodermal ridge PMID: 28333962
    14. increased DeltaNp63alpha protein levels facilitate oncogenic transformation in the epidermis as well as in the bile duct. PMID: 27725202
    15. Taken together, these data show that p63 regulates the self-renewal and differentiation of oesophageal stem cells in humans and mice. PMID: 25897018
    16. p63 expression could be detected as early as E8.5 in mouse embryos preceding epidermal commitment. PMID: 26690418
    17. Lack of embryonic brain development was found in p63-knockout mice. PMID: 26359534
    18. Data show that the transcription factor protein 63 (p63) is a master regulator of the transition from the reserve to the active stem cell pool in the epithelium. PMID: 26305958
    19. TAp63gamma is a late marker of myogenic differentiation. PMID: 25790093
    20. Pvrl1 is a bona fide target gene of the transcription factor p63, whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6 PMID: 25387952
    21. Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells. PMID: 25168238
    22. Some miRs control p63 expression, and p63 regulates the miR expression profile in the epidermis. p63 controls miR expression at different levels. PMID: 25168241
    23. p63 antagonizes p53 to promote cellular survival, whereas p73 regulates self-renewal and p53-mediated apoptosis versus senescence. PMID: 24809925
    24. A study evaluating the expression of P63 among basal cell subpopulations of the murine prostate epithelium is reported. PMID: 25210499
    25. The data indicates that p63 long-range enhancer is composed of additive and partly redundant enhancer modules that act to direct robust p63 expression selectively in the basal layer of the epidermis. PMID: 25567987
    26. The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells. PMID: 25503409
    27. Results show that DLX5, p63, Pin1 and FGF8 participate to the same time- and location-restricted regulatory loop essential for apical ectodermal ridge stratification, hence for normal patterning and skeletal morphogenesis of the limb buds. PMID: 24569166
    28. Trp63 is regulated by STAT5 in mammary tissue and subject to differentiation in cancer. PMID: 24692510
    29. Trp63 heterozygosity does not exert tumor protection in virgin HER2 mice also supports the last conclusion, as p63thorn(+/-). PMID: 24440910
    30. TAp63 directly activates both Angiomodulin and Activin-A during embryonic stem cells cardiogenesis while these secreted factors modulate TAp63 gene expression by a feedback loop mechanism. PMID: 24145187
    31. TAp63gamma plays a positive role during endochondral bone formation. PMID: 24294373
    32. The results suggest that Pin1-mediated modulation of DeltaNp63alpha may have a causative role in tumorigenesis. PMID: 24309930
    33. TAp63 levels are positively correlated with TEC senescence but inversely correlated with expression of FoxN1 and FoxN1-regulated thymic epithelial cell differentiation. PMID: 24263106
    34. p63 is an enabling (rather than a barrier) factor for Oct4, Sox2 and Klf4 (OSK) and Oct4 and Sox2 (OS), but not for Oct4 and Klf4 (OK) reprogramming of mouse embryonic fibroblasts. PMID: 24013722
    35. a significant number of oocytes in newborn mice initiate TAp63alpha expression and simultaneously carry meiotic DNA double-strand breaks PMID: 24515437
    36. Suggest role for Scgb1a1(+) cells in the generation of p63(+) cells in the damaged lung parenchyma. PMID: 24134540
    37. These data reveal a role for DeltaNp63 in the transcriptional regulation of DGCR8 to reprogram adult somatic cells into multipotent stem cells. PMID: 24449888
    38. p63 deletion in basal epithelia during pregnancy results in lactation failure via NRG1 signaling. PMID: 24412575
    39. Our findings provide a missing link between DeltaNp63 overexpression and NF-kappaB-mediated inflammation PMID: 24258200
    40. Notch signaling is activated before p63 expression in ectodermal progenitor cells. PMID: 23924630
    41. Epidermal progenitors with high p63 phosphorylation preferentially expand in response to wounding in both full-thickness wound and surface injury models. PMID: 23614751
    42. study reveals a role for insulin/IGF-1 signaling (IIS) in the regulation of p63 activity; study reveals a critical role for IIS-dependent control of p63 activity in coordination of asymmetric divisions and stratification during epithelial morphogenesis PMID: 23906066
    43. analysis of a p63-involved gene regulatory network that is exclusive to the mandible and independent of the dentition PMID: 23809701
    44. Heterozygous missense mutations in TP63 is associated with Ectrodactyly, Ectodermal dysplasia, Clefting syndrome. PMID: 23775923
    45. Fancd2-Ub activates the transcription of the tumor suppressor TAp63, thereby promoting cellular senescence and blocking skin tumorigenesis. PMID: 23806336
    46. We showed co-expression of Cx30 and p63 in developing mouse hair follicles and nail units. PMID: 23219093
    47. p63 has a role in development of stem cells in developing prostate, bladder, and colorectal epithelia PMID: 23620512
    48. TAp63, acting via the Notch pathway, is crucial for the development of the organ of Corti. PMID: 23589895
    49. TAp63 is important in regulating energy metabolism by accumulating in response to metabolic stress and transcriptionally activating Sirt1, AMPKalpha2, and LKB1, resulting in increased fatty acid synthesis and decreased fatty acid oxidation. PMID: 23040072
    50. Data show that PUMA and NOXA are critical for DNA damage-induced, TAp63-mediated primordial follicle oocyte apoptosis. PMID: 23000175

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    P53 family
  • 组织特异性：
    Widely expressed, notably in thymus, prostate, placenta and skeletal muscle, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast and prostate express high levels of DeltaN-type isoforms.
  • 数据库链接：

    KEGG: mmu:22061

    STRING: 10090.ENSMUSP00000110965

    UniGene: Mm.20894

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