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  4. Recombinant Mouse Transcription factor SOX-6 (Sox6), partial

Recombinant Mouse Transcription factor SOX-6 (Sox6), partial

  • 中文名称：
    小鼠Sox6重组蛋白
  • 货号：
    CSB-YP022434MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sox6重组蛋白
  • 货号：
    CSB-EP022434MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sox6重组蛋白
  • 货号：
    CSB-EP022434MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sox6重组蛋白
  • 货号：
    CSB-BP022434MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sox6重组蛋白
  • 货号：
    CSB-MP022434MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sox6
  • Uniprot No.：
    P40645
  • 别名：
    Sox6; Sox-6; Transcription factor SOX-6; SOX-LZ
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor.
  • 基因功能参考文献：
    1. These data demonstrate functional cooperation between Sox6 and Nfix in regulating MyHC-I expression during prenatal muscle development. PMID: 27880909
    2. Sox6 plays an important role in suppressing cell proliferation and modulating fetal gene expression during postnatal heart development. PMID: 27832192
    3. findings suggest that Sox6 contributes to cell survival by suppressing BMP-4 transcription during neuronal differentiation PMID: 26590087
    4. We found that miR-21 acts as a bidirectional switch in the formation of IPCs by regulating the expression of target and downstream genes (SOX6, RPBJ and HES1). PMID: 26655730
    5. Loss of Trbp function results in upregulation of Sox6. PMID: 26029872
    6. After cell-cycle exit, Sox6 selectively localizes to substantia nigra pars compacta neurons, while Otx2 and Nolz1 are expressed in a subset of ventral tegmental area neurons. PMID: 25127144
    7. miR-499 regulates the proliferation and apoptosis of embryonic stem cells cells in the late stage of cardiac differentiation via its effects on Sox6 and cyclin D1. PMID: 24040263
    8. Its transactivation during chondrogenesis is negatively regulated by Per1 protein. PMID: 23883486
    9. during development, Sox6 functions as a transcriptional suppressor of fiber type-specific and developmental isoform genes to promote functional specification of muscle which is critical for optimum muscle performance and health. PMID: 21985497
    10. These results identify Sox6 as a robust regulator of muscle contractile phenotype and metabolism, and elucidate a mechanism by which functionally related muscle fiber-type specific gene isoforms are collectively controlled. PMID: 21633012
    11. Data show that Stat3 is required for Sox6 expression during neuronal differentiation. PMID: 21094641
    12. Sox6 is necessary for efficient erythropoiesis in adult mice under both basal and stress conditions. PMID: 20711497
    13. Sox6 is required for notochord extracellular matrix sheath formation, notochord cell survival and formation of nuclei pulposi PMID: 12571105
    14. Sox6 overexpression causes cellular aggregation and neuronal differentiation of P19 embryonal carcinoma cells in the absence of tretinoin. PMID: 14988021
    15. Sox6 likely plays an important role in muscle development PMID: 16124007
    16. Perturbations in transcriptional regulation that are coordinated through SOX6 and PDX1 in beta-cells may contribute to the beta-cell adaptation in obesity-related insulin resistance. PMID: 16148004
    17. Sox6 is required for silencing of epsilony globin in definitive erythropoiesis and may have a role in erythroid cell maturation PMID: 16462943
    18. SOX6 may be an important factor in obesity-related insulin resistance PMID: 17412698
    19. Thus, we successfully identified the Sox6 promoter and its core enhancer and characterized the interactions with regulatory transcription factors. PMID: 17433257
    20. Sox6 plays a critical role in the fiber type differentiation of fetal skeletal muscle; the MyHC-beta promoter revealed a Sox consensus sequence that likely functions as a negative cis-regulatory element PMID: 17584907
    21. The data of this study indicated that SOX6 is a central regulator of both progenitor and cortical interneuron diversity during neocortical development. PMID: 19657336

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Highly expressed in testis.
  • 数据库链接：

    KEGG: mmu:20679

    STRING: 10090.ENSMUSP00000072583

    UniGene: Mm.323365

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