Recombinant Mouse Taste receptor type 1 member 3 (Tas1r3), partial

1. T1R3-mediated visceral reception of metabolites is involved in control of carbohydrate and lipid metabolism. PMID: 30192493
2. T1R1/T1R3 modulates the mTOR pathway to regulate milk protein synthesis in the mouse mammary gland in vivo. PMID: 28497545
3. Data, including data from studies with mutant and knockout mice, suggest that Tas1R3 and Tas1R2 are expressed endogenously in osteoclast stem cells; their expression levels parallel robust increase in osteoclast biomarker Ctsk during osteoclast differentiation. Tas1R3 is expressed in undifferentiated bone marrow stromal cells and its expression is maintained during osteogenic differentiation. (Ctsk = cathepsin K) PMID: 29019082
4. results suggest that the T1R3 homomeric sweet taste receptor negatively regulates adipogenesis through Galphas-mediated microtubule disassembly and consequent activation of the Rho/ROCK pathway. PMID: 28472098
5. T1r3 was upregulated in the adipose tissue of wild type mice in response to high fat/low carbohydrate diet, and their expression positively correlated with fat mass and glucose intolerance. PMID: 26884387
6. T1R3 and alpha-gustducin exhibited a stage-dependent expression pattern during mouse development, and a cell-specific pattern during the spermatogenic cycle. PMID: 26589384
7. Low concentration of endogenous GC is necessary and sufficient for induction of T1R3 expression. Higher concentrations may inhibit such induction. This inhibitory effect may be due, at least in part, to a direct action of GC on taste cells. PMID: 26096555
8. T1R1/T1R3 have roles in regulating ERK1/2 and mTORC1 in MIN6 cells PMID: 26168033
9. Taken together, our study raises the possibility that MyoD and Myogenin might control skeletal muscle metabolism and homeostasis through the regulation of T1R3 promoter activity. PMID: 26545778
10. Mice lacking the Tas1r3 taste receptor gene display impaired glucose metabolism. PMID: 26107521
11. Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice PMID: 25529865
12. T1R3 is expressed mainly in beta-cells and the expression levels are different depending upon the nutritional and metabolic conditions. PMID: 24898279
13. In the Tas1r3-/- strain, in addition to disappearance of taste preference for sucrose, glucose tolerance is also substantially reduced, and insulin resistance is observed. PMID: 25775865
14. These data implicate the T1r3 receptor in the sensory detection and transduction of ethanol taste. PMID: 20145204
15. This study demonistrated that the Tlr3 knockot mice consumed only half as much sugar per day as did Wild type mice. PMID: 24384370
16. The results confirm the sweet taste deficits of T1r3 KO mice but demonstrate their ability to develop strong glucose and milder galactose preferences attributed to the postoral actions of these sugars. PMID: 23547138
17. T1R3 and mGluR5 regulate intestinal epithelial cells in a mouse model of total parenteral nutrition PMID: 24497581
18. A complex molecular mechanism involving changes in the properties of both the orthosteric and non-orthosteric sites of T1R1 underlies the determination of ligand specificity in mammalian T1R1/T1R3. PMID: 24214976
19. speculate that TAS1R3 and GNAT3 activators may help infertile men, particularly those that are affected by some of the mentioned inhibitors and/or are diagnosed with idiopathic infertility involving signaling pathway of these receptors PMID: 23818598
20. cell surface G protein coupled receptor (GPCR) TAS1R1-TAS1R3 (T1R1-T1R3) can sense extracellular amino acids, activate MTORC1, and inhibit autophagy PMID: 23222068
21. The findings of this study indicated that T1r3 and Trpm5 play critical roles in carbohydrate-induced dietary obesity. PMID: 22683548
22. findings show that T1R1/T1R3 is an early sensor of amino acid availability; reduced expression of this receptor impairs activation of mTORC1 by amino acids, results in mTORC1 mislocalization, and accelerates autophagy PMID: 22959271
23. examined the function of umami taste receptor, which has a dimeric protein structure composed of Tas1r1 and Tas1r3, as an amino acid sensor PMID: 22189795
24. Data show that that Tas1r1 and Tas1r3 are expressed in murine and human spermatozoa. PMID: 22427794
25. Data suggest that the absence of intestinal microbiota alters expression of (i.e., up-regulates) Tas1r3 and Sglt1 in proximal small intestine, factors associated with increased consumption of nutritive sweet solutions. PMID: 21781379
26. Data sugget that heterodimer of Tas1R1 and Tas1R3 is the fundamental receptor for the sensing amino acids and regulates the amino acid-induced insulin secretion in pancreatic beta-cells. PMID: 21470345
27. Results sugest that K(ATP) channels constitute a major portion of K(+) channels in the T1r3 subset of taste cells. PMID: 21383163
28. These findings provide clear evidence that gut T1R3 receptors are not necessary for sugar-conditioned flavor preferences or sucralose-induced flavor avoidance in mice. PMID: 20926763
29. In mice Tas1r3 genotype does not predict sugar-induced hyperphagia or obesity; sucrose solutions stimulate higher daily intakes than isocaloric fructose; and susceptibility to sugar-induced obesity varies with strain, sugar concentration and sugar type. PMID: 20600198
30. Data show that the absence of Tas1R3 or presence of the non-taster allele in mice predetermines rejection of alcohol. PMID: 20665148
31. The expression of the T1R subtype T1R3, which is essential for the detection of both sugars and amino acids in the gustatory system, in two distinct cell populations of the gastric mucosa, is demonstrated. PMID: 20063013
32. T1R1 and T1R3 combine to function as a broadly tuned L-amino-acid sensor responding to most of the 20 standard amino acids, but not to their D-enantiomers or other compounds PMID: 11894099
33. mice lacking T1r3 showed no preference for artificial sweeteners and had diminished but not abolished behavioral and nerve responses to sugars and umami compounds PMID: 12869700
34. Results show that the candidate sweet taste receptor T1R3 is essential for the recognition and response to the disaccharide trehalose. PMID: 12892531
35. Polymorphisms associated with saccharin preference do not block gene expression, change alternative splicing, or interfere with protein translation in taste tissue. Ile60Thr may influence the ability of the protein to form dimers or bind sweeteners PMID: 14749438
36. This study describes the range of ligand sensitivity of the T1R3 receptor using an in vivo approach and, to our knowledge, is the first genetic mapping study of activity in gustatory nerves PMID: 14999080
37. cysteine-rich region of T1R3 has a role in determining responses to intensely sweet proteins PMID: 15299024
38. An operant conditioning study of "taster" vs. "non-taster" mice was conducted to determine whether the phenotypes are due only to sensory sensitivity. PMID: 15337688
39. Tas1r3 polymorphisms contribute to initial lick responsiveness to low but not high concentrations of sweeteners. PMID: 16135742
40. describe in detail two strategies for the expression and purification of the ligand-binding domain of T1R taste receptors, which are constituents of the sweet and umami taste receptors PMID: 16621970
41. Association between taste perception and alcohol intake, we used three different mutant mice, each lacking a gene expressed in taste buds and critical to taste transduction: alpha-gustducin (Gnat3), Tas1r3 or Trpm5. PMID: 17376151
42. T1R3 functions as a gustatory calcium-magnesium receptor. PMID: 18593862
43. The results rationalize artificial sweetener tastes and off-tastes by showing that at low concentrations, they stimulate the gustatory system through the T1R3 pathway, and at higher concentrations, their aversion is partly mediated by TRPV1. PMID: 18804451
44. Data show that wheat germ agglutinin immunoreactivity is found in the geniculate and petrosal ganglia of transgenic mice. PMID: 18831764
45. T1R3 taste receptor is critical for sucrose but not Polycose taste. PMID: 19091911
46. Report the existence of multiple transduction pathways underlying responses to sugars: a T1R3-independent gurmarin sensitive pathway for sucrose and glucose. PMID: 19211717
47. This study suggested that T1r3 receptors as primary contributors to the nucleus tractus solitarius sweet processing in mice. PMID: 19279151

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KEGG: mmu:83771

STRING: 10090.ENSMUSP00000030949

UniGene: Mm.358792