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  4. Recombinant Mouse Taste receptor type 1 member 2 (Tas1r2), partial

Recombinant Mouse Taste receptor type 1 member 2 (Tas1r2), partial

  • 中文名称：
    小鼠Tas1r2重组蛋白
  • 货号：
    CSB-YP856410MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tas1r2重组蛋白
  • 货号：
    CSB-EP856410MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tas1r2重组蛋白
  • 货号：
    CSB-EP856410MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tas1r2重组蛋白
  • 货号：
    CSB-BP856410MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tas1r2重组蛋白
  • 货号：
    CSB-MP856410MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tas1r2
  • Uniprot No.：
    Q925I4
  • 别名：
    Tas1r2; Gpr71; T1r2; Tr2; Taste receptor type 1 member 2; G-protein coupled receptor 71; Sweet taste receptor T1R2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
  • 基因功能参考文献：
    1. our platform provides in depth analysis of new sweeteners either alone or in competition and/or inhibition studies to fully understand the structure/functional role of ATD region of T1R2 that transpires in the initial binding event prior to sweet taste response. PMID: 30282936
    2. Data suggest that Tas1r2 and Tas1r3 are involved in regulation of Glp1 secretion in enteroendocrine cells; 3DG (3-deoxyglucosone) attenuates high glucose-stimulated Glp1 secretion by antagonizing Tas1r2/Tas1r3 subunits and downstream cAMP signaling. (Tas1r2 = sweet taste receptor subunit Tas1r2; Tas1r3 = sweet taste receptor subunit Tas1r3; Glp1 = glucagon-like peptide-1) PMID: 29277113
    3. Data, including data from studies with mutant and knockout mice, suggest that Tas1R3 and Tas1R2 are expressed endogenously in osteoclast stem cells; their expression levels parallel robust increase in osteoclast biomarker Ctsk during osteoclast differentiation. (Ctsk = cathepsin K) PMID: 29019082
    4. mice lacking T1R2 + T1R3 and controls were tested in a taste discrimination task to determine whether maltodextrins are 1) detectable when both receptor subunits are absent and 2) perceptually distinct from that of sucrose. Some KO mice were only sensitive to the higher Polycose concentrations, implicating potential allelic variation in the putative polysaccharide receptor pathways unmasked by the absence of T1R2+T1R3. PMID: 28768658
    5. results implicate each subunit of the T1R2+T1R3 dimer in the behavioral response to P-containing taste compounds PMID: 28383662
    6. T1R2 plays an important role in glucose homeostasis during diet-induced obesity through the regulation of yet to be identified molecular mechanisms that alter energy disposal and utilization in peripheral tissues. T1r2 was upregulated in the adipose tissue of wild type mice in response to high fat/low carbohydrate diet, and their expression positively correlated with fat mass and glucose intolerance. PMID: 26884387
    7. Mice possess two taste transduction pathways for sugars. One mediates behavioral attraction to sugars and requires an intact T1r2+T1r3. The other mediates cephalic phase insulin release but does not require an intact T1r2+T1r3. PMID: 26157055
    8. human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3 PMID: 25029362
    9. T1R2 and T1R3 knockout mice have increased cortical bone mass and trabecular remodeling. PMID: 24466105
    10. effects of artificial sweeteners on adipose tissue may be largely independent of the classical sweet taste receptors, T1R2 and T1R3 PMID: 24068707
    11. T1R2+3 heterodimer is the principal receptor that mediates taste detection of natural sweeteners, but not of all carbohydrate stimuli. PMID: 22621968
    12. Genetic ablation of the sweet TR protein T1R2 obliterates fructose-induced insulin release and its potentiating effects on glucose-stimulated insulin secretion in vitro and in vivo. PMID: 22315413
    13. the present study provides behavioral evidence for the presence of a glucose polymer taste receptor that is independent of the T1R2+3 heterodimer. PMID: 21940444
    14. These results demonstrate the expression of bitter taste receptors of the T2R family in the mouse and rat gastrointestinal tract PMID: 11854532
    15. behavioral and physiological characterization of T1R1, T1R2, and T1R3 knockout mice PMID: 14636554
    16. analysis of heterodimeric models of the T1R2-T1R3 receptor PMID: 15738209
    17. In the present study, we compared the genomic organization of rodent T2R genes based on the recently completed mouse and rat genomes and examined tissue- and cell-specific expression of T2Rs. PMID: 15886333
    18. Each of the two subunits in the heteromeric T1R2:T1R3 sweet taste receptor binds sweet stimuli though with distinct affinities and conformational changes. PMID: 16271873
    19. T2Rs may regulate GI function via release of regulatory peptides and activation of the vagal reflex pathway. PMID: 18003792
    20. Activation of the mGlu7 receptor produces anxiolytic-like effects via the modulation of the gamma-aminobutyric acid system. PMID: 18690114
    21. T1R2 and T1R3 subunits are individually unnecessary for normal affective licking responses to Polycose: implications for saccharide taste receptors in mice. PMID: 19158407

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family, TAS1R subfamily
  • 组织特异性：
    Expressed mainly in circumvallate and foliate taste papillae.
  • 数据库链接：

    KEGG: mmu:83770

    STRING: 10090.ENSMUSP00000030510

    UniGene: Mm.190612

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