Recombinant Mouse Transcription regulator protein BACH2 (Bach2), partial

1. Bach2 interacts with Batf family transcription factors and controls Th2 cell development via binding to the regulatory regions in the Th2 cytokine, Batf and Batf3 gene loci. PMID: 27581382
2. The study demonstrates that Bach2 is a direct repressor of the interleukin-2 gene in CD4 T cells during the immediate early phase of AP-driven activation, thereby playing an important role in the maintenance of immune quiescence in the steady state PMID: 28855027
3. Results suggest that the mTOR-Bach2 cascade regulates proper cell cycle arrest in B cells as well as immunoglobulin gene rearrangement. PMID: 28993481
4. The Bach2-C/EBPbeta gene regulatory network pathway tunes multipotent progenitor commitment to myeloid and lymphoid lineages both under normal conditions and after infection. PMID: 28273455
5. Data (including data from studies using transgenic/knockout mice) suggest that hyperactivated T-lymphocytes induce specific gene expression patterns in alveolar macrophages and dendritic cells; pulmonary alveolar proteinosis phenotype of Bach2-deficient mice is due to Bach2 deficiency in at least two types of immune cells, alveolar macrophages and dendritic cells. PMID: 28916727
6. Data show that B-cell tumour suppressor BTB and CNC homology 2 (Bach2) was significantly downregulated by the loss of NF-kappaB subunit proto-oncogene protein c-rel (c-Rel) . PMID: 26522720
7. In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2. PMID: 28592433
8. this study shows that the transcription factor BACH2 promotes memory CD8+ T cell generation by blocking access to genomic regulatory sites recognized by AP-1 PMID: 27158840
9. this study shows that B cells of lower affinity receive weaker T cell help, which results in higher expression of the transcriptional repressor Bach2 and promotes the development of memory B cells PMID: 27158841
10. Bach2 controls homeostasis of eosinophils via restricting the production of Il-5 in CD4(+) T cells. PMID: 28216546
11. these data also showed that mouse Bach2 mRNA was a novel target of miR-30b. PMID: 26590946
12. PI3K-Akt-mTOR pathway inhibits Bach2 by both repressing its expression and inducing its phosphorylation in B cells. PMID: 26620562
13. Bach2 is suggested to cooperate with HDAC3-containing co-repressor complexes in B cells to regulate the stage-specific expression of Prdm1 by writing epigenetic modifications at the Prdm1 locus. PMID: 26786103
14. These findings demonstrate that BACH2 is a key component of the molecular program of tumor immunosuppression and identify therapeutic targets for the reversal of immunosuppression in cancer. PMID: 26731475
15. Menin binding at the Bach2 locus and the Bach2 expression are decreased in the senescent CD4 T cells. PMID: 24694524
16. The dynamics of Bach2 expression in response to DNA damage shows that it is a highly sensitive responder to transcription-blocking DNA lesions. PMID: 24075570
17. BCL6 and BACH2 cooperate to orchestrate gene expression patterning in Germinal center B cells through both transcriptional and biochemical mechanisms, which collectively determine the proper initiation and timing of terminal differentiation. PMID: 24277074
18. Bach2 enforces T cell quiescence, promotes the development and survival of Treg lineage, restrains aberrant differentiation of Treg cells, and protects against immune-mediated diseases. PMID: 24367030
19. Bach2 is required for the functional maturation of alveolar macrophages and pulmonary homeostasis. PMID: 24127487
20. Data suggest that repression of the Bach2 transcription factor, which results from antigen experience, contributes to predisposition of IgG1 memory B cells to differentiate into plasma cells. PMID: 23850379
21. BACH2 competes with BCL6 for promoter binding and reverses BCL6-mediated repression of p53 and other cell cycle checkpoint-control genes. PMID: 23852341
22. Bach2 suppresses effector memory-related genes to maintain the naive T-cell state while regulating generation of effector-memory T cells. PMID: 23754397
23. findings identify BACH2 as a key regulator of CD4(+) T-cell differentiation that prevents inflammatory disease by controlling the balance between tolerance and immunity PMID: 23728300
24. Heme oxygenase-1, which is known to be regulated by heme, was repressed by both Bach2 and Bach1 in B cells. PMID: 21444915
25. In the absence of Bach2 encoding a transcription factor required for class switch DNA recombination, mouse splenic B cells more frequently and rapidly expressed Blimp-1 and differentiated to IgM plasma cells as compared with wild-type cells. PMID: 20953163
26. activation by oxidative stress promotes apoptosis and interaction with promyelocytic leukemia nuclear bodies PMID: 11923289
27. expression in differentiating neuronal cells PMID: 12204112
28. Bach/small Maf heterodimers, which normally generate transcriptional repressors, were significantly underrepresented in nuclear extracts prepared from maf mutant brains, and Bach proteins fail to accumulate normally in nuclei. PMID: 12556477
29. Results demonstrate that transcription activity associated with PML bodies is selectively repressed by the recruitment of Bach2 around PML bodies. PMID: 15060166
30. Bach2 is a key regulator of antibody response, and research provides insight into the orchestration of class switch recombination and somatic hypermutation during plasma cell differentiation PMID: 15152264
31. Data suggest that Bach2 expression could represent a switch during the process of neuronal differentiation. PMID: 16631738
32. Bach2 represses the expression of Blimp-1 together with MafK in B cells prior to plasma cell differentiation PMID: 17046816
33. An alternative Bach2 promoter was identified within intron 2. PMID: 19159451

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KEGG: mmu:12014

STRING: 10090.ENSMUSP00000103815

UniGene: Mm.491223