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  4. Recombinant Mouse Sodium- and chloride-dependent taurine transporter (Slc6a6), partial

Recombinant Mouse Sodium- and chloride-dependent taurine transporter (Slc6a6), partial

  • 中文名称：
    小鼠Slc6a6重组蛋白
  • 货号：
    CSB-YP021704MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc6a6重组蛋白
  • 货号：
    CSB-EP021704MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc6a6重组蛋白
  • 货号：
    CSB-EP021704MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc6a6重组蛋白
  • 货号：
    CSB-BP021704MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc6a6重组蛋白
  • 货号：
    CSB-MP021704MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc6a6
  • Uniprot No.：
    O35316
  • 别名：
    Slc6a6; Taut; Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.
  • 基因功能参考文献：
    1. Circulating levels of GDF15 were elevated in old slc6a6 knockout mice PMID: 29491220
    2. These findings suggest that TauT protein expression is relatively insensitive to changes in muscle taurine content in WT and mdx mice, and that taurine and beta-alanine supplementation may be viable therapeutic strategies to improve fatigue resistance of dystrophic skeletal muscle. PMID: 27444300
    3. This study evaluated the role of taurine and its transporter on pancreatic islet cells and insulin secretion. PMID: 28572444
    4. both homozygous and heterozygous TauT gene deletion predispose C57BL/6 mice to develop end-stage diabetic kidney disease PMID: 25629817
    5. This study demonistrated that intracellular taurine deficits lead in particular to a hyposensitivity of nociceptive sensory neurons sensitive to noxious chemical stimulation. PMID: 24321512
    6. Studied protective effect of taurine associated with the upregulation of TAUT expression in acute myocardial ischemia. Data showed that taurine reversed the apoptosis induced by hypoxia and AMI, thereby, effectively protecting the myocardium. PMID: 23381576
    7. Acute exposure to ROS reduces taurine uptake as a result of modulated TauT transport kinetics. PMID: 22383044
    8. Effective T-cell recall responses require the taurine transporter Taut. PMID: 22531910
    9. study represents the first characterization of TauT in neural precursor cells PMID: 21160187
    10. data suggest TauT plays a critical role in renal function; expression of TauT is negatively regulated by p53 and positively regulated by c-Jun; outcome level of TauT may determine the fate of renal cells during stress-induced acute kidney injury PMID: 20804603
    11. All taut-/- mice succumb to infections during crisis, while about 90% of the control taut(+/+) mice survive. PMID: 20100858
    12. The retinal involvement identifies the taurine transporter as an important factor for the development and maintenance of normal retinal functions and morphology. PMID: 11772953
    13. decreased sensitivity of mature erythrocytes from taut-/- mice to osmotic shock and oxidative stress, rendering them more resistant to apoptosis PMID: 14631140
    14. Knockout of the taurine transporter identifies taurine transport as a crucial factor for the maintenance of skeletal muscle function and total exercise capacity, while cardiac muscle apparently can compensate for the loss of taurine. PMID: 14734644
    15. in NIH3T3 cells active taurine uptake reflects TauT expression TauT activity is modulated by multiple stimuli; the subcellular localization of TauT is regulated; and volume-sensitive taurine release is not mediated by TauT PMID: 15606752
    16. Murine TAUT is regulated in response to hypertonicity and taurine-rich conditions. PMID: 15630240
    17. TauT localizes to the primary cilium of growth-arrested NIH3T3 fibroblasts PMID: 15914036
    18. Taut-/- mice suffer from renal taurine loss and impaired ability to lower urine osmolality and to increase urinary water excretion. PMID: 16249932
    19. Apoptotic liver damage develops as a consequence of taurine deficiency due to taurine transporter knockout mutation. PMID: 16421246
    20. TAUT is responsible for taurine uptake in mouse cerebrocortical neurons, and that the expression of TAUT is increased with developing cerebrocortical neurons PMID: 16550472
    21. Results describe the gene expressions of taurine transporter and taurine biosynthetic enzyme during mouse and chicken embryonic development. PMID: 17153590
    22. Data show that myogenic induction of the taurine transporter prevents dexamethasone-induced muscle atrophy. PMID: 17153611
    23. Furthermore, taut-/- and taut+/- mice develop moderate unspecific hepatitis and liver fibrosis beyond 1 year of age where hepatocyte apoptosis and activation of the CD95 system are pronounced. PMID: 17459327
    24. In a TAUT-deficient model, lack of taurine in the skin was found to cause a significantly higher sensitivity to ultraviolet B-induced immunosuppression. PMID: 17785795
    25. Lack of taurine leads to reduced sensitivity of synaptic and extrasynaptic GABAA receptors and consequently to disinhibition in Taut knockout mice PMID: 17962336
    26. Multiple actions of taurine, including osmoregulation, regulation of mitochondrial protein expression and inhibition of apoptosis, collectively ensure proper maintenance of cardiac and skeletal muscular structure and function. PMID: 18407290
    27. critical role in protecting against cisplatin-induced nephrotoxicity, possibly by attenuating a p53-dependent pathway PMID: 19423693

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A6 subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:21366

    STRING: 10090.ENSMUSP00000032185

    UniGene: Mm.395650

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