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  4. Recombinant Mouse Short transient receptor potential channel 4 (Trpc4), partial

Recombinant Mouse Short transient receptor potential channel 4 (Trpc4), partial

  • 中文名称：
    小鼠Trpc4重组蛋白
  • 货号：
    CSB-YP868755MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Trpc4重组蛋白
  • 货号：
    CSB-EP868755MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Trpc4重组蛋白
  • 货号：
    CSB-EP868755MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Trpc4重组蛋白
  • 货号：
    CSB-BP868755MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Trpc4重组蛋白
  • 货号：
    CSB-MP868755MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trpc4
  • Uniprot No.：
    Q9QUQ5
  • 别名：
    Trpc4; Trrp4; Short transient receptor potential channel 4; TrpC4; Capacitative calcium entry channel Trp4; Receptor-activated cation channel TRP4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Trpc4 deficient mice lack a store-operated calcium entry in endothelial cells.
  • 基因功能参考文献：
    1. the antidepressant and anxiolytic-like effects of a newly identified TRPC4/C5 inhibitor, M084. PMID: 26317356
    2. TRPC4 knockdownsuppressed the activation of ERK, p38 MAPK and AKT signalingpathway. PMID: 25605522
    3. Changes in ion selectivity and pore dilation of the TRPC4 channel elicited by the Galphai2 subunit, were studied. PMID: 24011658
    4. Constitutive ablation of TRPC4 in the amygdala is associated with diminished anxiety levels. PMID: 24599464
    5. the S4-S5 linker is a critical constituent of TRPC4/C5 channel gating and that disturbance of its sequence allows channel opening independent of any sensor domain. PMID: 23677990
    6. The results of this study suggested that TRPC4, TRPM4, TRPM8 and TRPV1, showed statistically significant variation in mRNA levels between DRGs from different segments, suggesting ganglion-specific regulation of TRP channel gene expression. PMID: 23410158
    7. Identified four phosphorylation sites in the C-terminus of TRPC4beta. Data show that TRPC4beta in mammalian cells is highly phosphorylated under basal conditions at multiple sites. PMID: 22847694
    8. This study concluded that TRPC4 can be activated downstream of NMDA receptor activation and contribute to slow synaptic transmission in the olfactory bulb, including the calcium dynamics required for asynchronous release from the granule cell spine. PMID: 22539836
    9. TRPV4+/+ macrophages restored susceptibility of TRPV4-/- lungs to mechanical injury. PMID: 20562229
    10. study identified the expression pattern and function of the TRPC4 and 5 channels in the brain PMID: 17593972
    11. TRP4 is necessary for cystic fibrosis transmembrane conductance regulator activation in vascular endothelium. PMID: 11356184
    12. mSTRPC4 therefore probably functions as a heteromultimer PMID: 11815479
    13. can be activated by G-protein-coupled receptors and provides sufficient Ca(2+) to trigger exocytosis in neuroendocrine cells PMID: 11856742
    14. demonstration of presence of in interstitial cells of Cajal PMID: 11897792
    15. TRPC4-alpha may form the homotetrameric store-operated Ca2+ channel in mouse mesangial cells. PMID: 15044151
    16. TRPC1, but not TRPC4, interacts with PLCgamma1 and the inositol 1,4,5-trisphosphate receptor (IP3R). PMID: 15654973
    17. propose that TRPC3 and TRPC4 are subunits of native endothelial cation channels that are governed by the cellular redox state PMID: 16537542
    18. Distribution of TRPC4 in developing and adult murine brain. PMID: 17345099
    19. TRPC channels are involved in generating epileptiform discharges and are associated with a neuronal activity- and PLCbeta1-dependent translocation of TRPC4 from the plasmalemma to the cytoplasmic compartment. PMID: 17402970
    20. To elucidate domains that mediate channel complex formation, dominant negative effects of N- or C-terminal TRPC4/5 fragments on respective currents of full-length proteins, was evaluated. PMID: 17624425
    21. Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in adult mice lacking TR4 orphan nuclear receptor. PMID: 17706948
    22. TRPC4 channels integrate a variety of G-protein-dependent stimuli, including a PIP(2)/cytoskeleton dependence reminiscent of the TRPC4-like muscarinic agonist-activated cation channels in ileal myocytes. PMID: 18230622
    23. responses to diverse external stimuli and convert them into intracellular calcium signals. (review) PMID: 18758036
    24. These results suggest that Galphai is involved specifically in the activation of TRPC4. PMID: 18854172
    25. thrombin-induced p65/RelA, AMPK, and PKCdelta activation were markedly reduced by knockdown of the TRPC isoform TRPC1 expressed in human endothelial cells and in endothelial cells obtained from Trpc4 knock-out mice. PMID: 18990707
    26. These findings indicated that the self-association of two distinct domains in the N-terminus of TRPC4 is involved in the assembly of the tetrameric channel. PMID: 19070363
    27. Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. PMID: 19549525

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC4 sub-subfamily
  • 组织特异性：
    Abundantly expressed in brain (hippocampal CA1 pyramidal neurons, dentate gyrus granule cells, and cerebral cortical neurons, and in the septal nuclei and the mitral layer of olfactory bulb). Lower levels are detected in other tissues.
  • 数据库链接：

    KEGG: mmu:22066

    STRING: 10090.ENSMUSP00000029311

    UniGene: Mm.10100

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