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  4. Recombinant Mouse Synemin (Synm), partial

Recombinant Mouse Synemin (Synm), partial

  • 中文名称：
    小鼠Synm重组蛋白
  • 货号：
    CSB-YP765111MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Synm重组蛋白
  • 货号：
    CSB-EP765111MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Synm重组蛋白
  • 货号：
    CSB-EP765111MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Synm重组蛋白
  • 货号：
    CSB-BP765111MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Synm重组蛋白
  • 货号：
    CSB-MP765111MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Synm
  • Uniprot No.：
    Q70IV5
  • 别名：
    Synm; Dmn; Kiaa0353; Synemin; Desmuslin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
  • 基因功能参考文献：
    1. Suggest that synemin contributes to linkage between costameres and the contractile apparatus and that the absence of synemin results in decreased fiber size and increased sarcolemmal deformability and susceptibility to injury. PMID: 25567810
    2. results show that synemin is necessary to maintain membrane integrity and regulates signalling molecules during muscle hypertrophy. PMID: 25179606
    3. alpha-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin PMID: 25447537
    4. synemin gene encodes proteins belonging to the intermediate filament which confer resistance to mechanical stress and modulate cell shape. PMID: 16817202
    5. Dmn is expressed in reactive astrocytes in neurotrauma and interacts differentially with Vim and Gfap. PMID: 17356066
    6. Alpha- and beta-synemin transcripts and their encoded proteins colocalize in neurons, especially in the midbrain and pons. PMID: 17654553
    7. Synemin isoforms during mouse development. PMID: 19124017
    8. These analyses show that synemin transcript and its encoded protein colocalize in the anterior horn cells and that no differences in synemin expression were found in nerve tissue from C57BL/6 or mdx mice. PMID: 19229966

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell junction, adherens junction.
  • 蛋白家族：
    Intermediate filament family
  • 组织特异性：
    Isoform 2 and isoform 3 are detected in adult skeletal muscle, heart and bladder, whereas isoform 1 is only detected in adult bladder (at protein level).
  • 数据库链接：

    KEGG: mmu:233335

    STRING: 10090.ENSMUSP00000073855

    UniGene: Mm.60526

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