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  4. Recombinant Mouse Thymidine kinase, cytosolic (Tk1)

Recombinant Mouse Thymidine kinase, cytosolic (Tk1)

  • 中文名称：
    小鼠Tk1重组蛋白
  • 货号：
    CSB-YP023577MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tk1重组蛋白
  • 货号：
    CSB-EP023577MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tk1重组蛋白
  • 货号：
    CSB-EP023577MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tk1重组蛋白
  • 货号：
    CSB-BP023577MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tk1重组蛋白
  • 货号：
    CSB-MP023577MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tk1
  • Uniprot No.：
    P04184
  • 别名：
    Tk1; Tk-1Thymidine kinase; cytosolic; EC 2.7.1.21
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-233
  • 氨基酸序列
    SYINLPTVL PSSPSKTRGQ IQVILGPMFS GKSTELMRRV RRFQIAQYKC LVIKYAKDTR YSNSFSTHDR NTMDALPACM LRDVTQESLG VAVIGIDEGQ FFPDIVDFCE MMANEGKTVI VAALDGTFQR KAFGSILNLV PLAESVVKLT AVCMECFREA AYTKRLGLEK EVEVIGGADK YHSVCRLCYF KKSSAQTAGS DNKNCLVLGQ PGEALVVRKL FASQQVLQYN SAN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. The down-regulation of Tk1 activity unmasks Tk2 deficiency in Tk2-/- mice and correlates with the onset of mtDNA depletion in the brain and the heart. PMID: 20940150
    2. blood cells are less dependent on mitochondrial Tk2 compared with several other tissues; these cells can synthesize deoxyribonucleotides required for mtDNA replication by alternative pathways such as phosphorylation of thymidine by cytosolic Tk1 PMID: 20440651
    3. Alterations in Tk KO mice indicate that the pyrimidine nucleotide salvage pathway is indispensable in vivo. PMID: 12559842
    4. Mutations in the TK1 gene were studied in neonatal transgenic mice treated with AZT. PMID: 15013700
    5. the small colony mutant phenotype in L5178Y lymphoma is not caused by deletion of both Trp53 and thymidine kinase 1 PMID: 15215324

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Thymidine kinase family
  • 数据库链接：

    KEGG: mmu:21877

    STRING: 10090.ENSMUSP00000026661

    UniGene: Mm.2661

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