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  4. Recombinant Mouse Sodium/calcium exchanger 1 (Slc8a1), partial

Recombinant Mouse Sodium/calcium exchanger 1 (Slc8a1), partial

  • 中文名称：
    小鼠Slc8a1重组蛋白
  • 货号：
    CSB-YP021723MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc8a1重组蛋白
  • 货号：
    CSB-EP021723MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc8a1重组蛋白
  • 货号：
    CSB-EP021723MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc8a1重组蛋白
  • 货号：
    CSB-BP021723MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc8a1重组蛋白
  • 货号：
    CSB-MP021723MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc8a1
  • Uniprot No.：
    P70414
  • 别名：
    Slc8a1; Ncx; Sodium/calcium exchanger 1; Na(+)/Ca(2+)-exchange protein 1; Solute carrier family 8 member 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.
  • 基因功能参考文献：
    1. Pin1 serves as a modulator of SERCA2a and Na(2+)/Ca(2+) exchanger 1 Ca(2+) handling proteins, with loss of function resulting in impaired cardiomyocyte relaxation PMID: 29018025
    2. NCX1 (and NCX2) are expressed in neurons that regulate the motility of the gastric fundus. PMID: 26787195
    3. Induced overexpression of NCX1 attenuated pressure overload-induced pathological cardiac remodelling PMID: 27229460
    4. The heterogeneous expression of multiple types of Na(+)/Ca(2+) exchangers and the quantitative differences found in calcium concentration, together with other risk factors specific to dopaminergic neurons such as dopamine oxidation resulting in oxidative stress, may drive these cells to undergo selective degeneration. PMID: 27020658
    5. NCX1 is dispensable for osteoclast differentiation. PMID: 27942992
    6. the functional role of NCX on gastrointestinal motility PMID: 27928109
    7. These results suggested that NCX1 may play an important role in the proper spatial distribution of LTCC and JP2 in T-tubules in the context of pressure-overloading. PMID: 27789286
    8. In this study, authors demonstrate that NCX1 regulates gastric fundus motility. PMID: 27816547
    9. NCX1 and NCX2 play important roles in ileal motility and suggest that NCX1 and NCX2 regulate the motility in the ileum by controlling the sensitivity of smooth muscles to ACh and SP. PMID: 27411318
    10. Data show that transforming growth factor beta1 (TGFbeta1) is a powerful stimulator of both, store operated Ca2+ entry (SOCE) and Na+/Ca2+-exchanger activity in megakaryocytes. PMID: 27441368
    11. dobutamine upregulates of voltage-gated Na+ channel function and Na+ influx-induced activation of the reverse mode of NCX PMID: 26314851
    12. JAK3 deficiency is followed by down-regulation of cytosolic Ca(2+) release, receptor and store operated Ca(2+) entry and Na(+)/Ca(2+) exchanger activity in dendritic cells. PMID: 26279433
    13. Results suggested that down-regulation of hippocampal NCX1 expression is associated with pentylenetetrazole-induced kindling seizure development PMID: 26220386
    14. TRPC3-NCX micro/nanodomain communication as determinant of cardiac contractility and susceptibility to arrhythmogenic stimuli. PMID: 25631581
    15. cellular Ca accumulation hinders spontaneous depolarization in the NCX knockout sinoatrial node, possibly by inhibiting L-type Ca currents. PMID: 26195795
    16. thrombin-induced ERK1/2 activation required NADPH oxidase 2-mediated reactive oxygen species (ROS) production, and reverse-mode NCX inhibitors and NCX1 siRNA suppressed thrombin-induced ROS production PMID: 25979335
    17. NCX1 plays an important role in smooth muscle motility in the mouse distal colon. PMID: 25427675
    18. There is a functional role of sodium-calcium exchanger SLC8A1 in human atrial and atrioventricular nodal conduction as suggested by genetically modified mouse models. PMID: 25055868
    19. Negative regulation of NCX1- mediated renal Ca(2+) absorption by IFNgamma may significantly contribute to the altered Ca(2+) homeostasis in IBD patients and to IBD-associated loss of bone mineral density PMID: 25648899
    20. human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix PMID: 25589784
    21. muscle-specific deletion of the Slc8a1 (NCX1) gene diminished hind-limb pathology in Sgcd(-/-) mice. PMID: 24662047
    22. majority of NCX1KO cells displayed an irregular and a significantly reduced frequency of spontaneous Ca(2+) signals PMID: 23761399
    23. Our results indicated that in AsTg mice, the Ca(2)(+) response to the acid was facilitated in macrophages by a low threshold of ASIC1 and NCX1 molecules and the activity of these channel was possibly regulated by adiponectin. PMID: 24084100
    24. The decrease of miR-1 and increase of AnxA5 appear as important modulators of NCX1 expression and activity during heart failure. PMID: 23436819
    25. NCX1.3 overexpression is associated with abnormal urination owing to enhanced Ca(2+) influx via reverse mode NCX leading to prolonged, propagating spontaneous Ca(2+) release events and potentiation of spontaneous urinary bladder smooth muscle contraction PMID: 23703524
    26. the use of genetic-modified mice for NCX1, NCX2, and NCX3 represents a fruitful strategy to characterize the physiological role exerted by NCX in CNS PMID: 23224882
    27. Functional studies, as well as mRNA and protein expression analyses, revealed that NCX1 and NCX3, but not NCX2, were divergently modulated during OPC differentiation into oligodendrocyte. PMID: 23224890
    28. NCX1 is a key component of certain distinct signaling pathways that activate VSM contraction in response to stretch (i.e., myogenic response) and to activation of certain G-protein-coupled receptors. PMID: 23224892
    29. Toward an understanding of the complete NCX1 lifetime in the cardiac sarcolemma. PMID: 23224893
    30. Inhibition of the reverse NCX1 completely prevents calcium (Ca2+) increase and spheroid formation in the presence of reactive oxygen species (ROS), suggesting that reverse NCX1 is responsible for the bulk of Ca2+ influx. PMID: 22933787
    31. The Akita(ins2) type 1 diabetic model is protected against systolic failure due to increased NCX1 expression via a CXCR4/NF-kappaB pathway. PMID: 22610174
    32. TRPV6, NCX1, and CaBP-9k in the fetal placenta and CaBP-28k in the maternal placenta may play key roles in controlling calcium transport across the placenta during pregnancy. PMID: 22407925
    33. NCX current was recorded from subepicardial (EPI) myocytes and subendocardial (ENDO) myocytes isolated from sham operation (SO) mice and heart failure (HF) mice. PMID: 21750914
    34. We studied the proarrhythmic potential and mechanisms of enhanced NCX activity in transgenic mice with cardiomyocyte-directed overexpression of NCX . PMID: 22327339
    35. We engineered mice in which the phosphomimetic phospholemman S68E mutant (inhibits NCX1 but not Na(+)-K(+)-ATPase) was constitutively overexpressed in a cardiac-specific manner. PMID: 22081699
    36. Data suggest that the CaMKIIdeltaB-induced imbalance between NCX1 and SERCA2 is partially responsible for the disturbance of intracellular Ca(2) homeostasis and the pathological process of heart failure. PMID: 21931829
    37. an increase in the NCX1 mRNA due to the apoptosis induction is not regulated by HIF-1alpha PMID: 21613675
    38. A single amino acid substitution in Ncx1 results in circulation defects and defective placentation. Action potentials and the Ca2+ homeostasis were diminished so that cardiomyocytes derived from mutant embryos were fibrillating and contracting randomly. PMID: 21302256
    39. Specific genetic knockdown of NCX attenuated calcium mediated afterdepolarization and complex electrogram. PMID: 21168206
    40. Sodium inactivation and reverse sodium-calcium-ion (Ca2+) exchange modulate divalent Ca2+- release in Ncx-deficient cardiomyocytes by triggering ryanodine receptors. PMID: 20643777
    41. Under catecholamine stress when [Na+]i is high, phospholemman minimizes [Na+]i overload by relieving its inhibition of Na+-K+-ATPase and preserves inotropy by simultaneously inhibiting Na+/Ca2+ exchanger. PMID: 21193587
    42. Myocardial NCX1 does not mediate changes in blood pressure, but is one of the mediators for left ventricular global dysfunction and cardiomyocyte injury in chronic intermittent hypoxia. PMID: 20947716
    43. Functional coupling between the vascular alpha2 Na(+) pump and NCX1 is a critical molecular mechanism for salt-induced blood pressure elevation. (review) PMID: 21048395
    44. The Ncx-1-43LUC mES cell line is a novel tool for monitoring early cardiac differentiation in vivo using noninvasive bioluminescence imaging. PMID: 20109065
    45. in NCX1(SM-/-) myocytes, reduced Ca(2+) entry via NCX1 lowers cytosolic calcium, thereby reducing protein kinase C activation that lowers L-type Ca2+ channel activation PMID: 20081108
    46. In NCX1(SM-/-) mouse artery myocytes, the reduced Ca(2+) entry via NCX1 may lower cytosolic Ca concentration and thereby reduce muscle tonus and blood pressure PMID: 20173044
    47. This work has provided insight into the intracellular signaling pathways and transcription factors regulating Ncx1 gene expression in a chronically beta-AR-stimulated heart. PMID: 19945464
    48. Results show that the Na(+)/Ca(2+) exchanger NCLX is enriched in mitochondria, where it is localized to the cristae. PMID: 20018762
    49. The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides in embryonic mouse myocytes PMID: 11861419
    50. Plasma membrane Ca2+-ATPase and NCX1 Na+/Ca2+ exchanger expression in distal convoluted tubule cells mediate calcium efflux. PMID: 12060584

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC8 subfamily
  • 组织特异性：
    Detected in heart, kidney and brain (at protein level).
  • 数据库链接：

    KEGG: mmu:20541

    STRING: 10090.ENSMUSP00000083725

    UniGene: Mm.265834

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