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  4. Recombinant Mouse Retinoblastoma-like protein 2 (Rbl2), partial

Recombinant Mouse Retinoblastoma-like protein 2 (Rbl2), partial

  • 中文名称：
    小鼠Rbl2重组蛋白
  • 货号：
    CSB-YP734133MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rbl2重组蛋白
  • 货号：
    CSB-EP734133MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rbl2重组蛋白
  • 货号：
    CSB-EP734133MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rbl2重组蛋白
  • 货号：
    CSB-BP734133MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rbl2重组蛋白
  • 货号：
    CSB-MP734133MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rbl2
  • Uniprot No.：
    Q64700
  • 别名：
    Rbl2; Retinoblastoma-like protein 2; 130 kDa retinoblastoma-associated protein; p130; Retinoblastoma-related protein 2; RBR-2; pRb2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
  • 基因功能参考文献：
    1. Loss of Rb 130 gene is associated with retinoblastoma. PMID: 27750399
    2. In skeletal dysplasias cell cycle progression is compromised in the G1 phase due to reduced phosphorylation of the pocket protein p130 leading to inhibition of transcription factors of the E2F family. PMID: 24820054
    3. Following stress exposure, E2F4-p130 complexes are lost rapidly along with the presence of E2F4 at E2F-containing B-Myb promoter sites. PMID: 24828495
    4. The balance between phosphorylation and acetylation of Rb2/p130 is essential for its biological function in cell cycle control. PMID: 23029429
    5. Rb2 coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF) and BORIS in T-antigen-positive but not in T-antigen-negative cells. PMID: 22544282
    6. Wnt/beta-catenin and pRb signal pathways interact with each other and form common p130/Gsk3beta/beta-catenin complex during MSC cycle progression. PMID: 21631154
    7. Gsk3beta, p130 and beta-catenin form in MSC a complex the functional role of which may be associated with activation of differentiation not coupled to cell cycle arrest. PMID: 21516817
    8. the control of vascular injury response is not a redundant feature of pRb proteins but primarily specific for p130 PMID: 12860570
    9. tyrosine phosphorylation sites in CAS have a role in promoting cell migration PMID: 15247284
    10. The Rbl2 protein has a role in directing full heterochromatin formation. PMID: 15750587
    11. Rb2 and kip1 have roles in controlling mobilization of angiogenic progenitors from the bone marrow PMID: 15867156
    12. p130 is a bona fide cyclin-dependent kinase inhibitor and cooperates with p27Kip1 to regulate hematopoietic cell proliferation in vivo. PMID: 16880527
    13. This study investigated if the distribution between nucleus and cytoplasm of the transcription factors E2F4 and E2F5 is mediated by pRb2/p130 and if the presence of JCV T-antigen may impair this shuttling by sequestering pRb2/p130. PMID: 17385710
    14. miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. PMID: 18287052
    15. These results identify a pathway by which miR-290 directly regulates Rbl2-dependent Dnmt expression, indirectly affecting telomere-length homeostasis. PMID: 18311151
    16. Overexpression of E2F5/p130 in post-mitotic lens fiber cells does not affect normal differentiation, but can inhibit inappropriate cell cycle reentry induced by activator E2Fs. P130 is key player in inhibitory process PMID: 18385796
    17. along with p107, and Rb maintains hematopoietic stem cells quiescence and the balance between lymphoid and myeloid cell lineages PMID: 18940733
    18. these studies identify a novel proapototic function for p130 PMID: 19887614

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Retinoblastoma protein (RB) family
  • 数据库链接：

    KEGG: mmu:19651

    STRING: 10090.ENSMUSP00000034091

    UniGene: Mm.235580

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