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  4. Recombinant Mouse SUN domain-containing protein 1 (Sun1), partial

Recombinant Mouse SUN domain-containing protein 1 (Sun1), partial

  • 中文名称：
    小鼠Sun1重组蛋白
  • 货号：
    CSB-YP866692MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sun1重组蛋白
  • 货号：
    CSB-EP866692MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sun1重组蛋白
  • 货号：
    CSB-EP866692MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sun1重组蛋白
  • 货号：
    CSB-BP866692MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sun1重组蛋白
  • 货号：
    CSB-MP866692MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sun1
  • Uniprot No.：
    Q9D666
  • 别名：
    Sun1; Unc84a; SUN domain-containing protein 1; Protein unc-84 homolog A; Sad1/unc-84 protein-like 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links.; Isoform 5 may be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN1 isoform 5:SYNE3 LINC complex may tether spermatid nuclei to anterior cytoskeletal structures such as actin filaments present at membraneous junctions of spermatids and Sertoli cells.
  • 基因功能参考文献：
    1. Results provide evidence that SUN1 and KASH5 are essential factors in the regulation of meiotic resumption and spindle formation. PMID: 26842404
    2. A cell-type-specific role for Sun1 and Sun2 in nucleokinesis during cerebellar development, is reported. PMID: 26035387
    3. ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome. PMID: 25380821
    4. our results clearly indicate that SUN1 and SUN2, at least partially, fulfill redundant meiotic functions PMID: 24586178
    5. Sun1, a component of LINC complexes, but not A-type lamins, which interact with LINC complexes at the nuclear envelope, participate in cone nuclei positioning. PMID: 23071752
    6. Sun1 has a role in DNA damage response. PMID: 22863315
    7. It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin complex. PMID: 22826121
    8. These findings implicate Sun1 protein accumulation as a common pathogenic event in Lmna(-/-), LmnaDelta9 mice, models for Emery-Dreifuss muscular dystrophy and Hutchinson-Gilford progeria disorders. PMID: 22541428
    9. Syne-2, SUN1 and SUN2 play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development. PMID: 21177258
    10. Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development PMID: 20108321
    11. perturbations in lamin A-SUN1 and SUN2 protein interactions may underlie the opposing effects of EDMD and HGPS mutations on nuclear and cellular mechanics PMID: 19933576
    12. The Sun1 serves as a 'structural bridge' connecting the nuclear interior with the actin cytoskeleton. PMID: 16079285
    13. SUN1 interacts with nuclear lamin A and cytoplasmic nesprins (nesprin-1 and nesprin-2)to provide a physical connection between the nuclar lamina and the cytoskeleton. PMID: 16648470
    14. SUN1 and SUN2 may form a physical interaction between the nuclear envelope and the centrosome PMID: 17132086
    15. Sun1-/- P14 testes are repressed for the expression of reproductive genes and have no detectable piRNA PMID: 19211677
    16. These results clearly indicate that SUN1 and SUN2 function critically in skeletal muscle cells for Syne-1 localization at the nuclear envelope, which is essential for proper myonuclear positioning. PMID: 19509342
    17. The study indicated that the SUN1-KASH complexes mediate the coupling between the nucleus and the centrosome and provide anchors in the nuclear envelope for cytoplasmic dynein/dynactin during neuronal migration. PMID: 19874786

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  • 亚细胞定位：
    Nucleus inner membrane; Single-pass type II membrane protein.; [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane.
  • 组织特异性：
    Widely expressed. Expressed in cochlear outer hair cells (at protein level). Seven isoforms are expressed in testis including testis-specific isoform 5. Isoform 5 is the only isoform expressed at the end of sperm differentiation. Six isoforms are expresse
  • 数据库链接：

    KEGG: mmu:77053

    STRING: 10090.ENSMUSP00000056655

    UniGene: Mm.210845

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