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  4. Recombinant Mouse Tensin-like C1 domain-containing phosphatase (Tenc1), partial

Recombinant Mouse Tensin-like C1 domain-containing phosphatase (Tenc1), partial

  • 中文名称：
    小鼠Tns2重组蛋白
  • 货号：
    CSB-YP807021MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tns2重组蛋白
  • 货号：
    CSB-EP807021MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tns2重组蛋白
  • 货号：
    CSB-EP807021MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tns2重组蛋白
  • 货号：
    CSB-BP807021MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tns2重组蛋白
  • 货号：
    CSB-MP807021MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tns2
  • Uniprot No.：
    Q8CGB6
  • 别名：
    Tns2; Tenc1; Tensin-2; EC 3.1.3.48; C1 domain-containing phosphatase and tensin homolog; C1-TEN; Tensin-like C1 domain-containing phosphatase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin. In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy. Negatively regulates PI3K-AKT pathway activation.
  • 基因功能参考文献：
    1. deficiency causes alteration of actin remodeling and morphological changes in podocytes and subsequent proteinuria PMID: 27246398
    2. Data suggest that Tenc1 (tensin2) contributes to the maintenance of glomerular basement membrane (GBM) structures and that the genetic background influences the severity of nephrotic syndrome. PMID: 23988887
    3. DISC1-Tensin2 colocalisation was most clearly observed in the Purkinje cells of the mouse cerebellum. PMID: 23233134
    4. C1-Ten is a novel protein tyrosine phosphatase (PTPase) of IRS-1 that acts as a mediator to reduce IRS-1 under a catabolic condition, resulting in muscle atrophy. C1-Ten preferentially dephosphorylated Y612 of IRS-1, which accelerated IRS-1 degradation. PMID: 23401856
    5. tensin2 gene of the ICGN mouse possessed an 8-nucleotide deletion mutation in exon 18, leading to a frameshift and giving rise to a terminal codon at a premature position. PMID: 16688531
    6. Variant 3 expression enhanced the proliferation rate in culture and in vivo tumorigenicity in nude mice PMID: 17006924
    7. Results suggest that tensin2 is involved in expression and extension of nephrin, while tensin2 deficiency may result in proteinuria, associated with the loss of slit integrity. PMID: 19129671
    8. Three strains of the ICGN/Oa mice could be identified by the tensin2 mutation using PCR analysis. The homozygous tensin2 mutation is necessary for the ICGN/Oa mice to develop proteinuria-induced CKD. PMID: 19288329

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  • 亚细胞定位：
    Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 组织特异性：
    Low expression levels in anabolic skeletal muscles.
  • 数据库链接：

    KEGG: mmu:209039

    STRING: 10090.ENSMUSP00000129146

    UniGene: Mm.29389

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