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  4. Recombinant Mouse Ras-related protein Rab-32 (Rab32)

Recombinant Mouse Ras-related protein Rab-32 (Rab32)

  • 中文名称：
    小鼠Rab32重组蛋白
  • 货号：
    CSB-YP871935MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rab32重组蛋白
  • 货号：
    CSB-EP871935MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rab32重组蛋白
  • 货号：
    CSB-EP871935MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rab32重组蛋白
  • 货号：
    CSB-BP871935MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rab32重组蛋白
  • 货号：
    CSB-MP871935MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rab32
  • Uniprot No.：
    Q9CZE3
  • 别名：
    Rab32; Ras-related protein Rab-32
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-223
  • 氨基酸序列
    AGEGLGQQG ASATAAPETR EHLFKVLVIG ELGVGKTSII KRYVHQLFSQ HYRATIGVDF ALKVLNWDSR TLVRLQLWDI AGQERFGNMT RVYYKEALGA FVVFDISRSS TFDAVLKWKN DLDSKVHLPN GSPIPAVLLA NKCDQKKDNS QSPSQMDQFC KDHGFTGWFE TSAKDNINID EATRFLVENM LANQQSFPSE EIDLDRIKLV EEPPTTKPRS QCC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
  • 基因功能参考文献：
    1. Rab32 represents a general cell-autonomous, antimicrobial defense that is counteracted by two Salmonella effectors. PMID: 26867180
    2. Rab32 could improve the induction of iPSCs through the enhancement of lipid biosynthesis, highlighting the importance of lipid metabolism during reprogramming. PMID: 26559473
    3. antimicrobial functions in macromolecular complex results in bacterial containment PMID: 26885862
    4. Data suggest RUTBC1/SGSM2 in melanocytes functions as physiological GTPase-activating protein for Rab32/Rab38 in regulation of transport of melanogenic enzymes (tyrosinase, tyrosinase-related protein 1, dopachrome isomerase) into melanosomes. PMID: 26620560
    5. RNA interference-mediated depletion of Rab32 or of an essential component of a BLOC complex was sufficient to allow S. Typhi to survive within mouse macrophages. PMID: 23162001
    6. Through a combination of its functions as a PKA-anchoring protein and a regulator of MAM properties, the activity and expression level of Rab32 determine the speed of apoptosis onset. PMID: 20670942
    7. Data report the cloning and characterization of the mouse homologue of human Rab32. PMID: 14499590
    8. Varp functions as the Rab32/38 effector that controls trafficking of Tyrp1 in melanocytes. PMID: 19403694

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  • 亚细胞定位：
    Mitochondrion. Mitochondrion outer membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Melanosome membrane.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 组织特异性：
    Widely expressed with highest levels in liver. Strong expression also found in melanocyte, platelet, mast cell and fibroblast cell lines.
  • 数据库链接：

    KEGG: mmu:67844

    STRING: 10090.ENSMUSP00000019974

    UniGene: Mm.31486

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