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  4. Recombinant Mouse Transcription regulator protein BACH1 (Bach1), Biotinylated

Recombinant Mouse Transcription regulator protein BACH1 (Bach1), Biotinylated

  • 中文名称：
    Recombinant Mouse Transcription regulator protein BACH1 (Bach1), Biotinylated
  • 货号：
    CSB-EP002526MO-B
  • 规格：
    ￥2832
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Bach1
  • Uniprot No.：
    P97302
  • 别名：
    BTB and CNC homolog 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    129.2 kDa
  • 表达区域：
    1-739aa
  • 氨基酸序列
    MSVSESAVFAYESSVHSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTVTLPEEVTVKGFEPLIQFAYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFLKFKFLDSTSEQQECARKKCFSSHCQKADFKFSFSEQKDLEIDEADEFLEKKRVQTPQCDSRRCQGSVKASPPLQDSVSQACQSLCTDKDGALALPSLCPKYRKFQKAFGTDKIRTLESGVRDVHTASVQPNETSELECFGGAQGCADLHVILKCEGMKAAMESEDTEGQDPSPQCPAEQPQGTPLPQDSAGPHGLYSLSALHTYEQSGDVAFAGVQSKTVKTEKPLSRPDAQDEKPSENQDLYLKSSMGPKEDSSSLASEDRSSVEREVAEHLAKGFWSDICSTDSPCQMQLSPTVAKDGPEQGYSQRRSECPWLGIRISESPEPGQRTFTTLSSVNCPFISTLSSEGCSSNLEIGNYDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQDCEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLCQQVCKEAALSPEQIQILAKYSASDCPLSFLISEKGKSTPDGELAFTSVFSVSDVPPTAPPPCGRGSSAASQELVQESPPTTAAAPEQATLLEPCRQSAGISDFCQQMSDKCTTDE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

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Bach1 Proteins

靶点详情

  • 功能：
    Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK. Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway.
  • 基因功能参考文献：
    1. Theraputic effects of Pirfenidone for induced pulmonary fibrosis were involved in Nrf2/Bach1 equilibrium which regulated the capacity of oxidative stress. PMID: 28420366
    2. Data suggest that Abcb10 silencing results in alteration in heme biosynthesis transcriptional profile due to repression by transcriptional regulator Bach1. (Abcb10 = ATP-binding cassette, sub-family B [MDR-TAP], member 10; Bach1 = BTB and CNC homology 1, basic leucine zipper transcription factor 1) PMID: 28808058
    3. This study showed that RANKL favors osteoclastogenesis via attenuation of Nrf2-mediated antioxidant enzyme expression by competing with Bach1 nuclear accumulation. PMID: 27836987
    4. this study provides new insight into the function of iron and Bach1 in erythroblast maturation by using efficacious regimens that can induce severe ID. PMID: 27927768
    5. miR-196a, which binds to the 3'-untranslated region of the transcriptional repressor BTB and CNC homology 1 (Bach1) and regulates its expression, and subsequently leads to higher levels of lung HO-1 mRNA. PMID: 27343195
    6. Bach1 siRNA exerts protective effects against bleomycin-induced pulmonary fibrosis in mice. PMID: 27959382
    7. These results suggest that Bach1 and Bach2 work in a complementary manner to maintain the normal function of the AMs and surfactant homeostasis in the lung. PMID: 27387751
    8. By integrating the chromatin immunoprecipitation and next-generation sequencing data with a comparative analysis of gene expression in Bach1-deficient and wild type immortalized mouse embryonic fibroblasts (iMEFs), study found 35 new genes whose expression was repressed by BACH1. Known functions of some of these genes suggested a role of BACH1 in adipocyte differentiation, which was verified using iMEFs. PMID: 27030212
    9. Bach1 deficiency reduces the severity of osteoarthritis-like changes. This may be due to maintenance of cartilage homeostasis and joint health by antioxidant effects PMID: 26458773
    10. Bach1 suppresses angiogenesis after ischemic injury and impairs Wnt/beta-catenin signaling by disrupting the interaction between beta-catenin and TCF4 and by recruiting histone deacetylase 1 to the promoter of TCF4-targeted genes. PMID: 26123998
    11. Bach1 deficiency and accompanying overexpression of HO-1 did not influence aging or p53 deficiency-driven tumorigenesis. PMID: 25050144
    12. Our results suggest that Bach2 functions with Bach1 and EBF1 to promote B cell development by repressing myeloid genes in common lymphoid progenitor cells PMID: 25344725
    13. HO-1 induction after ischemia was associated to down-regulation of transcriptional repressor Bach-1, and induction of HO-1 when HO enzymatic activity was inhibited was related to worst outcome after brain ischemia. PMID: 23562577
    14. Bach1 deficiency ameliorates TNBS colitis. PMID: 23446334
    15. Our data provide evidence for a critical role of Bach1 in cell transformation and tumor growth induced by activated H-Ras(V12). PMID: 22847612
    16. apoptosis rate was significantly lower at 1 and 2 weeks post-puncture in Bach 1-/- mice PMID: 22832873
    17. Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis PMID: 22875853
    18. Loss of Bach1 is associated with impaired APC development accompanied by defects in downstream T-cell responses and partial protection from experimental autoimmune encephalomyelitis. PMID: 22791292
    19. Bach1 regulates osteoclastogenesis under inflammatory conditions, via both HO-1-dependent and HO-1-independent mechanisms. PMID: 22127667
    20. The p19(ARF)-Bach1 interaction constitutes a regulatory pathway of p53 in parallel with the p19(ARF)-MDM2 pathway. PMID: 22348305
    21. Bach1 depletion resulted in disordered mitotic chromosome alignment, which was rescued by Bach1 mutants lacking the BTB or DNA binding domains, suggesting its transcription-independent mechanism. PMID: 22289179
    22. Results describe the altered gene-expression profiles of Bach1-deficient fibroblasts to identify genes and their genetic interaction implementing cellular senescence in response to oxidative stress. PMID: 21110788
    23. analysis of Bach1-dependent and -independent regulation of heme oxygenase-1 in keratinocytes PMID: 20501657
    24. regulates enhancer availability of heme oxygenase-1 gene; is a critical physiological repressor of ho-1 PMID: 12356737
    25. Bach1 binding to the Maf recognition element in the microlocus control region is blocked by heme in the beta-globin regulation pathway PMID: 14660636
    26. role in repression of heme oxygenase 1 transcription PMID: 14747657
    27. regulation of HO-1 expression, macrophage function, SMC proliferation and neointimal formation PMID: 15743416
    28. Bach1 is a transcriptional repressor of heme oxygenase-1 gene (Hmox-1) and beta-globin gene. PMID: 16824198
    29. These results suggest that heme within a cell regulates the polyubiquitination and degradation of Bach1. PMID: 17682061
    30. Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, beta-globin, and NADP(H) quinone (oxido) reductase1. PMID: 17901053
    31. In the menisci of Bach 1 deficient mice, the anti-oxidative stress activity was considered to be increased by abrogating the suppression of HO-1 expression PMID: 18271013
    32. Bach1 repressively controls myocardial HO-1 expression both in basal and stressed conditions PMID: 18426999
    33. Data show that the expression levels of Bach1 mRNA in the olfactory bulb are significantly higher than other brain areas, those at the cortex showed the lowest activity. PMID: 18555605
    34. Disruption of the Bach1 gene in Apo E knockout mice caused inhibition of atherosclerosis through upregulation of HO-1 PMID: 18633191
    35. Bach1 modulates heme oxygenase-1 expression in the neonatal mouse lung. PMID: 18948842
    36. Because Bach1 is regulated by oxidative stress and heme, these data show that Bach1 connects oxygen metabolism and cellular senescence as a negative regulator of p53. PMID: 19011633
    37. These results suggest that Bach1 deficiency engenders a constitutively higher expression of HO-1 and a dramatic increase in cytoprotection against spinal cord injury. PMID: 19119918
    38. X-ray structure of the mouse Bach1 BTB domain. PMID: 19170764
    39. Bach1 plays an inhibitory role in the cytoprotection of LPS-induced liver injury but not in the kinin-mediated inflammatory edema. PMID: 19282658
    40. IHABP/RHAMM mediates cytoplasmic anchoring of the transcription factor Bach1 PMID: 15809329
    41. Bach1 generates multivalent DNA binding complex through protein-protein interaction mediated by its BTB/POZ domain PMID: 9565602
    42. Bach1 forms a multivalent DNA binding complex and functions as an architectural transcription factor. PMID: 10620011
    43. Bach1 is a repressor of heme oxygenase-1 gene. High levels of heme induce heme oxygenase-1 by inhibiting Bach1. PMID: 12356737
    44. Bach1 is a heme-binding transcription factor. DNA binding activity of Bach1 is inhibited by heme. PMID: 11387216

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, CNC subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:12013

    STRING: 10090.ENSMUSP00000026703

    UniGene: Mm.26147

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