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  4. Recombinant Mouse Structural maintenance of chromosomes protein 1B (Smc1b), partial

Recombinant Mouse Structural maintenance of chromosomes protein 1B (Smc1b), partial

  • 中文名称：
    小鼠Smc1b重组蛋白
  • 货号：
    CSB-YP856350MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Smc1b重组蛋白
  • 货号：
    CSB-EP856350MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Smc1b重组蛋白
  • 货号：
    CSB-EP856350MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Smc1b重组蛋白
  • 货号：
    CSB-BP856350MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Smc1b重组蛋白
  • 货号：
    CSB-MP856350MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Smc1b
  • Uniprot No.：
    Q920F6
  • 别名：
    Smc1b; Smc1l2; Structural maintenance of chromosomes protein 1B; SMC protein 1B; SMC-1-beta; SMC-1B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
  • 基因功能参考文献：
    1. a novel function of Smc1beta as a spindle assembly checkpoint participant beyond its role in chromosome cohesion during mouse oocyte meiosis, identified. PMID: 28118058
    2. super resolution microscopy revealed synapsis-associated SYCP1 aberrantly deposited between sister chromatids and on single chromatids in Smc1b-/-Rad21L-/- cells. PMID: 27792785
    3. Data show that structural maintenance of chromosomes protein 1B (Smc1b) is expressed in somatic cells. PMID: 26673124
    4. Together with previous knowledge, three main functions of SMC1b have emerged, which have multiple consequences for spermatocyte biology. PMID: 24385917
    5. We report here evidence from the mouse that partial loss of gene function for either Smc1b or Rec8 causes perturbations in the formation of the synaptonemal complex (SC) and affects both synapsis and recombination between homologs during meiotic prophase PMID: 23408896
    6. SMC1 beta-deficient mice of both sexes are sterile. Male meiosis is blocked in pachytene; female meiosis is highly error-prone but continues until metaphase II. PMID: 15146193
    7. E2F6 silences SMC1beta and STAG3 in somatic cells PMID: 16236716
    8. SMC1beta plays role in oogenesis. PMID: 16258540
    9. In addition to its role in sister chromatid cohesion, Smc1beta determines meiotic chromatin loop organization. PMID: 18180366
    10. A deletion of 16 nucleotides in exon 5 led to a frame-shift, which generated a stop codon at position 761 (amino acid 247) of the Smc1b cDNA in mutant mice. PMID: 19491376
    11. telomere structure protected from DNA rearrangements depends on SMC1beta. PMID: 19841137

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  • 亚细胞定位：
    Nucleus. Chromosome. Chromosome, centromere.
  • 蛋白家族：
    SMC family, SMC1 subfamily
  • 组织特异性：
    Spermatocytes (at protein level). Testis and ovary specific. Not expressed in somatic cells.
  • 数据库链接：

    KEGG: mmu:140557

    STRING: 10090.ENSMUSP00000023068

    UniGene: Mm.182737

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