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  4. Recombinant Mouse Transmembrane protein 59 (Tmem59), partial

Recombinant Mouse Transmembrane protein 59 (Tmem59), partial

  • 中文名称：
    小鼠Tmem59重组蛋白
  • 货号：
    CSB-YP023860MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tmem59重组蛋白
  • 货号：
    CSB-EP023860MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tmem59重组蛋白
  • 货号：
    CSB-EP023860MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tmem59重组蛋白
  • 货号：
    CSB-BP023860MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tmem59重组蛋白
  • 货号：
    CSB-MP023860MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tmem59
  • Uniprot No.：
    Q9QY73
  • 别名：
    Tmem59; ORF18; Tdcf1; Transmembrane protein 59; Thymic dendritic cell-derived factor 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
  • 基因功能参考文献：
    1. Dcf1 triggers the dendritic spine and synaptic function through the recruitment of Lcn2 and activation of PSD95-NMDAR signaling. PMID: 28058580
    2. The Dcf1 knockout upregulates ATP1B1 expression in the hippocampus and DCF1 interaction with ATP1B1 in astrocytes impaired their structural plasticity. PMID: 29337145
    3. The results of this study revealed that DCF1-KO mice presented a visual behavioral deficit, higher GAD67 levels, and lower electrophysiological activity in V1 via the GABA system. PMID: 29430585
    4. Dcf1 plays an important role in behavior induced by the mushroom body in Drosophila and the dentate gyrus (DG) in mice and provides novel insights into their functions. Dcf1 rescued the optogenetic suppression of behavior by halorhodopsin in transgenic animals. PMID: 28401598
    5. Notably, we observed a significant increase in the ATP concentration in Dcf1(-/-) mice, suggesting a greater demand for energy in the absence of Dcf1. We studied the relationship between Dcf1 and NPY and revealed that Dcf1 plays a critical role in energy balance. PMID: 28377324
    6. This study shows that losing of dendritic cell factor 1 in the nervous system induces a social interaction deficit. PMID: 28202411
    7. MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis. PMID: 22336716
    8. The expression of tmem59 is an important factor contributing to Alzheimer's disease. PMID: 21955788
    9. Overexpression of the dcf1 gene, the NSCs were maintained in undifferentiated status. After the dcf1 gene was silenced, cells tended to differentiate into neurons and astrocytes. PMID: 18365309

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  • 亚细胞定位：
    Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    TMEM59 family
  • 数据库链接：

    KEGG: mmu:56374

    STRING: 10090.ENSMUSP00000030361

    UniGene: Mm.291192

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