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  4. Recombinant Mouse Solute carrier family 2, facilitated glucose transporter member 3 (Slc2a3), partial

Recombinant Mouse Solute carrier family 2, facilitated glucose transporter member 3 (Slc2a3), partial

  • 中文名称：
    小鼠Slc2a3重组蛋白
  • 货号：
    CSB-YP021553MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc2a3重组蛋白
  • 货号：
    CSB-EP021553MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc2a3重组蛋白
  • 货号：
    CSB-EP021553MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc2a3重组蛋白
  • 货号：
    CSB-BP021553MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc2a3重组蛋白
  • 货号：
    CSB-MP021553MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc2a3
  • Uniprot No.：
    P32037
  • 别名：
    Slc2a3; Glut3; Solute carrier family 2; facilitated glucose transporter member 3; Glucose transporter type 3; brain; GLUT-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
  • 基因功能参考文献：
    1. Study found no differences in mRNA or protein levels of neuronal monocarboxylate transporters (MCTs). Functional analyses revealed that neuronal MCT2 had high catalytic efficiency in Huntington's disease (HD) cells. Ascorbic acid did not stimulate lactate uptake in HD cells; and was unable to inhibit glucose transport in HD cells because they exhibit decreased expression of the neuronal glucose transporter GLUT3. PMID: 29582588
    2. Neonatal hypothyroridism downregulates the expressions of GLUT3 and GLUT8 in the testis of perpubertal mice. PMID: 28471544
    3. GLUT3-mediated glucose utilization and glycogenolysis in platelets promotes alpha-granule release, platelet activation, and postactivation functions. PMID: 28663252
    4. Results define Glut3 to be a rab11-dependent trafficking cargo and suggest that impaired Glut3 trafficking arising from rab11 dysfunction underlies the glucose hypometabolism observed in Huntington's disease PMID: 25526803
    5. Glut3 is a downstream target of mTORC1, and it is critical for oncogenic mTORC1-mediated aerobic glycolysis and tumorigenesis. PMID: 25578782
    6. GLUT3 levels in the brains of scrapie-infected animals was significantly downregulated. PMID: 24243341
    7. knock-down of glucose transporter 3 in embryonic stem cells impaired the beating function of ESC-derived cardiomyocytes, suggesting its potential role in mediating stem cell differentiation PMID: 23615220
    8. Data suggest that co-activation of CREST (calcium-responsive transactivator) and CBP (CREB-binding protein) enhances signaling between p-Creb/AP-1 and p-HIF-1/HRE resulting in up-regulation of Glut3 gene; here, stimulus was cell hypoxia. PMID: 23321477
    9. Recruitment of Creb1-Mecp2 by glut3-(m)CpG contributes towards transactivation, formulating an escape from (m)CpG-induced gene suppression, and thereby promoting developmental neuronal glut3 gene transcription and expression. PMID: 23493374
    10. These observations collectively support a temporal contribution by transcription toward ensuring adequate tissue-specific, developmental (placenta and embryonic brain), and postnatal hypoxic brain GLUT3 expression. PMID: 23193055
    11. In glut3(+/-) mice, a key role of placental Glut3 in mediating transplacental and intraplacental glucose transport was established. PMID: 22700768
    12. Hesperetin and hesperidin downregulate Akt, GLUT3, and GLUT4 of the insulin signaling pathway in Abeta1-42-induced Neuro-2A cells. PMID: 22383310
    13. This study demonistrated that Glut3 haploinsufficiency does not impair brain glucose uptake or utilization. PMID: 21316350
    14. This is the first description of GLUT3 deficiency that forms a possible novel genetic mechanism for pervasive developmental disorders, such as the neuropsychiatric autism spectrum disorders PMID: 19506559
    15. phosphorylated CREB and Sp3 induce GLUT 3 expression in response to development/cell differentiation and neurotransmission PMID: 15054091
    16. crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4, Slc38a2, and Slc2a3) may be a component of the genetic control of nutrient supply and demand during mammalian development PMID: 16365304
    17. Trophectodermal deficiency of GLUT3 adversely affects in vivo embryonic development in th mouse. PMID: 17213475
    18. Male GLUT3(+/-) mice expressed decreased insulin-responsive GLUT4 in white adipose tissue and skeletal muscle sarcolemma. Authors conclude that the GLUT3(+/-) male mice develop adult-onset adiposity with insulin resistance. PMID: 18445753
    19. A single allele of Slc2a3 is sufficient for maintenance of neuronal energy supply, motor abilities, learning and memory, and feeding behavior. PMID: 18780771
    20. GLUT3 is essential for the development of early post-implanted embryos. PMID: 18948350

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection.
  • 蛋白家族：
    Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
  • 组织特异性：
    Detected in brain (at protein level). Highly expressed in brain.
  • 数据库链接：

    KEGG: mmu:20527

    STRING: 10090.ENSMUSP00000032476

    UniGene: Mm.395108

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