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  4. Recombinant Mouse Regulating synaptic membrane exocytosis protein 2 (Rims2), partial

Recombinant Mouse Regulating synaptic membrane exocytosis protein 2 (Rims2), partial

  • 中文名称：
    小鼠Rims2重组蛋白
  • 货号：
    CSB-YP863653MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rims2重组蛋白
  • 货号：
    CSB-EP863653MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rims2重组蛋白
  • 货号：
    CSB-EP863653MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rims2重组蛋白
  • 货号：
    CSB-BP863653MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rims2重组蛋白
  • 货号：
    CSB-MP863653MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rims2
  • Uniprot No.：
    Q9EQZ7
  • 别名：
    Rims2; Rab3ip2; Rim2; Regulating synaptic membrane exocytosis protein 2; Rab-3-interacting molecule 2; RIM 2; Rab-3-interacting protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes.
  • 基因功能参考文献：
    1. RIM2alpha and RIM2beta promote a large complement of synaptic CaV1.3 Ca(2+) channels at inner hair cell presynaptic active zones and are required for normal hearing. PMID: 26034270
    2. Rim2alpha is involved in Zona Pellucida dependent signaling. PMID: 25240052
    3. Rim2alpha determines docking and priming states in insulin granule exocytosis depending on its interacting partner, Rab3A or Munc13-1, respectively. PMID: 20674857
    4. Alternative splicing in the Rab-binding domain of Rim2 regulates Rab3A binding activity. PMID: 15330860
    5. Cyclic AMP rescue of priming defects caused by Munc13-1 deficiency signaling pathways requires downstream Munc13-1-Rim2 interaction. PMID: 17639022

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  • 亚细胞定位：
    Cell junction, synapse, synaptosome.
  • 组织特异性：
    Detected in testis, pituitary and an insulinoma cell line. Detected at low levels in cerebellar cortex.
  • 数据库链接：

    KEGG: mmu:116838

    UniGene: Mm.309296

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