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  4. Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-2 (Atp1a2), partial

Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-2 (Atp1a2), partial

  • 中文名称：
    Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-2(Atp1a2) ,partial
  • 货号：
    CSB-YP754275MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-2(Atp1a2) ,partial
  • 货号：
    CSB-EP754275MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-2(Atp1a2) ,partial
  • 货号：
    CSB-EP754275MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-2(Atp1a2) ,partial
  • 货号：
    CSB-BP754275MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-2(Atp1a2) ,partial
  • 货号：
    CSB-MP754275MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atp1a2
  • Uniprot No.：
    Q6PIE5
  • 别名：
    Atp1a2; Sodium/potassium-transporting ATPase subunit alpha-2; Na(+)/K(+) ATPase alpha-2 subunit; EC 7.2.2.13; Na(+)/K(+) ATPase alpha(+) subunit; Sodium pump subunit alpha-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
  • 基因功能参考文献：
    1. proof of concept study demonstrates that reduced expression of the alpha2 isoform in the spinal cord is protective following spinal cord injury PMID: 28886701
    2. Atp1a2 does contribute to alcohol-related behaviors, but the effect is modest with a clear dependence on sex. PMID: 27814792
    3. Atp1alpha2 is preferentially expressed with Atp1beta2 in T-tubules of cardiac myocytes, forming alpha2beta2 heterodimers. PMID: 27624940
    4. study provides evidence that muscle beta-catenin is crucial for maintenance of resting membrane potential(RMP)of skeletal muscle cells; muscle cells lacking beta-catenin show decreased expression of alpha2 subunit of Na,K-ATPase, a probable mechanism by which beta-catenin regulates RMP and affects normal function of skeletal muscle PMID: 24674304
    5. Heart expression of alpha2 does not play a role in the regulation of basal cardiovascular function or blood pressure; however, heart expression of alpha2 plays a role in the hypertrophic response to pressure overload. PMID: 23436327
    6. Atp1a2 has a more prominent role (vs. Atp1a1) in modulating cardiac myocyte sarcoplasmic reticulum Ca(2+) release. PMID: 22739122
    7. The ouabain-binding site of either the alpha1 or alpha2 Na,K-ATPase subunit does not play an essential role in the development of DOCA-salt hypertension in a mouse model PMID: 22258333
    8. Central sodium chloride causes hypertension in mice. The blood pressure response is mediated by the ouabain-like substance in the brain, specifically by its binding to the alpha(2)-isoform of the Na,K-ATPase. PMID: 21856907
    9. Atp1a2 expression in heart and vascular smooth muscle is not essential for regulation of basal systolic blood pressure. PMID: 21856916
    10. Ion channel NKCC1 and alpha2 Na, K-ATPase played important roles in the inner ear potassium recycling. PMID: 17111813
    11. Both protein and mRNA expression of alpha1 and alpha2 isoforms of Na,K-ATPase and NKCC1 in the lateral wall were dramatically reduced following a long-term deafening PMID: 21094218
    12. The cardiotonic steroid-binding site of the alpha2 Na,K-ATPase plays a role in maintaining normal SBP during pregnancy PMID: 20940714
    13. The Na,K-ATPase alpha(2) subunit is expressed during development when the t-tubules form. These results suggest that the alpha(2) isoform may serve, in part, a physiological role in the muscle t-tubules. PMID: 12397396
    14. Na,K-ATPase alpha2 isoform could be important in the modulation of neuronal activity in the neonate PMID: 12458206
    15. Ca2+ signaling is regulated by the expression of this protein as studied in knockout mice PMID: 12763872
    16. Heterozygote Atp1a2 mutant adult mice showed increased fear/anxiety behavior and enhanced neuronal activity in the amygdala and piriform cortex after conditioned fear stimuli; homozygotes died just post-birth and showed neuronal apoptosis in these regions PMID: 12805306
    17. the alpha2 Na,K-ATPase isozyme mediates ouabain-induced cardiac contractility in mice PMID: 14559919
    18. individual alpha-isoforms of the Na(+)/K(+)-ATPase differ functionally and that the alpha(2)-isoform couples more strongly to activation-relaxation pathways in vascular smooth muscle PMID: 14627611
    19. the alpha2-isoform of Na-K-ATPase mediates the ouabain-induced increase in vascular contractility and could play a role in the development and maintenance of ouabain-induced hypertension. PMID: 15458945
    20. We propose a model for functional coupling between the Na+, K+-ATPase alpha2 subunit and KCC2, which excludes Cl- from the cytosol in respiratory center neurons. PMID: 15564586
    21. Accordingly, in salt-dependent hypertension, EOLC probably increases vascular resistance and blood pressure by reducing alpha2 Na(+) pump activity and promoting Ca(2)(+) entry via NCX in myocytes. PMID: 16166162
    22. Leu-27 and Ala-35 are essential for targeting/tethering Na+ pump alpha2 subunits to plasma membrane (PM) microdomains overlying "junctional" sarco-/endoplasmic reticulum PMID: 16524882
    23. Learning and memory deficits observed in Na,K-ATPase alpha2 and alpha3 mice reveal Na,K-ATPase to be an important factor in the functioning of pathways associated with spatial learning. PMID: 17234593
    24. Present 3D structural model of Atp1a2. PMID: 17552883
    25. double heterozygote deletion of NKCC1 with alpha(2)-Na,K-ATPase demonstrates a striking preservation of hearing threshold both initially and with age. PMID: 17674100
    26. Coupling between the two respiration-related rhythm generators did not function in the normal manner in Atp1a2(-/)(-) mice. PMID: 17690149
    27. FGF23 transgenic mice display differentially expressed transcript levels of several genes (Npt2a, Pdzk1, Atp1a2) essential in renal Pi regulation. PMID: 17911089
    28. differential distribution of alpha-subunits of the Na+/K+-ATPase in subicular interneurones and pyramidal cells PMID: 17947306
    29. studies of the behavioral aspects of alpha1, alpha2, and alpha 3 deficient mice show that haploinsufficiency of both alpha2 and alpha 3 isoforms result in behavioral defects. PMID: 18044013
    30. Our findings support the concept of a subsarcolemmal space where the alpha 2-isoform coupled with Na+-Ca2+ exchanger modulates Ca2+-store function and Ca2+ entry PMID: 18192219
    31. ACTH-induced hypertension is dependent on the ouabain-binding site of the alpha2-Na+-K+-ATPase subunit. PMID: 18487447
    32. Chronic downregulation of Na(+)-K(+)-ATPase alpha(2)-isoform expression by heterozygous knockout increases the pressor response to increased CSF [Na] and activates the brain renin-angiotensin system. PMID: 19244589

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily
  • 数据库链接：

    KEGG: mmu:98660

    STRING: 10090.ENSMUSP00000083077

    UniGene: Mm.207432

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