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  4. Recombinant Mouse Receptor-type tyrosine-protein phosphatase F (Ptprf), partial

Recombinant Mouse Receptor-type tyrosine-protein phosphatase F (Ptprf), partial

  • 中文名称：
    小鼠Ptprf重组蛋白
  • 货号：
    CSB-YP019053MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ptprf重组蛋白
  • 货号：
    CSB-EP019053MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ptprf重组蛋白
  • 货号：
    CSB-EP019053MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ptprf重组蛋白
  • 货号：
    CSB-BP019053MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ptprf重组蛋白
  • 货号：
    CSB-MP019053MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ptprf
  • Uniprot No.：
    A2A8L5
  • 别名：
    Ptprf; Lar; Receptor-type tyrosine-protein phosphatase F; EC 3.1.3.48; Leukocyte common antigen related; LAR
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.
  • 基因功能参考文献：
    1. loss of LAR activity resulted in reduced activity of CDK1. PMID: 27352860
    2. Study has identified LAR as a regulator of key signaling pathways, including mTOR and JNK, and has significantly expanded the number of proteins regulated downstream of LAR phosphatase activity. PMID: 27074791
    3. This study demonstrates the crucial role of LAR in restricting regrowth of injured CNS axons PMID: 25220840
    4. Ptprs and Ptprf deficiency affects mandibular cell proliferation. PMID: 23863482
    5. Inhibition of LAR attenuates palmitate-induced insulin resistance in myotubes. PMID: 22899729
    6. Deletion of LAR in knock-out mice or blockade of LAR with sequence-selective peptides significantly overcomes neurite growth restrictions of chondroitin sulfate proteoglycan in neuronal cultures. PMID: 21976490
    7. the crystal structures of the first and second immunoglobulin-like domains of the Drosophila type IIa receptor Dlar and its mouse homolog LAR were reported. PMID: 21402080
    8. LAR reduces the basal c-Abl activity thereby allowing for platelet derived growth factor beta receptor kinase activation PMID: 21300149
    9. LAR deficiency affected the differentiation & expansion of immature thymocytes, positive & negative selection, & a lower Ca2+ response. LAR is an important modulator of TCR signaling that controls thymocyte differentiation. PMID: 20186877
    10. LAR PTPase domains play distinct functional roles in phosphorylation and dephosphorylation PMID: 12496362
    11. PTP alpha is required for integrin-proximal events and phosphorylates FAK PMID: 12515828
    12. In conclusion, behavioural testing of the LAR tyrosine phosphatase-deficient mice revealed a spatial learning impairment and a significant increase in activity. PMID: 15302123
    13. LAR enhances retinal ganglion cell neurite initiation whilst suppressing retinal ganglion cell survival PMID: 15932596
    14. Results introduce leukocyte common antigen-related (LAR) protein tyrosine phosphatase (PTP) as the first PTP found to be expressed in dentate progenitors and point to inhibition of LAR as a potential strategy for promoting neurogenesis. PMID: 16488625
    15. Here, we report rapid and efficient construction of PTPRF and NWC TgVs without using restriction endonucleases. PMID: 17498650

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  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 2A subfamily
  • 组织特异性：
    Expressed in the cell of the T lineage but not in cells of any other hemopoietic lineage.
  • 数据库链接：

    KEGG: mmu:19268

    STRING: 10090.ENSMUSP00000039368

    UniGene: Mm.29855

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