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  4. Recombinant Mouse Sodium- and chloride-dependent creatine transporter 1 (Slc6a8), partial

Recombinant Mouse Sodium- and chloride-dependent creatine transporter 1 (Slc6a8), partial

  • 中文名称：
    小鼠Slc6a8重组蛋白
  • 货号：
    CSB-YP848666MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc6a8重组蛋白
  • 货号：
    CSB-EP848666MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc6a8重组蛋白
  • 货号：
    CSB-EP848666MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc6a8重组蛋白
  • 货号：
    CSB-BP848666MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc6a8重组蛋白
  • 货号：
    CSB-MP848666MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc6a8
  • Uniprot No.：
    Q8VBW1
  • 别名：
    Slc6a8; CrtSodium- and chloride-dependent creatine transporter 1; CT1; Creatine transporter 1; Solute carrier family 6 member 8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.
  • 基因功能参考文献：
    1. Results show that the loss of cerebral Cr is responsible for the learning and memory deficits seen in ubiquitous Slc6a8(-/y) mice. PMID: 29384270
    2. There were no changes in mitochondrial respiration when normalized to mitochondrial number, suggesting that the increase in respiration observed could be to higher mitochondrial content in Crt (-/y) mice PMID: 27401086
    3. Our data suggest that brain Cr depletion causes both early intellectual disability and late progressive cognitive decline, and identify novel targets to design intervention strategies aimed at overcoming brain CCDS1 alterations. PMID: 27466184
    4. Ubiquitous CrT knockout mice have learning and memory deficits resembling human CrT deficiency PMID: 21249153
    5. myocardial creatine transporter has a role in progressive heart failure and decreased glycolytic capacity PMID: 19913546
    6. AMPK inhibits apical membrane CRT/Slc6a8 expression in kidney proximal tubule cells, which could be important in reducing cellular energy expenditure and unnecessary creatine reabsorption under conditions of local and whole body metabolic stress. PMID: 20462973
    7. This induction of creatine transport activity by hypertonicity is not confined to muscle cells: a similar induction was shown in porcine endothelial cells. PMID: 16873409
    8. Thus, the creatine transporter is required for creatine uptake through the plasma membrane of brain neurons. PMID: 16949212
    9. This study reveals the presence of a novel SLC6A8 splice variant, SLC6A8C in human and mouse. PMID: 18515020

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A8 subfamily
  • 数据库链接：

    KEGG: mmu:102857

    STRING: 10090.ENSMUSP00000033752

    UniGene: Mm.274553

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