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  4. Recombinant Mouse Stabilin-2 (Stab2), partial

Recombinant Mouse Stabilin-2 (Stab2), partial

  • 中文名称：
    小鼠Stab2重组蛋白
  • 货号：
    CSB-YP854520MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Stab2重组蛋白
  • 货号：
    CSB-EP854520MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Stab2重组蛋白
  • 货号：
    CSB-EP854520MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Stab2重组蛋白
  • 货号：
    CSB-BP854520MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Stab2重组蛋白
  • 货号：
    CSB-MP854520MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Stab2
  • Uniprot No.：
    Q8R4U0
  • 别名：
    Stab2; Feel2; Hare; Stabilin-2; Fasciclin; EGF-like; laminin-type EGF-like and link domain-containing scavenger receptor 2; FEEL-2) [Cleaved into: Short form stabilin-2]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed short form also functions as an endocytosis receptor for heparin internalization as well as HA and CS.
  • 基因功能参考文献：
    1. Stab2 recognizes phospatidylserine exposed on apoptotic cells for sensing as an "eat-me" signal. PMID: 27174501
    2. Results show that Stab2 contributes to phosphatidylserine-dependent myoblast fusion and provide new insights into the molecular mechanism by which phosphatidylserine mediates myoblast fusion during muscle growth and regeneration. PMID: 26972991
    3. A dramatic elevation in circulating hyaluronic acid levels in Stab2-deficient mice without any overt phenotype, is reported. PMID: 22371575
    4. Adrenomedullin treatment from day 14 to day 20 promoted the differentiation of stabilin-2-positive endothelial cells. PMID: 21782867
    5. FEEL-1 and this protein are endocytic receptors for advanced glycation end products. PMID: 12473645
    6. mStab-2 might be involved in the clearance of hyaluronan from the lymph or the blood circulation via the network of endothelial sinuses PMID: 14598175
    7. Stabilin-2-mediated aggregation is mediated by homophilic interactions and enhanced in the presence of Ca(2+) and Mg(2+). Interestingly, exogenous addition of FAS1 domains but not EGF-like domains enhances stabilin-2-mediated cell aggregation PMID: 19328203
    8. stabilin-2 contributes to adhesion and homing of circulating stem and progenitor cells to bone marrow. PMID: 19850011

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in endothelial sinuses of liver, lymph nodes, bone marrow, spleen and in specialised structures of eye, heart, brain and kidney. Expression is detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal ce
  • 数据库链接：

    KEGG: mmu:192188

    STRING: 10090.ENSMUSP00000048309

    UniGene: Mm.279611

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