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  4. Recombinant Mouse Solute carrier family 2, facilitated glucose transporter member 2 (Slc2a2), partial

Recombinant Mouse Solute carrier family 2, facilitated glucose transporter member 2 (Slc2a2), partial

  • 中文名称：
    小鼠Slc2a2重组蛋白
  • 货号：
    CSB-YP021552MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc2a2重组蛋白
  • 货号：
    CSB-EP021552MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc2a2重组蛋白
  • 货号：
    CSB-EP021552MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc2a2重组蛋白
  • 货号：
    CSB-BP021552MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc2a2重组蛋白
  • 货号：
    CSB-MP021552MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc2a2
  • Uniprot No.：
    P14246
  • 别名：
    Slc2a2; Glut2; Solute carrier family 2; facilitated glucose transporter member 2; Glucose transporter type 2; liver; GLUT-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Facilitative hexose transporter that mediates the transport of glucose and fructose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate.
  • 基因功能参考文献：
    1. GLUT2-mediated glucosamine transport stimulates mouse embryonic stem cell proliferation. PMID: 27311888
    2. the first intracellular loop of GLUT4 contains the retention motif WLGRK, in which W105 plays a prominent role. PMID: 27122188
    3. hypothalamic arcuate nucleus (Arc)POMC-deficient mice, which develop severe obesity and insulin resistance, unexpectedly exhibit improved glucose tolerance and remain protected from hyperglycemia via decreased renal GLUT2 expression and glycosuria. PMID: 26467632
    4. analysis of the different diabetic responses to STZ in two different animal strains, which both have similar initial GLUT2 expressions in beta cells PMID: 25699277
    5. The study demonstrates a previously unrecognized mechanism that controls insulin expression through c-Abl-regulated NKx2.2 and GLUT2. PMID: 24835010
    6. role of SGLT1 and GLUT2 in intestinal glucose transport and sensing PMID: 24587162
    7. GLUT2-dependent control of parasympathetic activity defines a nervous system/endocrine pancreas axis that is critical for beta cell mass establishment. PMID: 24334455
    8. Embryonic stem cells isolated in physiological-glucose media retain a functional Glut2 transporter that is expressed by embryos. PMID: 24167319
    9. in SAMP8 mice, treatment decreased the expression of glucagon, GLUT2, somatostatin and insulin mRNA. PMID: 22411259
    10. Dysglycosylation of GLUT2 is associated with its re-distribution to lipid-raft microdomain in pancreatic beta cells. PMID: 23548572
    11. Intestinal dehydroascorbic acid (DHA) transport is mediated by the facilitative sugar transporters, GLUT2 and GLUT8 PMID: 23396969
    12. In contrast to islets from the most widely used T1D model, the NOD mouse, human islets predominantly express GLUT1 and, to a much lesser extent, GLUT3 on their surface instead of GLUT2. PMID: 22069254
    13. In human enterocytes, GLUT2 was consistently located in basolateral membranes; mice on a low-carbohydrate/high-fat diet for 12 months also exhibited endosomal GLUT2 accumulation and reduced glucose absorption. PMID: 21852673
    14. Our data provide evidence that glucose detection by GLUT2 contributes to the control of food intake by the hypothalamus PMID: 20179244
    15. regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents PMID: 19956534
    16. This transporter is essential for glucose sensing by pancreatic beta-cells, by the hepatoportal sensor and by sensors in the ANS. PMID: 11780755
    17. GLUT2 and GLUT5 could exert complementary roles in adapting the absorption capacity of the intestine to occasional or repeated loads of dietary sugars. PMID: 12937289
    18. Susceptibility of endothelial cells to glucose toxicity may be the result of theincreased expression of GLUT-2. PMID: 15662550
    19. central glucose sensors require glut2 expression in glial cells and couple glial cells and neurons PMID: 16322792
    20. Absence of GLUT2 suppressed the function of central glucose sensors, which control feeding probably by regulating the hypothalamic melanocortin pathway. PMID: 16567520
    21. Alteration of islet morphology and of GLUT2 expression might contribute to the mechanisms of diabetogenesis in NZO mice. PMID: 16804801
    22. GLUT2 overexpression resulted in increased cellular ATP levels, more inhibition of AgRP mRNA and AMPK phosphorylation by glucose, implicating that brain GLUT2 may be important in the regulation of food intake. PMID: 16978589
    23. Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase PMID: 17203215
    24. High glucose transport by the GLUT2 glucose transporter during organogenesis is responsible for the embryopathic effects of maternal diabetes. PMID: 17235524
    25. Both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2. PMID: 17681422
    26. observed a significant decrease in GLUT2 protein expression levels in isolated proximal tubule ((n=10, p<0.01)) of knockout mice PMID: 17762172
    27. Kir6.2(-/-) mice are streptozotocin resistant because of a decrease in streptozotocin transport by GLUT2 in pancreatic beta-cells PMID: 18042662
    28. Acute insulin treatment before sugar intake prevented the insertion of GLUT2 into the brush border membrane of enterocytes. PMID: 18057092
    29. Molecular invalidation of sugar sensing in GLUT2-loop transgenic mice changed multiple aspects of glucose homeostasis, highlighting by a top-down approach, the role of membrane glucose receptors as potential therapeutic targets PMID: 18074013
    30. we propose the increase in insulin recptor A/GLUT2 complexes due to PTP1B deficiency as the molecular mechanism of the increased glucose uptake in the neonatal stage. PMID: 18535291
    31. mRNA expression of GLUT2 varied diurnally in the duodenum, jejunum and ileum mucosa. GLUT2 protein level varied diurnally in duodenum and jejunum, but not in the ileum. PMID: 19082670
    32. endocytosis and degradation of GLUT2 was specific for beta-cells because expression of GLUT2 in 3T3L1 adipocytes remained cell surface localized and did not display a rapid rate of degradation. PMID: 19477941
    33. The regulation of SGLT-1 and GLUT2 by RELM-beta expands the role of gut hormones in short-term AMPK/protein kinase C mediated control of energy balance PMID: 19502416

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
  • 组织特异性：
    In embryo, expressed in endoderm layer of yolk sac and liver primordium.
  • 数据库链接：

    KEGG: mmu:20526

    STRING: 10090.ENSMUSP00000029240

    UniGene: Mm.18443

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