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  4. Recombinant Mouse Repulsive guidance molecule A (Rgma)

Recombinant Mouse Repulsive guidance molecule A (Rgma)

  • 中文名称：
    小鼠Rgma重组蛋白
  • 货号：
    CSB-YP754243MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rgma重组蛋白
  • 货号：
    CSB-EP754243MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rgma重组蛋白
  • 货号：
    CSB-EP754243MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rgma重组蛋白
  • 货号：
    CSB-BP754243MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rgma重组蛋白
  • 货号：
    CSB-MP754243MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rgma
  • Uniprot No.：
    Q6PCX7
  • 别名：
    Rgma; Repulsive guidance molecule A; RGM domain family member A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    170-427
  • 氨基酸序列
    P HLRTFTDHFQ TCKVQGAWPL IDNNYLNVQV TNTPVLPGSA ATATSKLTII FKNFQECVDQ KVYQAEMDEL PSAFADGSKN GGDKHGANSL KITEKVSGQH VEIQAKYIGT TIVVRQVGRY LTFAVRMPEE VVNAVEDRDS QGLYLCLRGC PLNQQIDFQA FRANAESPRR PAAASPSPVV PETFPYETAV AKCKEKLPVE DLYYQACVFD LLTTGDVNFT LAAYYALEDG KMLHSNKDKL HLFERTRELP GAVAAAA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
  • 基因功能参考文献：
    1. promotes dendritic cell maturation PMID: 26896667
    2. RGMa is involved in Th17-cell-mediated neurodegeneration. PMID: 25456136
    3. repulsive RGMa-Neogenin interactions drive interneurons into the migratory corridor PMID: 24312340
    4. Postnatal spiral ganglion neurons retain capacity to send out processes that respond to signals for synaptogenesis, but postnatal RGMa expression appears to be detrimental to regeneration of afferent hair cell innervation and antagonizes synaptogenesis PMID: 24123853
    5. RGMa inhibits axon growth by phosphorylating CRMP-2 via both Rho-kinase and GSK-3beta signaling pathways. PMID: 23275173
    6. RGMa enhances CD4+ T cell activation facilitating central nervous system intervention in an animal model of multiple sclerosis presented in this review. PMID: 22183806
    7. Loss-of-function analysis in mice revealed that RGMa may play a more important role in neural tube morphogenesis. PMID: 22568948
    8. identification of neogenin-binding site on the repulsive guidance molecule A PMID: 22396795
    9. activated microglia play a major role in inhibiting axon regeneration via RGMa PMID: 21957482
    10. RGM-A is a unique endogenous inhibitor of leukocyte chemotaxis that limits inflammatory leukocyte traffic PMID: 21467223
    11. Neutralizing antibodies to RGMa attenuated clinical symptoms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and reduced invasion of inflammatory cells into the CNS. PMID: 21423182
    12. Our data indicate an important role of RGMa for the layer-specific termination of the perforant pathway as a repulsive signal that compels entorhinal fibers to stay in their correct target zone PMID: 15084667
    13. a role for RGMa as a bone morphogenic protein co-receptor. PMID: 15975920
    14. RGMa-mediated neogenin signal transduction pathway involved in axonal guidance. PMID: 17389603
    15. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID: 17472960
    16. RGMa may negatively regulate neuronal network formation in cortical neurons. PMID: 18519029

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Repulsive guidance molecule (RGM) family
  • 组织特异性：
    Expressed in gradient in periventricular layers of the developing nervous system. In adult, expressed in scattered cells throughout the brain.
  • 数据库链接：

    KEGG: mmu:244058

    STRING: 10090.ENSMUSP00000091870

    UniGene: Mm.333943

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