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  4. Recombinant Mouse Thioredoxin-dependent peroxide reductase, mitochondrial (Prdx3)

Recombinant Mouse Thioredoxin-dependent peroxide reductase, mitochondrial (Prdx3)

  • 中文名称：
    小鼠Prdx3重组蛋白
  • 货号：
    CSB-YP018656MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Prdx3重组蛋白
  • 货号：
    CSB-EP018656MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Prdx3重组蛋白
  • 货号：
    CSB-EP018656MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Prdx3重组蛋白
  • 货号：
    CSB-BP018656MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Prdx3重组蛋白
  • 货号：
    CSB-MP018656MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Prdx3
  • Uniprot No.：
    P20108
  • 别名：
    Prdx3; Aop1; Mer5Thioredoxin-dependent peroxide reductase; mitochondrial; EC 1.11.1.15; Antioxidant protein 1; AOP-1; PRX III; Perioredoxin-3; Protein MER5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    63-257
  • 氨基酸序列
    TPAVTQHAPYFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDITKQISRDYGVLLESAGIALRGLFIIDPNGVVKHLSVNDLPVGRSVEETLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  • 基因功能参考文献：
    1. The importance of mitochondrial Prdx3 in regulating the oxidative stress environment in adipocytes.Loss of Prdx3 leads to decreased pS473 Akt and insulin-stimulated glucose transport. PMID: 28986255
    2. Oxidative stress promotes PRX2 and PRX3 hyperoxidation and attenuates pro-survival signaling in aging chondrocytes. PMID: 26797130
    3. This study showed that from E10.5,Prdx3 showed strong ventral lateral expression. This increased ventral immunotaining persisted until E18.5 but became relatively less striking at later stages. PMID: 25975898
    4. Prx3 plays a crucial role in mitochondrial homeostasis and thereby controls the contractile functions of skeletal muscle. PMID: 25224038
    5. The SirT1 regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase, catalase, peroxiredoxins 3 and 5, thioredoxin 2, thioredoxin reductase 2, and uncoupling protein 2. PMID: 23461683
    6. Prx3 is up-regulated in response to oxidative stress; the maintenance of Prx3 levels in hair cells is a critical factor in their susceptibility to acquired hearing loss. PMID: 23626763
    7. The concerted action of PrxIII and Srx is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1-derived and ER stress-derived ROS in mitochondria. PMID: 22490042
    8. PrxIII in mouse adrenal cortex is inactivated by H(2)O(2) produced by cytochrome P450 enzymes during corticosterone production stimulated by adrenocorticotropic hormone. PMID: 22681886
    9. endogenous Prx3 may play an essential role in maintaining normal characteristics of adipocytes and that defect in Prx3 alters mitochondrial redox state and function. PMID: 21902452
    10. Immunohistochemical analysis revealed segment-specific alterations induced by the ischemic insult. Grx2, Prx3, and Prx6 were highly expressed in proximal tubule cells PMID: 21586322
    11. Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3. PMID: 20929858
    12. Results indicate that PrxIII is not involved in pre-eclamptic development. Instead, PrxIII is an indispensable antioxidant in placentas where oxidative stress exists. PMID: 20716930
    13. This study showed that peroxiredoxin 3 protects pancreatic beta cells from cell stress induced by accumulation of hydrogen peroxide, or the induction of inducible nitric oxide synthase or caspase-9 and -3 by pro-inflammatory cytokines or streptozotocin. PMID: 20807727
    14. Hyperoxia induced the degradation of Prx III in Nrf2-deficient mice but not in wild-type animals, suggesting that, in the absence of a sufficient amount of Srx PMID: 19086807
    15. PRDX3 is a c-Myc target gene that is required to maintain normal mitochondrial function. c-Myc directly activates expression of a mitochondrial peroxiredoxin that is required for Myc-mediated transformation. PMID: 12011429
    16. mitochondrial Prdx3 is an important cellular antioxidant that regulates physiological levels of H(2)O(2) PMID: 12861054
    17. Roles of MER5 function for the oxidative stress responses by intratracheal inoculation of lipopolysaccharide (LPS) to the mice were examined. PMID: 17316558
    18. Expression of 40 proteins, including the antioxidative enzymes peroxiredoxin 1 and 3, glutathione peroxidase 1, and SOD-1, was increased with diabetes, suggesting an adaptive response to oxidative stress associated with this diabetic model. PMID: 17609286
    19. significantly increased following 200 microM mono-(2-ethylhexyl) phthalate treatment PMID: 18077825
    20. Nitrosative stress leads to protein glutathiolation, increased s-nitrosation, and up-regulation of Prx VI, but not Prx II or Prx III in the heart PMID: 18426799
    21. Increased oxidative stress in placentas that were deficient in PrxIII. PMID: 18544346
    22. PrxIII is necessary for macrophages to protect against lipopolysaccharide-induced oxidative stress. PMID: 19155266
    23. Local antioxidant activity of peroxiredoxin 3 may have a role in maintaining cardiac function. PMID: 19230834

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  • 亚细胞定位：
    Mitochondrion. Cytoplasm. Early endosome.
  • 蛋白家族：
    Peroxiredoxin family, AhpC/Prx1 subfamily
  • 组织特异性：
    Housekeeping-type gene preferentially expressed in murine erythroleukemia (MEL) cells.
  • 数据库链接：

    KEGG: mmu:11757

    STRING: 10090.ENSMUSP00000025961

    UniGene: Mm.29821

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