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  4. Recombinant Mouse Transcription factor 21 (Tcf21)

Recombinant Mouse Transcription factor 21 (Tcf21)

  • 中文名称：
    小鼠Tcf21重组蛋白
  • 货号：
    CSB-YP023297MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tcf21重组蛋白
  • 货号：
    CSB-EP023297MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tcf21重组蛋白
  • 货号：
    CSB-EP023297MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tcf21重组蛋白
  • 货号：
    CSB-BP023297MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tcf21重组蛋白
  • 货号：
    CSB-MP023297MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tcf21
  • Uniprot No.：
    O35437
  • 别名：
    Tcf21; Pod1; Transcription factor 21; TCF-21; Capsulin; Epicardin; Podocyte-expressed 1; Pod-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-179
  • 氨基酸序列
    MSTGSLSDVE DLQEVEMLDC DSLKVDSNKE FGTSNESTEE GSNCENGSPQ KGRGGLGKRR KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS RLKTTLPWVP PDTKLSKLDT LRLASSYIAH LRQILANDKY ENGYIHPVNL TWPFMVAGKP ENDLKEVVTA NRLCGTTAS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May be involved in the organogenesis of the spleen and heart and in cardiac and coronary artery development. May function in the development and sex differentiation of gonad via transcriptional regulation of AD4BP/SF-1.
  • 基因功能参考文献：
    1. These results suggest that TCF21 contributes to the proinflammatory environment in VIS fat depots and to active ECM remodeling of these depots by regulating IL6 expression and MMP-dependent ECM remodeling in a spatiotemporally coordinated manner. PMID: 29540474
    2. Periostin-expressing myofibroblasts in the heart derive from tissue-resident fibroblasts of the Tcf21 lineage and are necessary for adaptive healing and fibrosis. PMID: 27447449
    3. During normal heart development, spatio-temporal differences in contribution of WT-1 and Tcf21-LacZ + cells to right versus left ventricular myocardium occur parallel to myocardial thickening. PMID: 26390289
    4. TCF21 may have a role regulating the differentiation state of SMC precursor cells that migrate into vascular lesions and contribute to the fibrous cap and more broadly, in view of the association of this gene with human Coronary Artery Disease PMID: 26020946
    5. Our results demonstrate a critical role for Tcf21 in the differentiation and maintenance of podocytes. PMID: 24904088
    6. Data indicate that loss of Pod1/Tcf21 leads to epicardial blistering, increased smooth muscle cell differentiation on the surface of the heart, and a paucity of interstitial fibroblasts, with neonatal lethality. PMID: 22687751
    7. The majority of Tcf21-expressing epicardial cells are committed to the cardiac fibroblast lineage prior to initiation of epicardial epithelial-to-mesenchymal transition. PMID: 22573622
    8. Data show that correct levels of expression of Myf5 and MyoD during mouse craniofacial development result from activation by musculin and TCF21 through direct binding to specific enhancers. PMID: 22318627
    9. epicardin/capsulin/Pod-1 functions as a negative regulator of differentiation of myoblasts through transcription in cell growth arrest and lineage-specific differentiation PMID: 12493738
    10. findings identify MyoR and capsulin as unique transcription factors for the development of specific head muscles PMID: 12493912
    11. cell autonomous and non-cell autonomous roles for Pod1 in the differentiation of specific renal cell lineages that include peritubular interstitial cells and pericytes. PMID: 12619136
    12. Essential for gonadal development, part of a transcriptional network that orchestrates cell fate decisions in gonadal progenitors. PMID: 15289436
    13. Pod-1, which controls androgen receptor transcription and function, may play an important role in the development and function of the testis. PMID: 15919722
    14. Identificaation of differentially expressed genes in glomeruli from Pod1 knockout (KO) mice that die in the perinatal period with multiple renal defects PMID: 16207825
    15. analysis of TCF21 epigenetic regulation in experimental lung and head and neck cancer PMID: 16415157
    16. Pod1 increased E2A binding to a calponin promoter E-box sequence. Overexpression of Pod1 & E2A resulted in increased smooth muscle and myofibroblast gene expression including calponin, SM22alpha, alphaSMA, fibronectin, & connective tissue growth factor. PMID: 17551956
    17. The data suggest that Pod1 may negatively regulate Rxfp2 expression in the developing glomerulus to promote cell proliferation. PMID: 19416211

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed at high levels in lung, kidney, gut, heart, ovary and podocytes (visceral glomerular epithelial cells). Also found in spleen, large intestine, uterus, bladder and testis.
  • 数据库链接：

    KEGG: mmu:21412

    STRING: 10090.ENSMUSP00000053178

    UniGene: Mm.16497

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