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  4. Recombinant Mouse Receptor-type tyrosine-protein phosphatase delta (Ptprd), partial

Recombinant Mouse Receptor-type tyrosine-protein phosphatase delta (Ptprd), partial

  • 中文名称：
    小鼠Ptprd重组蛋白
  • 货号：
    CSB-YP727073MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ptprd重组蛋白
  • 货号：
    CSB-EP727073MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ptprd重组蛋白
  • 货号：
    CSB-EP727073MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ptprd重组蛋白
  • 货号：
    CSB-BP727073MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ptprd重组蛋白
  • 货号：
    CSB-MP727073MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ptprd
  • Uniprot No.：
    Q64487
  • 别名：
    Ptprd; Receptor-type tyrosine-protein phosphatase delta; Protein-tyrosine phosphatase delta; R-PTP-delta; EC 3.1.3.48
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

问答及客户评论

■ 常见问题解答
Q:

I'd like to know if this product is available. I would also like to confirm that the recombinant protein being expressed is the extracellular domain of PTPRD.

A:
Thanks for your inquiry，The product details is as below.
This protein is the Tyrosine-protein phosphatase 2 Domain of mouse PTPRD.
Recombinant Mouse Receptor-type tyrosine-protein phosphatase delta(Ptprd) ,partial
CSB-YP727073MO >> Yeast
CSB-EP727073MO >> E.coli
CSB-BP727073MO >> Baculovirus
CSB-MP727073MO >> Mammalian cell working days
Expression Region: 1644-1903aa; C-terminal fragment; Tyrosine-protein phosphatase 2 Domain
Tag Info: YP: N-terminal 6xHis-tag; EP, BP, MP: N-terminal 10xHis-tag and C-terminal Myc-tag
Target Protein Sequence:

MELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEY

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靶点详情

  • 功能：
    Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.
  • 基因功能参考文献：
    1. Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPsigma and Modulation of the Rho/ROCK Pathway. PMID: 25703008
    2. Ptprd is a tumor suppressor that can promote tumorigenesis in concert with Cdkn2a loss. PMID: 25138050
    3. We reveal that PTPRD is a bona fide tumor suppressor, pinpoint PTPRD loss as a cause of aberrant STAT3 activation in gliomas, and establish PTPRD loss, in the setting of CDKN2A/p16(INK4A) deletion, as a driver of glioma progression. PMID: 24843164
    4. RPTP-sigma and RPTP-delta complement each other functionally during mammalian development, and reveal an essential contribution of RPTP-sigma and RPTP-delta to appropriate motoneuron axon targeting during mammalian axonogenesis. PMID: 16738228
    5. Receptor protein tyrosine phosphatase-delta cooperates with hedgehog-responsive gene MIM to induce cytoskeletal remodeling. PMID: 15684034
    6. PTPRD may be one of a select group of tumor suppressor genes that are inactivated in a wide range of common tumor types. PMID: 19074898

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 2A subfamily
  • 组织特异性：
    Brain, kidney, heart, and some B-cell lines.
  • 数据库链接：

    KEGG: mmu:19266

    STRING: 10090.ENSMUSP00000133468

    UniGene: Mm.184021

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