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  4. Recombinant Mouse Retinol-binding protein 3 (Rbp3), partial

Recombinant Mouse Retinol-binding protein 3 (Rbp3), partial

  • 中文名称：
    小鼠Rbp3重组蛋白
  • 货号：
    CSB-YP019482MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rbp3重组蛋白
  • 货号：
    CSB-EP019482MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rbp3重组蛋白
  • 货号：
    CSB-EP019482MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rbp3重组蛋白
  • 货号：
    CSB-BP019482MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rbp3重组蛋白
  • 货号：
    CSB-MP019482MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rbp3
  • Uniprot No.：
    P49194
  • 别名：
    Rbp3; Retinol-binding protein 3; Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
  • 基因功能参考文献：
    1. The 629-643 RBP-3 peptide is a major uveitogenic peptide for the induction of autoimmune uveoretinitis in C57BL/6J mice and the persistent clinical disease induced with one peptide leads to epitope spreading. PMID: 26152845
    2. We propose that down-regulation of IRBP may represent an early and novel pathogenic mechanism in degenerative retinal diseases PMID: 25692504
    3. Although death signaling proteins are increased, the caspase-dependent and independent apoptotic pathways are mildly activated in Irbp-deficient retinas. PMID: 24174679
    4. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). PMID: 23486466
    5. In addition to its role in the visual cycle, IRBP is needed for normal eye development. PMID: 21642628
    6. IRBP is essential to normal cone function and demonstrate that differences exist in the visual cycle of rods and cones. PMID: 20238012
    7. these findings suggest that IRBP plays an important role in the delivery of 11-cis-retinol to cones and can facilitate cone function in the presence of light PMID: 21430170
    8. analysis of the structure and sequence of the IRBP gene PMID: 12434304
    9. data show that presence of IRBP is necessary in ocular and pineal gland tissues for expression of autoimmune uveitis PMID: 14599843
    10. Expression of IRBP within the thymus is critical to prevent spontaneous autoimmunity against the eye, even in the presence of autoimmune regulator aire. PMID: 17116738
    11. Data indicate that IRBP is essential to normal cone function and demonstrate that IRBP has a cone-specific visual cycle function. PMID: 19357286
    12. Activation of IRBP-specific T cells from mice immunized with uveitogenic IRBP(1-20) peptide under T-helper cell interleukin (IL)17-polarizing conditions is associated with increased expansion of T cells expressing the gamma delta T cell receptor. PMID: 19542467

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
  • 蛋白家族：
    Peptidase S41A family
  • 组织特异性：
    Expressed in the photosensitive tissues; retina and pineal gland.
  • 数据库链接：

    KEGG: mmu:19661

    STRING: 10090.ENSMUSP00000040249

    UniGene: Mm.436622

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