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  4. Recombinant Mouse Syntaxin-binding protein 5 (Stxbp5), partial

Recombinant Mouse Syntaxin-binding protein 5 (Stxbp5), partial

  • 中文名称：
    小鼠Stxbp5重组蛋白
  • 货号：
    CSB-YP810394MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Stxbp5重组蛋白
  • 货号：
    CSB-EP810394MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Stxbp5重组蛋白
  • 货号：
    CSB-EP810394MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Stxbp5重组蛋白
  • 货号：
    CSB-BP810394MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Stxbp5重组蛋白
  • 货号：
    CSB-MP810394MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Stxbp5
  • Uniprot No.：
    Q8K400
  • 别名：
    Stxbp5; Kiaa4253; Llgl3Syntaxin-binding protein 5; Lethal(2) giant larvae protein homolog 3; Tomosyn-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane.
  • 基因功能参考文献：
    1. Data indicate that bidirectional moving tomosyn-1 (Stxbp5) and tomosyn-2 (Stxbp5l) puncta were observed. PMID: 28746398
    2. Mouse Embryonic Stem (mES) cells self-differentiated into arginine vasopressin (AVP) neurons (mES-AVP) that expressed tomosyn and two transmembrane SNARE proteins, including SNAP25 and syntaxin1. Tomosyn negatively regulates arginine vasopressin secretion in embryonic stem cell-derived neurons. PMID: 27732637
    3. PIASgamma-dependent modification of tomosyn-1 with SUMO-2/3 presents a novel mechanism to adapt secretory strength to the dynamic synaptic environment. PMID: 24614299
    4. STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion PMID: 25244094
    5. STXBP5 inhibits endothelial exocytosis and promotes platelet secretion PMID: 25244095
    6. regulates SNARE complex formation and synaptic vesicle fusion. (review) PMID: 21089602
    7. It regulates vesicle fusion. (review) PMID: 19928526
    8. Interacts with SNAP23 and Syntaxin4 and plays a role in Insulin-stimulated GLUT4 translocacion. PMID: 12832401
    9. The interaction between syntaxin4 and Munc18c in adipocytes results in enhancement of insulin-stimulated GLUT4 externalization. PMID: 15690082
    10. In the pancreatic beta-cell, tomosyn negatively regulates insulin exocytosis. PMID: 16505218
    11. Tomosyn-1 is involved in a post-docking event that prepares secretory granules for fusion and is necessary to sustain exocytosis of pancreatic beta-cells in response to insulin secretagogues. PMID: 16787939
    12. Tomosyn inhibits neurotransmitter release by catalyzing oligomerization of the SNARE complex through the N-terminal WD-40 repeat domain in addition to the inhibitory activity of the C-terminal (VAMP)-like domain. PMID: 18936251

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane; Peripheral membrane protein. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane.
  • 蛋白家族：
    WD repeat L(2)GL family
  • 组织特异性：
    Detected in heart, spleen, lung, skeletal muscle, liver and kidney (at protein level). Detected in brain, particularly in the olfactory bulb and in hippocampus. Detected in the tenia tecta and in the piriform layer of the brain cortex.
  • 数据库链接：

    STRING: 10090.ENSMUSP00000123253

    UniGene: Mm.331751

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