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  4. Recombinant Mouse Retinoblastoma-like protein 1 (Rbl1), partial

Recombinant Mouse Retinoblastoma-like protein 1 (Rbl1), partial

  • 中文名称：
    小鼠Rbl1重组蛋白
  • 货号：
    CSB-YP717574MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rbl1重组蛋白
  • 货号：
    CSB-EP717574MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rbl1重组蛋白
  • 货号：
    CSB-EP717574MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rbl1重组蛋白
  • 货号：
    CSB-BP717574MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rbl1重组蛋白
  • 货号：
    CSB-MP717574MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rbl1
  • Uniprot No.：
    Q64701
  • 别名：
    Rbl1; Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor.
  • 基因功能参考文献：
    1. the transcriptional corepressor p107 orchestrates a metabolic checkpoint that determines adipocyte lineage fates for non-committed progenitors. PMID: 28233396
    2. p107 is required for the efficient recruitment of an activating SWI/SNF chromatin-remodeling complex, an essential event in Alpl induction. PMID: 25182511
    3. while p107 alone did not have an essential role in islet homeostasis, when combined with Rb deletion, its absence potentiated apoptosis of both alpha and beta cells resulting in glucose intolerance and diminished islet mass with ageing PMID: 25249236
    4. Findings indicate that retinoblastoma-like protein p107 expression in stem cells commits cells to the white versus brown adipose lineage. PMID: 24449206
    5. p107 retinoblastoma protein is regulated by Cdk6/Ccnd1 in growth plates. PMID: 23803733
    6. Cell cycle assays further indicated that activation of p107 transcription during S phase through the two E2F binding sites was critical for controlled cell cycle progression. PMID: 20585628
    7. p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development PMID: 12086466
    8. p107 and p130, but not pRb, are critical effectors of FGF-mediated growth inhibition in chondrocytes. PMID: 12177046
    9. regulation of p107 and p130 expression during adipocyte differentiation with/without inhibition of MEK PMID: 12242027
    10. impaired terminal differentiation in the interfollicular keratinocytes of p107/p130-double-null mice epidermis PMID: 12702649
    11. the pRb family member p107 is not a key regulator in vascular injury response. PMID: 12860570
    12. Autorepression of c-myc requires initiator, E2F-binding site elements and p107. PMID: 14716294
    13. p107 binds to cyclin A47 when p21 and p27 are absent. PMID: 15070741
    14. p107 regulates neural precursor cells in the mouse brain. PMID: 15353549
    15. in a variety of tissues tumor development by loss of pRB is suppressed by its homologs p107 and p130 PMID: 15574596
    16. Data suggest that p107, in addition to its interaction with E2F, inhibits cell proliferation through the control of Skp2 expression and the resulting stabilization of p27. PMID: 15631990
    17. The Rbl1 protein shows a marked genomic instability, which is coincidental with decreased DNA methylation, increased acetylation of histone H3 and decreased tri-methylation of histone H4 at lysine 20 (H4K20). PMID: 15750587
    18. loss of pRb and p107 or p130 together produced chronic hyperplasia and dysplasia of the small intestinal and colonic epithelium PMID: 16258171
    19. These results demonstrate that p27 carries out overlapping functions with p107 in controlling cell cycle exit during chondrocyte maturation. PMID: 17502351
    20. p107 regulates the rate of progenitor commitment to a neuronal fate. PMID: 17591923
    21. data demonstrate that p107 behaves as a tumor suppressor in epidermis in the absence of pRb and suggest novel tumor-suppressive roles for p107 in the context of functional p53 and activated Ras PMID: 17932945
    22. along with Rb, and p130 maintains hematopoietic stem cells quiescence and the balance between lymphoid and myeloid cell lineages PMID: 18940733
    23. These results support a model whereby p107/E2F3 regulates the pool of FGF-responsive progenitors by directly regulating FGF2 gene expression in vivo. PMID: 19564414

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Retinoblastoma protein (RB) family
  • 组织特异性：
    Highly expressed in fetal heart and liver. Expressed at low levels in all other fetal tissues except skeletal muscle. High levels in neonatal spleen and thymus with low levels in other tissues. In adult, highly expressed in testis. Barely detectable in ot
  • 数据库链接：

    KEGG: mmu:19650

    STRING: 10090.ENSMUSP00000029170

    UniGene: Mm.244671

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