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  4. Recombinant Mouse Seizure protein 6 (Sez6), partial

Recombinant Mouse Seizure protein 6 (Sez6), partial

  • 中文名称：
    小鼠Sez6重组蛋白
  • 货号：
    CSB-YP745885MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sez6重组蛋白
  • 货号：
    CSB-EP745885MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sez6重组蛋白
  • 货号：
    CSB-EP745885MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sez6重组蛋白
  • 货号：
    CSB-BP745885MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sez6重组蛋白
  • 货号：
    CSB-MP745885MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sez6
  • Uniprot No.：
    Q7TSK2
  • 别名：
    Sez6; Kiaa4158; Seizure protein 6; SEZ-6; Brain-specific receptor-like protein C; BSRP-C
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity.
  • 基因功能参考文献：
    1. study demonstrates that SEZ6 and SEZ6L are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF are suitable markers to monitor BACE1 inhibition in mice PMID: 27716410
    2. results indicate that N-glycosylation regulates cell morphology through modulating the cell surface distribution of sez-6 protein PMID: 25960298
    3. co-expression of sez-6 with motopsin restored the effect of motopsin at the basal level, while sez-6 expression alone showed no effects on cell morphology. Our results suggest that the interaction of motopsin and sez-6 modulates neuronal cell morphology PMID: 23770366
    4. Spatiotemporal alterations of the regional and intracellular distribution of Sez-6 suggest its multiple functions during the postnatal development of the forebrain. PMID: 21334315
    5. Retinal morphology, ganglion cell dendritic branching and ERG waveforms appeared normal in the Sez-6 knockout mouse suggesting that, in spite of widespread expression of Sez-6, retinal function in the absence of Sez-6 is not affected PMID: 19662096
    6. the pattern of SEZ-6 expression is closely tied with the emergence of the neocortical layers and hippocampus, and implies a forebrain-specific role for this gene during development PMID: 12351182
    7. In conclusion, cell-surface protein complexes involving Sez-6 help to sculpt the dendritic arbor, in turn enhancing synaptic connectivity. PMID: 18031681

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Note=Localized on dendrites and in the postsynaptic fraction. Does not appear to be enriched at synapses, at least not in the presynaptic axon terminal.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, dendrite. Note=Localized on dendrites and in the synaptic and postsynaptic fraction.; [Isoform 3]: Secreted. Cytoplasm.
  • 蛋白家族：
    SEZ6 family
  • 组织特异性：
    Brain-specific. Expressed in extrasynaptic and synaptic subcellular fractions (at protein level). Expression correlates with the most active periods of cortical neurogenesis and neuronal maturation. Expression is restricted to the gray matter with higher
  • 数据库链接：

    KEGG: mmu:20370

    STRING: 10090.ENSMUSP00000091532

    UniGene: Mm.229330

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