Recombinant Mouse Talin-1 (Tln1), partial

1. Talin-F0 domain binds to Rap1b like canonical Rap1 effectors despite little sequence homology, and disruption of the binding strongly impairs integrin activation, cell adhesion, and cell spreading. PMID: 29170462
2. The mechanical response of talin-1 has been reported. PMID: 27384267
3. Loss of all Tln forms from the heart-muscle cell leads to myocyte instability and a dilated cardiomyopathy. PMID: 28698364
4. expression is markedly suppressed in pathologically activated osteoclasts PMID: 29141864
5. SKAP1 can affect the function of talin in T-cells needed for optimal T-cell/dendritic cell conjugation PMID: 26905930
6. talins are essential for kidney collecting duct development through mechanisms that extend beyond those requiring binding to the beta1 integrin subunit NPxY motif. PMID: 28993400
7. study describes a role for talin in maintaining the homeostasis and survival of the regulatory T (Treg) cell pool PMID: 28515282
8. High Talin expression is associated with epithelial to mesenchymal transition in mammary gland. PMID: 27452517
9. FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner. PMID: 27043085
10. These findings show that talin and kindlin cooperatively activate integrins leading to fibronectin binding and adhesion. PMID: 26821125
11. Binding of vinculin to the R1-R3 region of the talin rod is important for focal adhesion stability. PMID: 26634421
12. Study suggests that phosphatidylinositol 4,5-bisphosphate can have an impact on integrin activation through interaction with talin and Arg995, in a manner which leads to a breakage of the Arg995-Asp723 salt bridge PMID: 26309152
13. Data indicate that talin mechanics are isoform specific so that expression of either talin-1 or talin-2 modulates extracellular rigidity sensing. PMID: 26523364
14. Mice engineered to express only talin1(L325R) in myeloid cells were protected from renal ischemia-reperfusion injury. PMID: 26169939
15. Conformational activation of talin by PREL-1 triggers integrin-mediated cell adhesion. PMID: 25520155
16. Direct methylation of talin, a key regulatory molecule in cell migration, by Ezh2 disrupted the binding of talin to F-actin and thereby promoted the turnover of adhesion structures. PMID: 25751747
17. reduction of talin-beta3 integrin binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding PMID: 24585775
18. Podocyte talin1 is critical for maintaining the integrity of the glomerular filtration barrier. PMID: 24531545
19. As talin engages F-actin, force exerted on the R2R3 helical bundles disrupts RIAM binding and exposes the vinculin binding sites, which recruit vinculin to stabilize the complex. PMID: 23389036
20. Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. PMID: 23266827
21. Talin1 and Rap1 are critical for resorptive function, and their selective inhibition in mature osteoclasts retards pathological bone loss. PMID: 23230271
22. Talin binding to the membrane-proximal NPxY is crucial for connecting alpha5beta1 to the actin cytoskeleton. PMID: 22795696
23. a novel proteolytic product of talin that is regulated by arginylation and a new role of talin in cadherin-dependent cell-cell adhesion. PMID: 22665520
24. Talin1 was concentrated in peripheral focal adhesions while talin2 was observed in both focal and fibrillar adhesions, and knock-down of talin2 compromised fibronectin fibrillogenesis PMID: 22306379
25. Talin-1 is needed to induce LFA-1 extension, corresponding to intermediate affinity & causing neutrophil slow rolling. Talin-1 & kindlin-3 are needed to induce the high-affinity LFA-1 conformation with open headpiece, causing neutrophil arrest. PMID: 22431571
26. We investigated the role of talin-1, kindlin-3, and alpha-actinin-1 in the upregulation of alpha(4)beta(1) integrin affinity and consequent inflammatory leukocyte adhesive events PMID: 21911599
27. talin1 binding to integrin promotes epiblast adhesion and morphogenesis in part by preventing integrin beta1 degradation PMID: 21670148
28. Data from talin crystal structure reveal a novel FERM domain with a linear domain arrangement, plus an additional domain F0 packed against F1. PMID: 20947018
29. Results reveal that calpain-dependent cleavage of talin modulates cell contractile dynamics, which in pericytes may prove instrumental in controlling normal capillary function or microvascular pathophysiology. PMID: 20709086
30. Loss of Talin1 is associated with integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen. PMID: 20923969
31. Endothelial cell talin1 is essential for embryonic angiogenesis. PMID: 21081121
32. Central region of talin has a unique fold that binds vinculin and actin. PMID: 20610383
33. we studied intracellular signaling in SMACs by three-dimensional immunofluorescence microscopic localization of CD3, CD45, talin, phosphotyrosine, Lck and phosphorylated ZAP-70 in T cell-APC conjugates PMID: 12244310
34. we show that the type I phosphatidylinositol phosphate kinase isoform-gamma 661 (PIPKI gamma 661), an enzyme that makes PtdIns(4,5)P(2), is targeted to focal adhesions by an association with talin PMID: 12422220
35. both PIP kinase and integrins bind to the same surface of the talin F3 subdomain PMID: 12782621
36. talin1 initially forms a molecular slip bond between closely packed fibronectin-integrin complexes and the actin cytoskeleton, which can apply a low level of force to fibronectin until many bonds form or a signal is received to activate a force response PMID: 12867986
37. Results report that competition for talin underlies the trans-dominant inhibition of integrin activation. PMID: 15143061
38. Effects of GFP-fused mTalin expression on growth and development of A. thaliana. PMID: 15563618
39. structural model for PIPKIgamma binding to talin at focal adhesions PMID: 15623515
40. vinculin engagement of adhesion receptors first activates talin or alpha-actinin, by provoking structural changes that allow their vinculin binding sites to swing out, which are then sufficient to bind to and activate vinculin PMID: 16407299
41. vinculin binding to talin depends on stability of the helical bundles that make up the talin rod PMID: 16407302
42. Results describe the NMR structure of the talin-1 phosphotyrosine binding domain in complex with the Y644-phosphorylated type Igamma phosphatidylinositol phosphate kinase (PIPKI) gamma fragment (WVpYSPLH). PMID: 16616931
43. These results define a novel role for the I/LWEQ module as the primary adhesion-complex targeting determinant of Talin1. PMID: 16830345
44. These results establish for the first time at least two distinct roles for talin during CR3/alpha(M)beta(2)-mediated phagocytosis, most noticeably activation of the CR3/alpha(M)beta(2) receptor and phagocytic uptake. PMID: 17202407
45. The structure of a complex between talin and the membrane-proximal integrin beta3 cytoplasmic domain is defined and specific contacts between talin and the integrin tail required for activation. PMID: 17218263
46. Talin-1 silencing by shRNA resulted in normal integrin alphaIIb beta3 expression but deficient inside-out alphaIIb beta3 signaling. PMID: 17872456
47. talin is required for the activation and function of mammalian alpha2beta1 and alphaIIbbeta3 integrins in vivo PMID: 18086863
48. talin is required for inside-out activation of platelet integrins in hemostasis and thrombosis PMID: 18086864
49. Upon phosphorylation of Tyr 747 in the beta3 integrin tail, however, Dok1 then binds much more strongly than talin. PMID: 18156175
50. Data report structure of the C-terminal actin-binding domain of talin and show dimerisation is essential for filamentous actin (F-actin) binding. PMID: 18157087

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KEGG: mmu:21894

STRING: 10090.ENSMUSP00000030187

UniGene: Mm.208601