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  4. Recombinant Mouse Toll-like receptor 3 (Tlr3), partial

Recombinant Mouse Toll-like receptor 3 (Tlr3), partial

  • 中文名称：
    小鼠Tlr3重组蛋白
  • 货号：
    CSB-YP023602MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tlr3重组蛋白
  • 货号：
    CSB-EP023602MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tlr3重组蛋白
  • 货号：
    CSB-EP023602MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tlr3重组蛋白
  • 货号：
    CSB-BP023602MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tlr3重组蛋白
  • 货号：
    CSB-MP023602MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tlr3
  • Uniprot No.：
    Q99MB1
  • 别名：
    Tlr3; Toll-like receptor 3; CD antigen CD283
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
  • 基因功能参考文献：
    1. Pregnant mice lacking TLR3 in both maternal systemic and placental cells were completely resistant to the hypertension, proteinuria, fetal demise, endothelial dysfunction, splenomegaly, and increases in pro-inflammatory immune cells induced by TLR3 activation. PMID: 30177045
    2. results indicate that TLR3 is the primary molecule which modulates the activation and function of NK cells during the course of Schistosoma japonicum infection in C57BL/6 mice PMID: 30246036
    3. This study demonstrates that the synergistic effect between TLR4 and TLR3 in macrophages is an important determinant in acute lung injury and, more importantly, that TLR3 up-regulation is dependent on TLR4-MyD88-NF-kappaB signaling. PMID: 28198368
    4. Results provide evidence that TLR3 signaling contributes to the dengue virus-induced increase in microglial migration. PMID: 28273893
    5. this study shows that Tlr3 in nasal CD103(+) dendritic cells is involved in immunoglobulin A production PMID: 28612840
    6. these data suggest that TLR3 promotes the clearance of Cm during early and mid-stages of genital tract infection, and that loss of TLR3 is detrimental in the development hydrosalpinx. PMID: 29624589
    7. TLR3 deficiency in Tlr3 KO mice suppressed the development of chronic contact hypersensitivity reactions, suggesting that TLR3 signaling may participate in the pathogenesis of atopic dermatitis. PMID: 28807557
    8. PolyI:C targeted Toll-like receptor 3 with minimal effect on the mitochondrial antiviral-signaling protein pathway. PMID: 29465830
    9. determined whether the depletion of TLR3 modulated hepatic injury in mice and further aimed to provide mechanistic insights into the TLR3-mediated modulation of diet-induced hepatic inflammation and fat accumulation. PMID: 29410095
    10. TLR3 signaling contributes to Wallerian degeneration after peripheral nerve injury by affecting Schwann cell activation. PMID: 27771719
    11. the JAK-STAT pathway provides a cytokine rheostat mechanism, which enables macrophages to fine-tune their responses to multiple, temporally separated infection events involving the TLR3 and TLR7 pathways. PMID: 27405980
    12. These results suggest that testicular innate immune responses to pathogens caused by nano-TiO2 may be involved in the regulatory mechanisms of TAM/TLR3 signaling in testicular Sertoli cells. PMID: 27643721
    13. findings report that RKIP preferentially regulates the TLR3-mediated immune response in macrophages; phosphorylation of RKIP serine 109 is required for RKIP to promote TLR3-mediated signaling and inflammation PMID: 28411188
    14. Furthermore, Leishmania RNA virus 1-induced TLR-3 activation promoted parasite persistence by enhancing macrophage survival through Akt activation in a manner partially dependent on miR-155. PMID: 27593513
    15. Primary tumor-derived exosomal RNAs, which are enriched in small nuclear RNAs, activate TLR3 in lung epithelial cells, consequently inducing chemokine secretion in the lung and promoting neutrophil recruitment. PMID: 27505671
    16. Autophagy contributes to macrophage resistance to Leishmania major. Data, including data from studies in knockout mice, suggest a key resistance mechanism involves endosomal signaling via Tlr3/7/9 in macrophages; macrophages deficient for Tlr3/7/9, Unc93b1, or MyD88 fail to undergo L. major-induced autophagy. (TLR = Toll-like receptor; Unc93b1 = unc-93 homolog B1; MyD88 = myeloid differentiation primary response gene 88) PMID: 28607148
    17. Our study reveals a novel mechanism of TLR3 in regulation of dendritic morphology and provides an explanation for how environmental factors influence mental health. PMID: 27979975
    18. results reveal a novel CD40-dependent regulation of PD-L1 trafficking induced upon TLR3 signaling that dictates its inhibitory activity. PMID: 27911948
    19. This study reveals novel insights into the pathophysiology of epilepsy and the contribution of TLR3 to disease progression. PMID: 28166388
    20. This study suggests that deliberate control of TLR signaling is a key factor in the success of mRNA-driven cellular reprogramming. PMID: 27586271
    21. the activation of TLR3 promotes the loss of RGCs and their axons by elevating Rtca levels in the retina. Also, the results presented in this study show that Rtca regulates JNK3 expression in the retina. PMID: 27727398
    22. identify iNOS/NO as an integral component of IFN-beta production in response to dsRNA in hepatocytes in a pathway that involves the coordinated activities of TLR3/Trif and PKR PMID: 27226571
    23. we found that Aire up-regulated TLR3 expression and modulated the downstream cytokine expression and nuclear factor-kappaB (NF-kappaB) of the TLR3 signaling pathway. PMID: 27916941
    24. synergy of TLR3 and 7 ligands could significantly enhance the function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-kappaB signaling pathway and be used as adjuvant candidate for the development of novel PRRS inactivated vaccine PMID: 27046485
    25. Our findings support a potential regulatory role of TLR3 in alcohol consumption. PMID: 26885867
    26. The results imply that recognition of resident viruses by TLR3 and TLR7 is required for protective immunity during gut inflammation. PMID: 27084119
    27. TRIF-independent pathways can be involved in the downregulation of drug metabolizing enzymes and transporters through TLR4 and 3. JNK-dependent mechanisms likely mediate this downregulation. PMID: 26470915
    28. during Respiratory syncytial virus infection, respiratory macrophages and dendritic cells mediate the production of IL-33 in a TLR-dependent manner PMID: 26603638
    29. TNFalpha-blockade stabilizes local airway hyperresponsiveness during TLR3/4-induced exacerbations in murine model of asthma. PMID: 26494305
    30. Shock wave treatment protects from neuronal degeneration via TLR3 signaling and subsequent TLR4 downregulation in model of ischemic spinal cord injury. PMID: 26508745
    31. The authors confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3-mediated TRIF signaling by using TLR3-deficient mice. PMID: 26793623
    32. The results of the present study indicate that activation of TLR3 by PolyI:C induces the spermatogonial stem cells apoptosis, which implies that viral infection may interfere with the male germ cell development. PMID: 26350376
    33. dsRNA and TLR3 link the earliest events of mammalian skin wounding to regeneration and suggest potential therapeutic approaches for promoting hair neogenesis. PMID: 26253200
    34. Data indicate that calgranulin B (S100A9) is essential for in vivo toll like receptor 3 (TLR3) signaling. PMID: 26385519
    35. Data show that tripartite motif-containing 38 protein (Trim38) deficiency potentiates toll like receptors TLR3/4-mediated signaling in primary immune cells. PMID: 26392463
    36. A comparison of TLR3-and TLR4-stimulated genes. PMID: 26159724
    37. TLR3 that recognizes viral RNA depends on interferon alpha/beta receptor signaling to induce DC maturation. PMID: 26508631
    38. These results increase the understanding of the function of innate receptors in metabolic disorders and implicate TLR3 as a key control system in metabolic regulation. PMID: 25918231
    39. Expression level of TLR3 was upregulated and the phosphorylation level of IRF3 in the nucleus was enhanced in herpes simplex virus type-1-infected mouse neural stem cells. PMID: 25633775
    40. mechanism conversely holds for plasmacytoid DCs that respond to TLR3 ligation when TLR7 pathway is mobilized. PMID: 26255864
    41. TLR3-activation establishes a type I IFN-dependent antiviral program in a dendritic cell subtype playing crucial roles in priming adaptive antiviral immune responses. PMID: 26101320
    42. TLR9 modulates TLR3 expression in Leishmania major-infected macrophages. PMID: 25911242
    43. TLR3 mediated antibody response to Chikungunya virus infection, virus replication and pathology. PMID: 25452586
    44. the ncRNA U1 acts in a TLR3-dependent manner to induce expression of skin barrier repair genes PMID: 25118157
    45. critical for coxsackievirus B4-induced type 1 diabetes PMID: 25422874
    46. results show that TLR3 enhances antigen-independent skin inflammation in the elicitation phase of allergic contact dermatitis PMID: 25229251
    47. Cell surface TLR3 was highly expressed on splenic CD8+ dendritic cells and marginal zone B cells. PMID: 25305318
    48. Ischemic preconditioning-induced ischemic tolerance is mediated by astrocytic TLR3 signaling. PMID: 24914679
    49. TLR-3 seems to participate in the pathogenesis of early acute kidney injury PMID: 24736450
    50. EP3 and TLR3 in conjunctival epithelium play a critical role in regulating ocular surface inflammation. PMID: 24036040

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome.
  • 蛋白家族：
    Toll-like receptor family
  • 组织特异性：
    Highly expressed in lung. After intraperitoneal injection of lipopolysaccharide, highly expressed in brain, heart, kidney, liver, lung and spleen.
  • 数据库链接：

    KEGG: mmu:142980

    STRING: 10090.ENSMUSP00000034056

    UniGene: Mm.33874

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