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  4. Recombinant Mouse Serine/threonine-protein kinase LMTK1 (Aatk), partial

Recombinant Mouse Serine/threonine-protein kinase LMTK1 (Aatk), partial

  • 中文名称：
    Recombinant Mouse Serine/threonine-protein kinase LMTK1(Aatk) ,partial
  • 货号：
    CSB-YP768914MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Serine/threonine-protein kinase LMTK1(Aatk) ,partial
  • 货号：
    CSB-EP768914MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Serine/threonine-protein kinase LMTK1(Aatk) ,partial
  • 货号：
    CSB-EP768914MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Serine/threonine-protein kinase LMTK1(Aatk) ,partial
  • 货号：
    CSB-BP768914MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Serine/threonine-protein kinase LMTK1(Aatk) ,partial
  • 货号：
    CSB-MP768914MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Aatk
  • Uniprot No.：
    Q80YE4
  • 别名：
    Aatk; Aatyk; Kiaa0641; Lmr1; Lmtk1; Serine/threonine-protein kinase LMTK1; EC 2.7.11.1; Apoptosis-associated tyrosine kinase; AATYK; Brain apoptosis-associated tyrosine kinase; Lemur tyrosine kinase 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in neuronal differentiation.
  • 基因功能参考文献：
    1. The results showed that AATYK knockdown inhibited Oligodendrocytes differentiation and the expression of myelin genes in vitro. PMID: 29556912
    2. LMTK1 negatively controls dendritic formation by regulating Rab11A-positive endosomal trafficking. PMID: 24672056
    3. Overexpression of the unphosphorylated mutant LMTK1-S34A dramatically promotes axonal outgrowth in cultured neurons. PMID: 22573681
    4. results suggest a possibility that AATYK1A plays a role in early to recycling endosomes and its function is regulated by phosphorylation with Cdk5 or Src-family kinases PMID: 20422042
    5. Expression of AATYK mRNA and protein increased during postnatal brain development. In immature granule cells, overexpression of AATYK promoted neurite outgrowth; a tyrosine kinase-defective mutant significantly inhibited it. PMID: 12670708
    6. phosphorylation states of AATYK are closely related to the high potassium-induced survival and low potassium-induced apoptosis of cerebellar granule cells PMID: 16100393
    7. AATYK1 indirectly inhibits the SPAK/WNK4 activation of the Na-K-2Cl cotransporter by scaffolding an inhibitory phosphatase in proximity to a stimulatory kinase. PMID: 17267545

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, dendrite. Cell projection, axon. Cell projection, growth cone.; [Isoform 2]: Membrane. Note=Peripheral membrane protein.; [Isoform 3]: Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family
  • 组织特异性：
    Expressed in brain, and, to a lower extent, in kidney, heart, lung and skeletal muscle. In the brain, expressed in the olfactory bulb, cerebellum, striatum, hippocampal formation, thalamus, hypothalamus, and pontine nuclei (at protein level).
  • 数据库链接：

    KEGG: mmu:11302

    STRING: 10090.ENSMUSP00000067181

    UniGene: Mm.6826

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