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  4. Recombinant Mouse Stanniocalcin-2 (Stc2)

Recombinant Mouse Stanniocalcin-2 (Stc2)

  • 中文名称：
    小鼠Stc2重组蛋白
  • 货号：
    CSB-YP022822MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Stc2重组蛋白
  • 货号：
    CSB-EP022822MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Stc2重组蛋白
  • 货号：
    CSB-BP022822MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Stc2重组蛋白
  • 货号：
    CSB-MP022822MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Stc2
  • Uniprot No.：
    O88452
  • 别名：
    Stc2; Stanniocalcin-2; STC-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-296
  • 氨基酸序列
    TDSTNP PEGPQDRSSQ QKGRLSLQNT AEIQHCLVNA GDVGCGVFEC FENNSCEIQG LHGICMTFLH NAGKFDAQGK SFIKDALRCK AHALRHKFGC ISRKCPAIRE MVFQLQRECY LKHDLCSAAQ ENVGVIVEMI HFKDLLLHEP YVDLVNLLLT CGEDVKEAVT RSVQAQCEQS WGGLCSILSF CTSNIQRPPT AAPEHQPLAD RAQLSRPHHR DTDHHLTANR GAKGERGSKS HPNAHARGRT GGQSAQGPSG SSEWEDEQSE YSDIRR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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Stc2 Proteins

靶点详情

  • 功能：
    Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
  • 基因功能参考文献：
    1. results in MTA2 recruitment to the Stc2 promoter, concomitant with agonist-specific epigenetic modifications targeting histone H4 lysine acetylation PMID: 28696214
    2. STC2 is involved in regulating PAPP-A activity during the development of atherosclerosis PMID: 26983002
    3. Stanniocalcin-2 inhibits proteolytic release of IGF and its ability to cause growth retardation upon transgenic overexpression in mice depends on its proteinase inhibitory function. PMID: 25533459
    4. The Stc2 promoter contains multiple putative xenobiotic response elements. PMID: 23269473
    5. These results suggest that the up-regulation of STC2 gene expression resulting from abnormal alpha-klotho-Fgf23 signaling may contribute to limitation of ectopic calcification. PMID: 22285620
    6. These results define a novel molecular function for STC2 as a negative modulator of Store-Operated Calcium Entry and provide the first direct evidence for the regulation of Ca2+ homeostasis by mammalian STC2. PMID: 21746875
    7. STC2 is linked to PERK signalling in acinar cells and has a role in limiting damage during pancreatic injury. PMID: 21545732
    8. induced STC2 expression is an essential feature of survival component of the unfolded-protein response PMID: 15485913
    9. The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. PMID: 18258678

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Stanniocalcin family
  • 组织特异性：
    Found in a variety of tissues including skeletal muscle, small intestine, kidney, liver and brain.
  • 数据库链接：

    KEGG: mmu:20856

    STRING: 10090.ENSMUSP00000020546

    UniGene: Mm.32506

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