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  4. Recombinant Mouse T-box transcription factor TBX18 (Tbx18)

Recombinant Mouse T-box transcription factor TBX18 (Tbx18)

  • 中文名称：
    小鼠Tbx18重组蛋白
  • 货号：
    CSB-YP861672MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tbx18重组蛋白
  • 货号：
    CSB-EP861672MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tbx18重组蛋白
  • 货号：
    CSB-EP861672MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tbx18重组蛋白
  • 货号：
    CSB-BP861672MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tbx18重组蛋白
  • 货号：
    CSB-MP861672MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tbx18
  • Uniprot No.：
    Q9EPZ6
  • 别名：
    Tbx18; T-box transcription factor TBX18; T-box protein 18
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-613
  • 氨基酸序列
    MAEKRRGSPC SMLSLKAHAF SVEALIGAEK QQQLQKKRRK LATEEAAGAV EDAGCSRSGG AGEHGCSEAD EEAAAPPPAA GAASGPARSC ADAERSCGSR GAAGSCEDGF LQGASPLASP GGSPKGSPVP GLARPGTPLP APQAPRVDLQ GAELWKRFHE IGTEMIITKA GRRMFPAMRV KISGLDPHQQ YYIAMDIVPV DNKRYRYVYH SSKWMVAGNA DSPVPPRVYI HPDSPASGET WMRQVISFDK LKLTNNELDD QGHIILHSMH KYQPRVHVIR KDCGDDLSPI KPVPSGEGVK AFSFPETVFT TVTAYQNQQI TRLKIDRNPF AKGFRDSGRN RMGLEALVES YAFWRPSLRT LTFEDIPGIP KQGNTSSSAL LQGTGNAVPA THPHLLSGSS CSSPAFHLGP NTSQLCSLTP ADYSACARSG LALNRYSTSL AETYSRLTNQ SSETFAPPRT PSYVSVSSNP SVNMSMGGTD GDTFSCPQTS LSMQISGMSP QLQYIMPSPS GNAFAANQTH QSSYNTFRLH SPCALYGYNF STSPKLAASP EKIVSSQGSF LGSSPSGTMT DRQMLPPVEG VHLLSSGGQQ SFFDSRTLGS LTLPSSQVSA HMV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart, the coronary vessels, the ureter, and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area.
  • 基因功能参考文献：
    1. TBX18 gene transduction may facilitate the differentiation of brown adipose-derived stem cell and white adipose-derived stem cellinto pacemakerlike myocardial cells, and brown adipose-derived stem cell may have a higher capacity than white adipose-derived stem cell for this differentiation. PMID: 29568953
    2. The expression of Tbx3 and shox2, the other two important transcription factors in the development of pacemaker cells, was decreased by silencing Tbx18, which suggests that Tbx18 mediates the differentiation of BATSCs into a pacemaker phenotype via these two downstream transcription factors. PMID: 28382491
    3. hypoxia intervention was sufficient to induce the differentiation of Tbx18-positive epicardial cells to coronary vascular smooth muscle cells. PMID: 27456656
    4. Tbx18 does not function redundantly with Tbx2 or Tbx20 in epicardial development. PMID: 27253890
    5. We conclude that exclusion of Tbx18 expression from the developing atria and (right) ventricle is important to achieve normal cardiac left-right patterning and myocardial differentiation, and that Tbx18 is not sufficient to induce full SAN differentiation of chamber cardiomyocytes in fetal mice. PMID: 27180262
    6. Tbx18 is essential to the differentiation and maintenance of the prostate periurethral mesenchyme; it indirectly regulates epithelial differentiation through control of stromal-epithelial signaling. PMID: 27120339
    7. The temporal suppression of Tbx18 gene expression by the hypermethylation of its promoter seems to trigger the differentiation of mesenchymal cells into hypertrophic chondrocytes in the early stages of endochondral ossification. PMID: 25380565
    8. A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues. PMID: 24854998
    9. Tbx18 has a role in normal development of vasculature network and glomerular mesangium in the mammalian kidney PMID: 24727670
    10. Tbx18, a T-box family member highly expressed in the proepicardium, controls critical early steps in coronary development. PMID: 24016759
    11. Tbx18 is required to prepattern mouse ureteric mesenchyme PMID: 23685333
    12. Tbx18 and Wt1 directly bound to the Slug promoter region and regulated Slug expression PMID: 23469079
    13. Tbx18 is dispensable for epicardial development but that a transcriptional activator form of Tbx18 is sufficient to induce premature smooth muscle differentiation of epicardial cells. PMID: 22926762
    14. Tbx18 is dispensable for normal dermal papilla function. PMID: 22992803
    15. Data show that Tbx18- and Wt1-deficient mice additionally exhibit partial pericardial absence. PMID: 22984617
    16. phenotypes result from competition between the ectopically expressed Tbx6 and the endogenously expressed Tbx18 and Tbx15 at the binding sites of target genes PMID: 20832395
    17. SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation. PMID: 20110314
    18. identification of Tbx18 as a candidate gene for osteosarcoma PMID: 12663494
    19. Tbx18 appears to act downstream of Mesp2 and Delta/Notch signaling to maintain the separation of anterior and posterior somite compartments. PMID: 15155583
    20. Expression of Thx18 is correlated in the prospective ureteral mesenchyme with early onset of ureter abnormalities; in this mouse model, the ureteric epithelium does not differentiate into functional urothelium. PMID: 16511601
    21. Mice deficient for Tbx18 fail to form sinus horns from the pericardial mesenchyme and have defective caval veins, whereas the pulmonary vein and atrial structures are unaffected. (Tbx18) PMID: 16709898
    22. Tbx18 interacts with Gata4 and Nkx2-5 and competes Tbx5-mediated activation of the cardiac Natriuretic peptide precursor type a-promoter. Tbx18 down-regulates Tbx6-activated Delta-like 1 expression in the somitic mesoderm in vivo PMID: 17584735
    23. Defects in otic fibrocyte differentiation subordinate to a primary role of Tbx18 in early compartmentalization of the otic mesenchyme and boundary formation between otic fibrocytes and the surrounding otic capsule were severely affected in the mutant. PMID: 18353863
    24. progenitor cells which express the T-box transcription factor Tbx18 migrate onto the outer cardiac surface to form the epicardium, and contribute to myocytes in the ventricular septum and atrial and ventricular walls PMID: 18480752
    25. Tbx18 interacts with Pax3 in the development of the paraxial mesoderm PMID: 18644785
    26. Tbx18 controls the formation of the SAN head from mesenchymal precursors on which Tbx3 subsequently imposes the pacemaker gene program. PMID: 19096026

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:76365

    STRING: 10090.ENSMUSP00000034991

    UniGene: Mm.158789

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